Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387315801> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4387315801 endingPage "193" @default.
- W4387315801 startingPage "186" @default.
- W4387315801 abstract "Purpose: Breast cancer accounts for most cancer-related deaths in women with over 2.3 million new breast cancer cases diagnosed every year worldwide. Pim kinases are oncogenic proteins that play important role in various cancers. Pim-1 contains 1.7 kb promoter region without any transcriptional regulation, which is a characteristic feature of a housekeeping or constitutive promoter. This study was carried out to ascertain potential mutations in the promoter region of Pim-1 in breast cancer and also to comprehend the effect of mutations on c-Myc expression as well as on patients’ survival. Methods: Ninety-six Indian subjects with a first diagnosis of breast cancer who underwent surgery at our hospital were recruited in this study. Genomic DNA was isolated from whole blood, amplified and sequenced to identify potential mutations at the promoter region of Pim-1. FFPE sections were used to determine the c-Mycexpression in all the studied groups. Results: We observed a transversion (C>A at –502) and a deletion (–754Cdel) mutation in the promoter region with negligible association with tumor biology and c-Myc expression. Positive c-Myc expression was noted in almost 50% of the studied population with absolute nuclear staining or both cytoplasmic/nuclear staining. As per survival analysis, promoter region mutations did not modulate the patients’ survival, but patients with negative c-Myc expression had better disease-free survival compared with positive c-Myc expression. Conclusion: Our findings identified the presence of mutation in the promoter region of Pim-1 with negligible impact on c-Myc expression in patients with breast cancer." @default.
- W4387315801 created "2023-10-04" @default.
- W4387315801 creator A5004789049 @default.
- W4387315801 creator A5025000953 @default.
- W4387315801 creator A5075806408 @default.
- W4387315801 creator A5085462204 @default.
- W4387315801 creator A5092996669 @default.
- W4387315801 creator A5092996670 @default.
- W4387315801 creator A5092996671 @default.
- W4387315801 creator A5092996672 @default.
- W4387315801 date "2023-07-01" @default.
- W4387315801 modified "2023-10-05" @default.
- W4387315801 title "Impact of promoter region mutations of Pim-1 on c-Myc expression as well as survival in patients with breast cancer" @default.
- W4387315801 doi "https://doi.org/10.17727/jmsr.2023/11-35" @default.
- W4387315801 hasPublicationYear "2023" @default.
- W4387315801 type Work @default.
- W4387315801 citedByCount "0" @default.
- W4387315801 crossrefType "journal-article" @default.
- W4387315801 hasAuthorship W4387315801A5004789049 @default.
- W4387315801 hasAuthorship W4387315801A5025000953 @default.
- W4387315801 hasAuthorship W4387315801A5075806408 @default.
- W4387315801 hasAuthorship W4387315801A5085462204 @default.
- W4387315801 hasAuthorship W4387315801A5092996669 @default.
- W4387315801 hasAuthorship W4387315801A5092996670 @default.
- W4387315801 hasAuthorship W4387315801A5092996671 @default.
- W4387315801 hasAuthorship W4387315801A5092996672 @default.
- W4387315801 hasBestOaLocation W43873158011 @default.
- W4387315801 hasConcept C101762097 @default.
- W4387315801 hasConcept C104317684 @default.
- W4387315801 hasConcept C121608353 @default.
- W4387315801 hasConcept C150194340 @default.
- W4387315801 hasConcept C153911025 @default.
- W4387315801 hasConcept C2908647359 @default.
- W4387315801 hasConcept C501734568 @default.
- W4387315801 hasConcept C502942594 @default.
- W4387315801 hasConcept C530470458 @default.
- W4387315801 hasConcept C54355233 @default.
- W4387315801 hasConcept C71924100 @default.
- W4387315801 hasConcept C86803240 @default.
- W4387315801 hasConcept C99454951 @default.
- W4387315801 hasConceptScore W4387315801C101762097 @default.
- W4387315801 hasConceptScore W4387315801C104317684 @default.
- W4387315801 hasConceptScore W4387315801C121608353 @default.
- W4387315801 hasConceptScore W4387315801C150194340 @default.
- W4387315801 hasConceptScore W4387315801C153911025 @default.
- W4387315801 hasConceptScore W4387315801C2908647359 @default.
- W4387315801 hasConceptScore W4387315801C501734568 @default.
- W4387315801 hasConceptScore W4387315801C502942594 @default.
- W4387315801 hasConceptScore W4387315801C530470458 @default.
- W4387315801 hasConceptScore W4387315801C54355233 @default.
- W4387315801 hasConceptScore W4387315801C71924100 @default.
- W4387315801 hasConceptScore W4387315801C86803240 @default.
- W4387315801 hasConceptScore W4387315801C99454951 @default.
- W4387315801 hasIssue "3" @default.
- W4387315801 hasLocation W43873158011 @default.
- W4387315801 hasOpenAccess W4387315801 @default.
- W4387315801 hasPrimaryLocation W43873158011 @default.
- W4387315801 hasRelatedWork W1975811142 @default.
- W4387315801 hasRelatedWork W2009966535 @default.
- W4387315801 hasRelatedWork W2019988726 @default.
- W4387315801 hasRelatedWork W2082530227 @default.
- W4387315801 hasRelatedWork W2088062465 @default.
- W4387315801 hasRelatedWork W2088063203 @default.
- W4387315801 hasRelatedWork W2111182449 @default.
- W4387315801 hasRelatedWork W2121924440 @default.
- W4387315801 hasRelatedWork W2171277769 @default.
- W4387315801 hasRelatedWork W3196332669 @default.
- W4387315801 hasVolume "11" @default.
- W4387315801 isParatext "false" @default.
- W4387315801 isRetracted "false" @default.
- W4387315801 workType "article" @default.