FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387324463> ?p ?o ?g. }

• W4387324463 abstract "The glmS riboswitch is a motif found in 5′-untranslated regions of bacterial mRNA that controls the synthesis of glucosamine-6-phosphate (GlcN6P), an essential building block for the bacterial cell wall, by a feedback mechanism. Activation of the glmS riboswitch by GlcN6P mimics interferes with the ability of bacteria to synthesize its cell wall. Accordingly, GlcN6P mimics acting as glmS activators are promising candidates for future antibiotic drugs that may overcome emerging bacterial resistance against established antibiotics. We describe the synthesis of a series of phosphonate mimics of GlcN6P as well as the thiasugar analogue of GlcN6P. The phosphonate mimics differ in their pKa value to answer the question of whether derivatives with a pKa matching that of GlcN6P would be efficient glmS activators. We found that all derivatives activate the riboswitch, however, less efficiently than GlcN6P. This observation can be explained by the missing hydrogen bonds in the case of phosphonates and is valuable information for the design of future GlcN6P mimics. The thiasugar analogue of GlcN6P on the other hand turned out to be a glmS riboswitch activator with the same activity as the natural metabolite GlcN6P. The nonphosphorylated thiasugar displayed antimicrobial activity against certain bacilli. Therefore, the compound is a promising lead structure for the development of future antibiotics with a potentially novel mode of action." @default.
• W4387324463 created "2023-10-04" @default.
• W4387324463 creator A5041783466 @default.
• W4387324463 creator A5058487133 @default.
• W4387324463 creator A5059520134 @default.
• W4387324463 creator A5077253315 @default.
• W4387324463 creator A5092533948 @default.
• W4387324463 creator A5092533949 @default.
• W4387324463 creator A5092998588 @default.
• W4387324463 date "2023-10-04" @default.
• W4387324463 modified "2023-10-10" @default.
• W4387324463 title "Phosphonate and Thiasugar Analogues of Glucosamine-6-phosphate: Activation of the <i>glmS</i> Riboswitch and Antibiotic Activity" @default.
• W4387324463 cites W1972708527 @default.
• W4387324463 cites W1974921066 @default.
• W4387324463 cites W1979318173 @default.
• W4387324463 cites W1980545483 @default.
• W4387324463 cites W1987542480 @default.
• W4387324463 cites W1989961446 @default.
• W4387324463 cites W1992582121 @default.
• W4387324463 cites W1998906741 @default.
• W4387324463 cites W1999404678 @default.
• W4387324463 cites W2004201499 @default.
• W4387324463 cites W2007477611 @default.
• W4387324463 cites W2008797142 @default.
• W4387324463 cites W2013781835 @default.
• W4387324463 cites W2022113659 @default.
• W4387324463 cites W2035226890 @default.
• W4387324463 cites W2043057359 @default.
• W4387324463 cites W2049912773 @default.
• W4387324463 cites W2057412751 @default.
• W4387324463 cites W2060029188 @default.
• W4387324463 cites W2067258168 @default.
• W4387324463 cites W2079632539 @default.
• W4387324463 cites W2102192148 @default.
• W4387324463 cites W2104610661 @default.
• W4387324463 cites W2111769513 @default.
• W4387324463 cites W2122282339 @default.
• W4387324463 cites W2124594883 @default.
• W4387324463 cites W2155326939 @default.
• W4387324463 cites W2179395831 @default.
• W4387324463 cites W2323943045 @default.
• W4387324463 cites W2338948298 @default.
• W4387324463 cites W2419203297 @default.
• W4387324463 cites W2562854059 @default.
• W4387324463 cites W2605443933 @default.
• W4387324463 cites W2731961144 @default.
• W4387324463 cites W2764030356 @default.
• W4387324463 cites W2804899379 @default.
• W4387324463 cites W2898867445 @default.
• W4387324463 cites W2901851456 @default.
• W4387324463 cites W2946119588 @default.
• W4387324463 cites W2952564217 @default.
• W4387324463 cites W2971269891 @default.
• W4387324463 cites W3119808766 @default.
• W4387324463 cites W4285744684 @default.
• W4387324463 cites W4301178699 @default.
• W4387324463 cites W4308055892 @default.
• W4387324463 cites W4311928649 @default.
• W4387324463 cites W8574911 @default.
• W4387324463 doi "https://doi.org/10.1021/acschembio.3c00452" @default.
• W4387324463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37793187" @default.
• W4387324463 hasPublicationYear "2023" @default.
• W4387324463 type Work @default.
• W4387324463 citedByCount "0" @default.
• W4387324463 crossrefType "journal-article" @default.
• W4387324463 hasAuthorship W4387324463A5041783466 @default.
• W4387324463 hasAuthorship W4387324463A5058487133 @default.
• W4387324463 hasAuthorship W4387324463A5059520134 @default.
• W4387324463 hasAuthorship W4387324463A5077253315 @default.
• W4387324463 hasAuthorship W4387324463A5092533948 @default.
• W4387324463 hasAuthorship W4387324463A5092533949 @default.
• W4387324463 hasAuthorship W4387324463A5092998588 @default.
• W4387324463 hasBestOaLocation W43873244631 @default.
• W4387324463 hasConcept C104317684 @default.
• W4387324463 hasConcept C148625055 @default.
• W4387324463 hasConcept C185592680 @default.
• W4387324463 hasConcept C194993378 @default.
• W4387324463 hasConcept C2777626080 @default.
• W4387324463 hasConcept C55493867 @default.
• W4387324463 hasConcept C67705224 @default.
• W4387324463 hasConcept C86803240 @default.
• W4387324463 hasConceptScore W4387324463C104317684 @default.
• W4387324463 hasConceptScore W4387324463C148625055 @default.
• W4387324463 hasConceptScore W4387324463C185592680 @default.
• W4387324463 hasConceptScore W4387324463C194993378 @default.
• W4387324463 hasConceptScore W4387324463C2777626080 @default.
• W4387324463 hasConceptScore W4387324463C55493867 @default.
• W4387324463 hasConceptScore W4387324463C67705224 @default.
• W4387324463 hasConceptScore W4387324463C86803240 @default.
• W4387324463 hasFunder F4320320879 @default.
• W4387324463 hasFunder F4320326505 @default.
• W4387324463 hasLocation W43873244631 @default.
• W4387324463 hasLocation W43873244632 @default.
• W4387324463 hasOpenAccess W4387324463 @default.
• W4387324463 hasPrimaryLocation W43873244631 @default.
• W4387324463 hasRelatedWork W1507571087 @default.
• W4387324463 hasRelatedWork W1965704545 @default.
• W4387324463 hasRelatedWork W1974610599 @default.
• W4387324463 hasRelatedWork W2016055422 @default.
• W4387324463 hasRelatedWork W2039954834 @default.

• next