FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387324508> ?p ?o ?g. }

• W4387324508 endingPage "10.1212/WNL.0000000000207876" @default.
• W4387324508 startingPage "10.1212/WNL.0000000000207876" @default.
• W4387324508 abstract "Background and Objectives: The associations of high- and low-density lipoprotein cholesterol (HDL-C and LDL-C) with dementia risk in later life may be complex, and few studies have sufficient data to model non-linearities or adequately adjust for statin use. We evaluated the observational associations of HDL-C and LDL-C with incident dementia in a large and well-characterized cohort with linked survey and electronic health record (EHR) data. Methods: Kaiser Permanente Northern California health plan members aged 55 years and older who completed a health behavior survey between 2002 and 2007, had no history of dementia prior to the survey, and had laboratory measurements of cholesterol within two years after survey completion were followed through December 2020 for incident dementia (Alzheimer’s Disease Related Dementia [ADRD]; Alzheimer’s, vascular, and/or non-specific dementia) based on ICD9 or ICD10 codes in EHRs. We used Cox models for incident dementia with follow-up time beginning 2 years post-survey (after cholesterol measurement) and censoring at end of membership, death, or end of study period. We evaluated non-linearities using b-splines, adjusted for demographic, clinical, and survey confounders, and tested for effect modification by baseline age or prior statin use. Results: 184,367 participants [mean age at survey of 69.5 years, mean HDL-C=53.7 mg/dL (SD = 15.0), LDL-C=108 mg/dL (SD = 30.6)] were included. Higher and lower HDL-C values were associated with elevated ADRD risk compared to the middle quantile: HDL-C in the lowest quintile was associated with an HR of 1.07 (95% CI: 1.03-1.11) and HDL-C in the highest quintile was associated with an HR of 1.15 (95% CI: 1.11-1.20). LDL-C was not associated with dementia risk overall, but statin use qualitatively modified the association. Higher LDL-C was associated with slightly greater risk of ADRD for statin users (53% of the sample, HR per 10 mg/dL increase=1.01, 95% CI: 1.01-1.02) and lower risk for non-users (HR per 10 mg/dL increase=0.98; 95% CI: 0.97-0.99). There was evidence for effect modification by age with linear HDL-C (p=0.003) but not LDL-C (p=0.59). Discussion: Both low and high levels of HDL-C were associated with elevated dementia risk. The association between LDL-C and dementia risk was modest." @default.
• W4387324508 created "2023-10-04" @default.
• W4387324508 creator A5007387022 @default.
• W4387324508 creator A5012170356 @default.
• W4387324508 creator A5014820048 @default.
• W4387324508 creator A5016959999 @default.
• W4387324508 creator A5035611336 @default.
• W4387324508 creator A5037920424 @default.
• W4387324508 creator A5041064351 @default.
• W4387324508 creator A5042472997 @default.
• W4387324508 creator A5044324912 @default.
• W4387324508 creator A5051264184 @default.
• W4387324508 creator A5078021674 @default.
• W4387324508 creator A5085936676 @default.
• W4387324508 creator A5086764903 @default.
• W4387324508 creator A5087266700 @default.
• W4387324508 creator A5091019550 @default.
• W4387324508 date "2023-10-04" @default.
• W4387324508 modified "2023-10-06" @default.
• W4387324508 title "Low- and High-Density Lipoprotein Cholesterol and Dementia Risk Over 17 Years of Follow-up Among Members of a Large Health Care Plan" @default.
• W4387324508 doi "https://doi.org/10.1212/wnl.0000000000207876" @default.
• W4387324508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37793911" @default.
• W4387324508 hasPublicationYear "2023" @default.
• W4387324508 type Work @default.
• W4387324508 citedByCount "0" @default.
• W4387324508 crossrefType "journal-article" @default.
• W4387324508 hasAuthorship W4387324508A5007387022 @default.
• W4387324508 hasAuthorship W4387324508A5012170356 @default.
• W4387324508 hasAuthorship W4387324508A5014820048 @default.
• W4387324508 hasAuthorship W4387324508A5016959999 @default.
• W4387324508 hasAuthorship W4387324508A5035611336 @default.
• W4387324508 hasAuthorship W4387324508A5037920424 @default.
• W4387324508 hasAuthorship W4387324508A5041064351 @default.
• W4387324508 hasAuthorship W4387324508A5042472997 @default.
• W4387324508 hasAuthorship W4387324508A5044324912 @default.
• W4387324508 hasAuthorship W4387324508A5051264184 @default.
• W4387324508 hasAuthorship W4387324508A5078021674 @default.
• W4387324508 hasAuthorship W4387324508A5085936676 @default.
• W4387324508 hasAuthorship W4387324508A5086764903 @default.
• W4387324508 hasAuthorship W4387324508A5087266700 @default.
• W4387324508 hasAuthorship W4387324508A5091019550 @default.
• W4387324508 hasConcept C126322002 @default.
• W4387324508 hasConcept C144024400 @default.
• W4387324508 hasConcept C149923435 @default.
• W4387324508 hasConcept C201903717 @default.
• W4387324508 hasConcept C23131810 @default.
• W4387324508 hasConcept C2777952318 @default.
• W4387324508 hasConcept C2779134260 @default.
• W4387324508 hasConcept C2779483572 @default.
• W4387324508 hasConcept C50382708 @default.
• W4387324508 hasConcept C71924100 @default.
• W4387324508 hasConcept C72563966 @default.
• W4387324508 hasConcept C74909509 @default.
• W4387324508 hasConcept C77350462 @default.
• W4387324508 hasConceptScore W4387324508C126322002 @default.
• W4387324508 hasConceptScore W4387324508C144024400 @default.
• W4387324508 hasConceptScore W4387324508C149923435 @default.
• W4387324508 hasConceptScore W4387324508C201903717 @default.
• W4387324508 hasConceptScore W4387324508C23131810 @default.
• W4387324508 hasConceptScore W4387324508C2777952318 @default.
• W4387324508 hasConceptScore W4387324508C2779134260 @default.
• W4387324508 hasConceptScore W4387324508C2779483572 @default.
• W4387324508 hasConceptScore W4387324508C50382708 @default.
• W4387324508 hasConceptScore W4387324508C71924100 @default.
• W4387324508 hasConceptScore W4387324508C72563966 @default.
• W4387324508 hasConceptScore W4387324508C74909509 @default.
• W4387324508 hasConceptScore W4387324508C77350462 @default.
• W4387324508 hasLocation W43873245081 @default.
• W4387324508 hasLocation W43873245082 @default.
• W4387324508 hasOpenAccess W4387324508 @default.
• W4387324508 hasPrimaryLocation W43873245081 @default.
• W4387324508 hasRelatedWork W1964561326 @default.
• W4387324508 hasRelatedWork W1975046232 @default.
• W4387324508 hasRelatedWork W2088765491 @default.
• W4387324508 hasRelatedWork W2166247085 @default.
• W4387324508 hasRelatedWork W2329095872 @default.
• W4387324508 hasRelatedWork W2396000345 @default.
• W4387324508 hasRelatedWork W3216617598 @default.
• W4387324508 hasRelatedWork W4230495490 @default.
• W4387324508 hasRelatedWork W4281606568 @default.
• W4387324508 hasRelatedWork W4287186518 @default.
• W4387324508 isParatext "false" @default.
• W4387324508 isRetracted "false" @default.
• W4387324508 workType "article" @default.