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- W4387325881 abstract "Abstract Over the past few years, therapeutic drug monitoring (TDM) has gained practical significance in antimicrobial precision therapy. Yet two categories of mainstream TDM techniques (chromatographic analysis and immunoassays) that are widely adopted nowadays retain certain inherent limitations. The use of biosensors, an innovative strategy for rapid evaluation of antimicrobial concentrations in biological samples, enables the implementation of point-of-care testing (POCT) and continuous monitoring, which may circumvent the constraints of conventional TDM and provide strong technological support for individualized antimicrobial treatment. This comprehensive review summarizes the investigations that have harnessed biosensors to detect antimicrobial drugs in biological matrices, provides insights into the performance and characteristics of each sensing form, and explores the feasibility of translating them into clinical practice. Furthermore, the future trends and obstacles to achieving POCT and continuous monitoring are discussed. More efforts are necessary to address the four key ‘appropriateness’ challenges to deploy biosensors in clinical practice, paving the way for personalized antimicrobial stewardship." @default.
- W4387325881 created "2023-10-05" @default.
- W4387325881 creator A5002441340 @default.
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- W4387325881 creator A5013604776 @default.
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- W4387325881 creator A5066110295 @default.
- W4387325881 creator A5079975949 @default.
- W4387325881 date "2023-10-04" @default.
- W4387325881 modified "2023-10-15" @default.
- W4387325881 title "A novel strategy for therapeutic drug monitoring: application of biosensors to quantify antimicrobials in biological matrices" @default.
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