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• W4387325897 abstract "Future Medicinal ChemistryAhead of Print EditorialSTING upregulation strategies to potentiate STING immunotherapyWansang Cho, Jung Ho Lee & Seung Bum ParkWansang Cho https://orcid.org/0000-0002-5262-9543Department of Chemistry, Seoul National University, Seoul, 08826, KoreaSearch for more papers by this author, Jung Ho Lee https://orcid.org/0009-0000-6672-6291Department of Biophysics & Chemical Biology, Seoul National University, Seoul, 08826, KoreaSearch for more papers by this author & Seung Bum Park *Author for correspondence: E-mail Address: sbpark@snu.ac.krhttps://orcid.org/0000-0003-1753-1433Department of Chemistry, Seoul National University, Seoul, 08826, KoreaDepartment of Biophysics & Chemical Biology, Seoul National University, Seoul, 08826, KoreaSPARK Biopharma, Inc., 134 Gwanak-ro Gwanak-gu, Seoul, 08791, KoreaSearch for more papers by this authorPublished Online:4 Oct 2023https://doi.org/10.4155/fmc-2023-0227AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: ImmunotherapySTING AgonistsSTINGTargeted Protein UpregulationReferences1. 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Cancer 18(1), 152 (2019).Crossref, Medline, Google Scholar16. Della Corte CM, Sen T, Gay CM et al. STING pathway expression identifies NSCLC with an immune-responsive phenotype. J. Thorac. Oncol. 15(5), 777–791 (2020).Crossref, Medline, Google Scholar17. Li X, Li Y, Zhao Z et al. Immunogenicity of small-cell lung cancer associates with STING pathway activation and is enhanced by ATR and TOP1 inhibition. Cancer Med. 12(4), 4864–4881 (2023).Crossref, Medline, CAS, Google Scholar18. Chon HJ, Kim H, Noh JH et al. STING signaling is a potential immunotherapeutic target in colorectal cancer. J. Cancer 10(20), 4932–4938 (2019).Crossref, Medline, CAS, Google Scholar19. De Queiroz NMGP, Xia T, Konno H, Barber GN. Ovarian cancer cells commonly exhibit defective STING signaling which affects sensitivity to viral oncolysis. Mol. Cancer Res. 17(4), 974–986 (2019).Crossref, Medline, Google Scholar20. Cho W, Won S, Choi Y et al. Targeted protein upregulation of STING for boosting the efficacy of immunotherapy. Angew. Chem. Int. Ed. Engl. 62(18), e202300978 (2023).Crossref, Medline, CAS, Google Scholar21. Li Q, Lin L, Tong Y et al. TRIM29 negatively controls antiviral immune response through targeting STING for degradation. Cell Discov. 4(1), 13 (2018).Crossref, Medline, Google Scholar22. Falahat R, Berglund A, Perez-Villarroel P et al. Epigenetic state determines the in vivo efficacy of STING agonist therapy. Nat. Commun. 14(1), 1573 (2023).Crossref, Medline, CAS, Google Scholar23. Lai J, Fu Y, Tian S et al. Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice. Mol. Ther. 29(5), 1758–1771 (2021).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Ahead of Print STAY CONNECTED Metrics Downloaded 0 times History Received 4 August 2023 Accepted 10 August 2023 Published online 4 October 2023 Information© 2023 Newlands PressKeywordsImmunotherapySTING AgonistsSTINGTargeted Protein UpregulationAuthor contributionsW Cho prepared the manuscript. W Cho and JH Lee prepared the overall organization of the article and collected data and literature. SB Park oversaw all aspects of the manuscript preparation. All authors critically reviewed the manuscript.Financial & competing interests disclosureThis work was supported by the National Creative Research Initiative Grant (2014R1A3A2030423) through the National Research Foundation of Korea (NRF), funded by the Korean government (Ministry of Science and ICT). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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• W4387325897 title "STING upregulation strategies to potentiate STING immunotherapy" @default.
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