Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387326466> ?p ?o ?g. }
- W4387326466 abstract "The communication between the intestinal epithelium and the enteric nervous system has been considered indirect. Mechanical or chemical stimuli activate enteroendocrine cells inducing hormone secretion, which act on sub-epithelial nerve ends, activating the enteric nervous system. However, we identified an epithelial cell that expresses NKAIN4, a neuronal protein associated with the β-subunit of Na+/K+-ATPase. This cell overexpresses Na+/K+-ATPase and ouabain-insensitive Na+-ATPase, enzymes involved in active sodium transport. NKAIN4-positive cells also express neuronal markers as NeuN, acetylcholine-esterase, acetylcholine-transferase, α3- and α7-subunits of ACh receptors, glutamic-decarboxylase, and serotonin-receptor-7, suggesting they are neurons. NKAIN4-positive cells show a polarized shape with an oval body, an apical process finished in a knob-like terminal in contact with the lumen, a basal cilia body at the base of the apical extension, and basal axon-like soma projections connecting sub-epithelial nerve terminals, lymphoid nodules, glial cells, and enterochromaffin cells, forming a network that reaches the epithelial surface. We also showed, using retrograde labeling and immunofluorescence, that these cells receive afferent signals from the enteric nervous system. Finally, we demonstrated that acetylcholine activates NKAIN4-positive cells inducing Ca2+ mobilization and probably serotonin secretion in enterochromaffin cells. NKAIN4-positive cells are neurons that would form a part of a duodenal sensory network for physiological or noxious luminal stimuli." @default.
- W4387326466 created "2023-10-05" @default.
- W4387326466 creator A5007750770 @default.
- W4387326466 creator A5053589990 @default.
- W4387326466 creator A5058212236 @default.
- W4387326466 date "2023-10-04" @default.
- W4387326466 modified "2023-10-14" @default.
- W4387326466 title "Enteric Nervous System: Identification of a Novel Neuronal Sensory Network in the Duodenal Epithelium" @default.
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- W4387326466 doi "https://doi.org/10.1369/00221554231203038" @default.
- W4387326466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37791513" @default.
- W4387326466 hasPublicationYear "2023" @default.