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• W4387330149 abstract "Background: Endometrial cancer is the most common gynecological cancer in developed countries. With recent advances in equipment and knowledge, minimally invasive surgery (MIS) is widely accepted for the treatment of endometrial cancer. This study had the largest number of cases to date in Taiwan, comparing outcomes between MIS and laparotomy staging surgery using real-world data with long-term follow up. Methods: We retrospectively reviewed patients with clinical stage 1 endometrial cancer from 2009 to 2020 in our institute. All patients underwent comprehensive surgical staging procedures by MIS or laparotomy. The safety, morbidity, progression-free survival, and overall survival rates of the two groups were compared. Clinical and pathologic factors were compared with Chi-square and Fisher's Exact Test. Progression-free (PFS) and overall survival (OS) were estimated by the Kaplan-Meier method. Differences between survival curves were analyzed using the log-rank test. A p-value less than 0.05 was considered statistically significant. Using Cox proportional hazards models, all factors found to be significantly associated with risk of recurrence on univariate analyses were then assessed together through multivariable models, resulting in a final oncologic outcome between MIS and laparotomy. Results: 665 cases (412 cases in MIS group and 253 cases in laparotomy group) were enrolled for data analysis. Median operation time was shorter in MIS group (244 and 265 minutes, p <0.001). Median blood loss was also less (75 and 430 mL, p <0.001). Median postoperative hospitalization duration was longer in the laparotomy group (2 and 7 days, p =0.001). After adjusting pre-surgery risk factors, the PFS and OS were no significant difference in MIS and laparotomy groups. Conclusion: Using real-world data with long-term follow up, we could confirm excellent PFS and OS in selective patients with clinical stage 1 endometrial carcinoma who received MIS, and the surgical time, hospital day and blood loss were also less." @default.
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• W4387330149 date "2023-10-04" @default.
• W4387330149 modified "2023-10-06" @default.
• W4387330149 title "Long-term outcome of minimally invasive staging surgery for clinical stage I endometrial cancer: A single institute experience in Taiwan" @default.
• W4387330149 doi "https://doi.org/10.1097/jcma.0000000000001006" @default.
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