Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387330312> ?p ?o ?g. }
- W4387330312 abstract "Abstract Background Bcl-3 is a member of the IκB protein family and an essential modulator of NF-κB activity. It is well established that Bcl-3 is critical for the normal development, survival and differentiation of adaptive immune cells, especially T cells. However, the regulation of immune cell function by Bcl-3 through metabolic pathways has rarely been studied. Results In this study, we explored the role of Bcl-3 in the metabolism and function of T cells via the mTOR pathway. We verified that the proliferation of Bcl-3-deficient Jurkat T cells was inhibited, but their activation was promoted, and Bcl-3 depletion regulated cellular energy metabolism by reducing intracellular ATP and ROS production levels and mitochondrial membrane potential. Bcl-3 also regulates cellular energy metabolism in naive CD4 + T cells. In addition, the knockout of Bcl-3 altered the expression of mTOR, Akt, and Raptor, which are metabolism-related genes, in Jurkat cells. Conclusions This finding indicates that Bcl-3 may mediate the energy metabolism of T cells through the mTOR pathway, thereby affecting their function. Overall, we provide novel insights into the regulatory role of Bcl-3 in T-cell energy metabolism for the prevention and treatment of immune diseases." @default.
- W4387330312 created "2023-10-05" @default.
- W4387330312 creator A5001873592 @default.
- W4387330312 creator A5002151497 @default.
- W4387330312 creator A5004612404 @default.
- W4387330312 creator A5023314511 @default.
- W4387330312 creator A5027572690 @default.
- W4387330312 creator A5044301848 @default.
- W4387330312 creator A5062530071 @default.
- W4387330312 creator A5065852087 @default.
- W4387330312 creator A5090366405 @default.
- W4387330312 date "2023-10-04" @default.
- W4387330312 modified "2023-10-07" @default.
- W4387330312 title "Bcl-3 regulates T cell function through energy metabolism" @default.
- W4387330312 cites W1501353843 @default.
- W4387330312 cites W1509641772 @default.
- W4387330312 cites W1524549627 @default.
- W4387330312 cites W1944753949 @default.
- W4387330312 cites W1963232095 @default.
- W4387330312 cites W1965052314 @default.
- W4387330312 cites W1996235861 @default.
- W4387330312 cites W1999195849 @default.
- W4387330312 cites W2006962735 @default.
- W4387330312 cites W2008136040 @default.
- W4387330312 cites W2014219207 @default.
- W4387330312 cites W2033938945 @default.
- W4387330312 cites W2056721231 @default.
- W4387330312 cites W2065099606 @default.
- W4387330312 cites W2066063938 @default.
- W4387330312 cites W2072393783 @default.
- W4387330312 cites W2073025161 @default.
- W4387330312 cites W2080100938 @default.
- W4387330312 cites W2084561923 @default.
- W4387330312 cites W2086282324 @default.
- W4387330312 cites W2097259163 @default.
- W4387330312 cites W2098873809 @default.
- W4387330312 cites W2106234467 @default.
- W4387330312 cites W2111566945 @default.
- W4387330312 cites W2116016878 @default.
- W4387330312 cites W2127063807 @default.
- W4387330312 cites W2142004326 @default.
- W4387330312 cites W2142492088 @default.
- W4387330312 cites W2147263332 @default.
- W4387330312 cites W2152028923 @default.
- W4387330312 cites W2166332777 @default.
- W4387330312 cites W2250476961 @default.
- W4387330312 cites W225292687 @default.
- W4387330312 cites W2304868333 @default.
- W4387330312 cites W2593250177 @default.
- W4387330312 cites W2620769476 @default.
- W4387330312 cites W2624186887 @default.
- W4387330312 cites W2784241489 @default.
- W4387330312 cites W2799743239 @default.
- W4387330312 cites W2804899347 @default.
- W4387330312 cites W2806380844 @default.
- W4387330312 cites W2865681264 @default.
- W4387330312 cites W3011014170 @default.
- W4387330312 cites W3086384774 @default.
- W4387330312 cites W3137645650 @default.
- W4387330312 cites W3200219681 @default.
- W4387330312 doi "https://doi.org/10.1186/s12865-023-00570-3" @default.
- W4387330312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37794349" @default.
- W4387330312 hasPublicationYear "2023" @default.
- W4387330312 type Work @default.
- W4387330312 citedByCount "0" @default.
- W4387330312 crossrefType "journal-article" @default.
- W4387330312 hasAuthorship W4387330312A5001873592 @default.
- W4387330312 hasAuthorship W4387330312A5002151497 @default.
- W4387330312 hasAuthorship W4387330312A5004612404 @default.
- W4387330312 hasAuthorship W4387330312A5023314511 @default.
- W4387330312 hasAuthorship W4387330312A5027572690 @default.
- W4387330312 hasAuthorship W4387330312A5044301848 @default.
- W4387330312 hasAuthorship W4387330312A5062530071 @default.
- W4387330312 hasAuthorship W4387330312A5065852087 @default.
- W4387330312 hasAuthorship W4387330312A5090366405 @default.
- W4387330312 hasBestOaLocation W43873303121 @default.
- W4387330312 hasConcept C179464577 @default.
- W4387330312 hasConcept C203014093 @default.
- W4387330312 hasConcept C2776090121 @default.
- W4387330312 hasConcept C28859421 @default.
- W4387330312 hasConcept C55493867 @default.
- W4387330312 hasConcept C62112901 @default.
- W4387330312 hasConcept C62478195 @default.
- W4387330312 hasConcept C75217442 @default.
- W4387330312 hasConcept C79879829 @default.
- W4387330312 hasConcept C86554907 @default.
- W4387330312 hasConcept C86803240 @default.
- W4387330312 hasConcept C8891405 @default.
- W4387330312 hasConcept C95444343 @default.
- W4387330312 hasConceptScore W4387330312C179464577 @default.
- W4387330312 hasConceptScore W4387330312C203014093 @default.
- W4387330312 hasConceptScore W4387330312C2776090121 @default.
- W4387330312 hasConceptScore W4387330312C28859421 @default.
- W4387330312 hasConceptScore W4387330312C55493867 @default.
- W4387330312 hasConceptScore W4387330312C62112901 @default.
- W4387330312 hasConceptScore W4387330312C62478195 @default.
- W4387330312 hasConceptScore W4387330312C75217442 @default.
- W4387330312 hasConceptScore W4387330312C79879829 @default.
- W4387330312 hasConceptScore W4387330312C86554907 @default.
- W4387330312 hasConceptScore W4387330312C86803240 @default.