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- W4387330788 startingPage "e1010990" @default.
- W4387330788 abstract "Genetic triggers for sex determination are frequently co-inherited with other linked genes that may also influence one or more sex-specific phenotypes. To better understand how sex-limited regions evolve and function, we studied a small W chromosome-specific region of the frog Xenopus laevis that contains only three genes (dm-w, scan-w, ccdc69-w) and that drives female differentiation. Using gene editing, we found that the sex-determining function of this region requires dm-w but that scan-w and ccdc69-w are not essential for viability, female development, or fertility. Analysis of mesonephros+gonad transcriptomes during sexual differentiation illustrates masculinization of the dm-w knockout transcriptome, and identifies mostly non-overlapping sets of differentially expressed genes in separate knockout lines for each of these three W-specific gene compared to wildtype sisters. Capture sequencing of almost all Xenopus species and PCR surveys indicate that the female-determining function of dm-w is present in only a subset of species that carry this gene. These findings map out a dynamic evolutionary history of a newly evolved W chromosome-specific genomic region, whose components have distinctive functions that frequently degraded during Xenopus diversification, and evidence the evolutionary consequences of recombination suppression." @default.
- W4387330788 created "2023-10-05" @default.
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- W4387330788 date "2023-10-04" @default.
- W4387330788 modified "2023-10-18" @default.
- W4387330788 title "Functional dissection and assembly of a small, newly evolved, W chromosome-specific genomic region of the African clawed frog Xenopus laevis" @default.
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- W4387330788 doi "https://doi.org/10.1371/journal.pgen.1010990" @default.
- W4387330788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37792893" @default.
- W4387330788 hasPublicationYear "2023" @default.
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