Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387331362> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4387331362 abstract "The development and function of the brain requires N-linked glycosylation of proteins, which is a ubiquitous modification in the secretory pathway. N-glycans have a distinct composition and undergo tight regulation in the brain, but the spatial distribution of these structures remains relatively unexplored. Here, we systematically employed carbohydrate binding lectins with differing specificities to various classes of N-glycans and appropriate controls to identify glycan expression in multiple regions of the mouse brain. Lectins binding high-mannose-type N-glycans, the most abundant class of brain N-glycans, showed diffuse staining with some punctate structures observed on high magnification. Lectins binding specific motifs of complex N-glycans, including fucose and bisecting GlcNAc, showed more partitioned labeling, including to the synapse-rich molecular layer of the cerebellum. Understanding the spatial distribution of N-glycans across the brain will aid future studies of these critical protein modifications in development and disease of the brain." @default.
- W4387331362 created "2023-10-05" @default.
- W4387331362 creator A5023341393 @default.
- W4387331362 creator A5040017166 @default.
- W4387331362 creator A5053290894 @default.
- W4387331362 date "2023-10-04" @default.
- W4387331362 modified "2023-10-06" @default.
- W4387331362 title "N-glycans show distinct spatial distribution in mouse brain" @default.
- W4387331362 doi "https://doi.org/10.1093/glycob/cwad077" @default.
- W4387331362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37792804" @default.
- W4387331362 hasPublicationYear "2023" @default.
- W4387331362 type Work @default.
- W4387331362 citedByCount "0" @default.
- W4387331362 crossrefType "journal-article" @default.
- W4387331362 hasAuthorship W4387331362A5023341393 @default.
- W4387331362 hasAuthorship W4387331362A5040017166 @default.
- W4387331362 hasAuthorship W4387331362A5053290894 @default.
- W4387331362 hasConcept C108625454 @default.
- W4387331362 hasConcept C156293190 @default.
- W4387331362 hasConcept C185592680 @default.
- W4387331362 hasConcept C206212055 @default.
- W4387331362 hasConcept C2776841590 @default.
- W4387331362 hasConcept C2777313579 @default.
- W4387331362 hasConcept C2779212266 @default.
- W4387331362 hasConcept C2780758401 @default.
- W4387331362 hasConcept C55493867 @default.
- W4387331362 hasConcept C70721500 @default.
- W4387331362 hasConcept C86803240 @default.
- W4387331362 hasConcept C95444343 @default.
- W4387331362 hasConceptScore W4387331362C108625454 @default.
- W4387331362 hasConceptScore W4387331362C156293190 @default.
- W4387331362 hasConceptScore W4387331362C185592680 @default.
- W4387331362 hasConceptScore W4387331362C206212055 @default.
- W4387331362 hasConceptScore W4387331362C2776841590 @default.
- W4387331362 hasConceptScore W4387331362C2777313579 @default.
- W4387331362 hasConceptScore W4387331362C2779212266 @default.
- W4387331362 hasConceptScore W4387331362C2780758401 @default.
- W4387331362 hasConceptScore W4387331362C55493867 @default.
- W4387331362 hasConceptScore W4387331362C70721500 @default.
- W4387331362 hasConceptScore W4387331362C86803240 @default.
- W4387331362 hasConceptScore W4387331362C95444343 @default.
- W4387331362 hasLocation W43873313621 @default.
- W4387331362 hasLocation W43873313622 @default.
- W4387331362 hasOpenAccess W4387331362 @default.
- W4387331362 hasPrimaryLocation W43873313621 @default.
- W4387331362 hasRelatedWork W2002120802 @default.
- W4387331362 hasRelatedWork W2008842285 @default.
- W4387331362 hasRelatedWork W2028984335 @default.
- W4387331362 hasRelatedWork W2129373464 @default.
- W4387331362 hasRelatedWork W2209907559 @default.
- W4387331362 hasRelatedWork W2775271973 @default.
- W4387331362 hasRelatedWork W2911013070 @default.
- W4387331362 hasRelatedWork W3087561948 @default.
- W4387331362 hasRelatedWork W3176331455 @default.
- W4387331362 hasRelatedWork W3216067888 @default.
- W4387331362 isParatext "false" @default.
- W4387331362 isRetracted "false" @default.
- W4387331362 workType "article" @default.