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- W4387331363 abstract "System x c - , encoded by Slc7a11 , is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as glutathione. Glutathione acts as a co-factor for enzymes responsible for scavenging reactive oxygen species. Upon exposure to bacterial products, macrophages exhibit a rapid upregulation of system x c - . This study investigates the impact of Slc7a11 deficiency on the functionality of peritoneal and bone marrow-derived macrophages. Our findings reveal that the absence of Slc7a11 results in significantly reduced glutathione levels, compromised mitochondrial flexibility, and hindered cytokine production in bone marrow-derived macrophages. Conversely, system x c - has a lesser impact on peritoneal macrophages in vivo . These results indicate that system x c - is essential for maintaining glutathione levels, mitochondrial functionality, and cytokine production, with a heightened importance under atmospheric oxygen tension." @default.
- W4387331363 created "2023-10-05" @default.
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- W4387331363 date "2023-10-04" @default.
- W4387331363 modified "2023-10-16" @default.
- W4387331363 title "Cystine/Glutamate antiporter system xc- deficiency impairs macrophage glutathione metabolism and cytokine production" @default.
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- W4387331363 doi "https://doi.org/10.1371/journal.pone.0291950" @default.
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