Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387331502> ?p ?o ?g. }
- W4387331502 endingPage "e0291305" @default.
- W4387331502 startingPage "e0291305" @default.
- W4387331502 abstract "A substantial body of evidence points to the heritability of dietary preferences. While vegetarianism has been practiced for millennia in various societies, its practitioners remain a small minority of people worldwide, and the role of genetics in choosing a vegetarian diet is not well understood. Dietary choices involve an interplay between the physiologic effects of dietary items, their metabolism, and taste perception, all of which are strongly influenced by genetics. In this study, we used a genome-wide association study (GWAS) to identify loci associated with strict vegetarianism in UK Biobank participants. Comparing 5,324 strict vegetarians to 329,455 controls, we identified one SNP on chromosome 18 that is associated with vegetarianism at the genome-wide significant level (rs72884519, β = -0.11, P = 4.997 x 10 −8 ), and an additional 201 suggestively significant variants. Four genes are associated with rs72884519: TMEM241 , RIOK3 , NPC1 , and RMC1 . Using the Functional Mapping and Annotation (FUMA) platform and the Multi-marker Analysis of GenoMic Annotation (MAGMA) tool, we identified 34 genes with a possible role in vegetarianism, 3 of which are GWAS-significant based on gene-level analysis: RIOK3 , RMC1 , and NPC1 . Several of the genes associated with vegetarianism, including TMEM241 , NPC1 , and RMC1 , have important functions in lipid metabolism and brain function, raising the possibility that differences in lipid metabolism and their effects on the brain may underlie the ability to subsist on a vegetarian diet. These results support a role for genetics in choosing a vegetarian diet and open the door to future studies aimed at further elucidating the physiologic pathways involved in vegetarianism." @default.
- W4387331502 created "2023-10-05" @default.
- W4387331502 creator A5000534819 @default.
- W4387331502 creator A5007696387 @default.
- W4387331502 creator A5042245279 @default.
- W4387331502 creator A5056948570 @default.
- W4387331502 creator A5071655032 @default.
- W4387331502 date "2023-10-04" @default.
- W4387331502 modified "2023-10-16" @default.
- W4387331502 title "Genetics of vegetarianism: A genome-wide association study" @default.
- W4387331502 cites W1005872966 @default.
- W4387331502 cites W1614139721 @default.
- W4387331502 cites W1860778844 @default.
- W4387331502 cites W1915760953 @default.
- W4387331502 cites W1967383774 @default.
- W4387331502 cites W1975674164 @default.
- W4387331502 cites W1980749094 @default.
- W4387331502 cites W1983726739 @default.
- W4387331502 cites W199204758 @default.
- W4387331502 cites W1993629096 @default.
- W4387331502 cites W1998430907 @default.
- W4387331502 cites W2015926651 @default.
- W4387331502 cites W2017677597 @default.
- W4387331502 cites W2020245832 @default.
- W4387331502 cites W2024071435 @default.
- W4387331502 cites W2026324678 @default.
- W4387331502 cites W2045191455 @default.
- W4387331502 cites W2051190798 @default.
- W4387331502 cites W2051314902 @default.
- W4387331502 cites W2064092786 @default.
- W4387331502 cites W2064817029 @default.
- W4387331502 cites W2066565254 @default.
- W4387331502 cites W2076154138 @default.
- W4387331502 cites W2076715146 @default.
- W4387331502 cites W2079299463 @default.
- W4387331502 cites W2080379646 @default.
- W4387331502 cites W2081526231 @default.
- W4387331502 cites W2082484806 @default.
- W4387331502 cites W2082704080 @default.
- W4387331502 cites W2095317019 @default.
- W4387331502 cites W2111307685 @default.
- W4387331502 cites W2117566834 @default.
- W4387331502 cites W2124558555 @default.
- W4387331502 cites W2125620567 @default.
- W4387331502 cites W2134893181 @default.
- W4387331502 cites W2136116905 @default.
- W4387331502 cites W2139615060 @default.
- W4387331502 cites W2141820415 @default.
- W4387331502 cites W2146156622 @default.
- W4387331502 cites W2147165617 @default.
- W4387331502 cites W2153860431 @default.
- W4387331502 cites W2159046673 @default.
- W4387331502 cites W2160995259 @default.
- W4387331502 cites W2165126457 @default.
- W4387331502 cites W2166267940 @default.
- W4387331502 cites W2166514780 @default.
- W4387331502 cites W2167432685 @default.
- W4387331502 cites W2171282210 @default.
- W4387331502 cites W2216458865 @default.
- W4387331502 cites W2293464703 @default.
- W4387331502 cites W2317934215 @default.
- W4387331502 cites W2395579158 @default.
- W4387331502 cites W2396636851 @default.
- W4387331502 cites W2399602220 @default.
- W4387331502 cites W2435003465 @default.
- W4387331502 cites W2474161690 @default.
- W4387331502 cites W2511515754 @default.
- W4387331502 cites W2558597765 @default.
- W4387331502 cites W2580855044 @default.
- W4387331502 cites W263084883 @default.
- W4387331502 cites W2723723801 @default.
- W4387331502 cites W2744732181 @default.
- W4387331502 cites W2766025148 @default.
- W4387331502 cites W2770092353 @default.
- W4387331502 cites W2806870298 @default.
- W4387331502 cites W2895486342 @default.
- W4387331502 cites W2899274153 @default.
- W4387331502 cites W2921896440 @default.
- W4387331502 cites W2947959833 @default.
- W4387331502 cites W2950099124 @default.
- W4387331502 cites W2962979703 @default.
- W4387331502 cites W2978997620 @default.
- W4387331502 cites W2995971356 @default.
- W4387331502 cites W2998569056 @default.
- W4387331502 cites W3014044510 @default.
- W4387331502 cites W3083152849 @default.
- W4387331502 cites W3096343466 @default.
- W4387331502 cites W3097041662 @default.
- W4387331502 cites W3125283227 @default.
- W4387331502 cites W3161471341 @default.
- W4387331502 cites W3171186941 @default.
- W4387331502 cites W3176947590 @default.
- W4387331502 cites W3210226777 @default.
- W4387331502 cites W3212335724 @default.
- W4387331502 cites W3214562433 @default.
- W4387331502 cites W4200490636 @default.
- W4387331502 cites W4220888336 @default.
- W4387331502 cites W4225596786 @default.