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- W4387331864 startingPage "rna.079821.123" @default.
- W4387331864 abstract "The characterization of the conformational landscape of the RNA backbone is rather complex due to the ability of RNA to assume a big variety of conformations. These backbone conformations can be depicted by pseudo-torsional angles linking RNA backbone atoms, from which Ramachandran-like plots can be built. We explored here different definitions of these pseudo-torsional angles, finding that the most accurate ones are the traditional η (eta) and θ (theta) angles, which represent the relative position of RNA backbone atoms P and C4'. We explore the distribution of η-θ in known experimental structures, comparing the pseudo-torsional space generated with structures determined exclusively by one experimental technique. We found that the complete picture only appears when combining data from different sources. The maps provide a quite comprehensive representation of the RNA accessible space, which can be used in RNA-structural prediction. Finally, our results highlight that protein interactions lead to significant changes in the population of the η-θ space, pointing towards the role of induced-fit mechanisms in protein-RNA recognition." @default.
- W4387331864 created "2023-10-05" @default.
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- W4387331864 date "2023-10-04" @default.
- W4387331864 modified "2023-10-06" @default.
- W4387331864 title "The Pseudo-Torsional Space of RNA" @default.
- W4387331864 doi "https://doi.org/10.1261/rna.079821.123" @default.
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