Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387332005> ?p ?o ?g. }
- W4387332005 abstract "Abstract Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work has identified that TXNIP has a far wider range of additional roles: from regulating glucose and lipid metabolism, to cell cycle arrest and inflammation. Its expression is increased by stressors commonly found in neoplastic cells and the wider tumor microenvironment (TME), and, as such, TXNIP has been extensively studied in cancers. In this review, we evaluate the current literature regarding the regulation and the function of TXNIP, highlighting its emerging role in modulating signaling between different cell types within the TME. We then assess current and future translational opportunities and the associated challenges in this area. An improved understanding of the functions and mechanisms of TXNIP in cancers may enhance its suitability as a therapeutic target." @default.
- W4387332005 created "2023-10-05" @default.
- W4387332005 creator A5010245558 @default.
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- W4387332005 creator A5042543722 @default.
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- W4387332005 creator A5068070067 @default.
- W4387332005 creator A5093000318 @default.
- W4387332005 date "2023-10-04" @default.
- W4387332005 modified "2023-10-17" @default.
- W4387332005 title "The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control" @default.
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