Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387332580> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4387332580 abstract "Starting from the easily prepared 1‐(pyridin‐2‐yl)‐ or 1‐(4‐chloropyridin‐2‐yl)ethan‐1‐ones bearer of different substituents (cyclohexyl, phenyl, pyridin‐2‐yl) in the position 2, the corresponding primary pyridinic ethanamines have been synthesized in very high enantiomeric excesses (ee ≥ 97%). The strategy involves a highly enantioselective ketoreductase (KRED) catalyzed reduction, mesylation of the resulting optically active alcohol followed by nucleophilic substitution with azide anion and, finally, reduction of the azide function. Some of these pyridinic amines obtained in such manner are precursors of biologically active compounds such as Ontazolast." @default.
- W4387332580 created "2023-10-05" @default.
- W4387332580 creator A5007289632 @default.
- W4387332580 creator A5010978926 @default.
- W4387332580 creator A5093000406 @default.
- W4387332580 date "2023-10-04" @default.
- W4387332580 modified "2023-10-14" @default.
- W4387332580 title "An Efficient Chemoenzymatic Route towards Biologically Active Pyridinic Amines" @default.
- W4387332580 doi "https://doi.org/10.1002/ejoc.202300808" @default.
- W4387332580 hasPublicationYear "2023" @default.
- W4387332580 type Work @default.
- W4387332580 citedByCount "0" @default.
- W4387332580 crossrefType "journal-article" @default.
- W4387332580 hasAuthorship W4387332580A5007289632 @default.
- W4387332580 hasAuthorship W4387332580A5010978926 @default.
- W4387332580 hasAuthorship W4387332580A5093000406 @default.
- W4387332580 hasConcept C116073593 @default.
- W4387332580 hasConcept C135731615 @default.
- W4387332580 hasConcept C146686406 @default.
- W4387332580 hasConcept C161790260 @default.
- W4387332580 hasConcept C178790620 @default.
- W4387332580 hasConcept C178907741 @default.
- W4387332580 hasConcept C185592680 @default.
- W4387332580 hasConcept C202751555 @default.
- W4387332580 hasConcept C21951064 @default.
- W4387332580 hasConcept C2780997848 @default.
- W4387332580 hasConcept C2781066024 @default.
- W4387332580 hasConcept C3019471444 @default.
- W4387332580 hasConcept C3141732 @default.
- W4387332580 hasConcept C41183919 @default.
- W4387332580 hasConcept C486523 @default.
- W4387332580 hasConcept C55493867 @default.
- W4387332580 hasConcept C71240020 @default.
- W4387332580 hasConceptScore W4387332580C116073593 @default.
- W4387332580 hasConceptScore W4387332580C135731615 @default.
- W4387332580 hasConceptScore W4387332580C146686406 @default.
- W4387332580 hasConceptScore W4387332580C161790260 @default.
- W4387332580 hasConceptScore W4387332580C178790620 @default.
- W4387332580 hasConceptScore W4387332580C178907741 @default.
- W4387332580 hasConceptScore W4387332580C185592680 @default.
- W4387332580 hasConceptScore W4387332580C202751555 @default.
- W4387332580 hasConceptScore W4387332580C21951064 @default.
- W4387332580 hasConceptScore W4387332580C2780997848 @default.
- W4387332580 hasConceptScore W4387332580C2781066024 @default.
- W4387332580 hasConceptScore W4387332580C3019471444 @default.
- W4387332580 hasConceptScore W4387332580C3141732 @default.
- W4387332580 hasConceptScore W4387332580C41183919 @default.
- W4387332580 hasConceptScore W4387332580C486523 @default.
- W4387332580 hasConceptScore W4387332580C55493867 @default.
- W4387332580 hasConceptScore W4387332580C71240020 @default.
- W4387332580 hasLocation W43873325801 @default.
- W4387332580 hasOpenAccess W4387332580 @default.
- W4387332580 hasPrimaryLocation W43873325801 @default.
- W4387332580 hasRelatedWork W1956888186 @default.
- W4387332580 hasRelatedWork W1995889183 @default.
- W4387332580 hasRelatedWork W1997522209 @default.
- W4387332580 hasRelatedWork W1998197617 @default.
- W4387332580 hasRelatedWork W2082797880 @default.
- W4387332580 hasRelatedWork W2101751655 @default.
- W4387332580 hasRelatedWork W2949708017 @default.
- W4387332580 hasRelatedWork W2951708424 @default.
- W4387332580 hasRelatedWork W2951769123 @default.
- W4387332580 hasRelatedWork W2952381534 @default.
- W4387332580 isParatext "false" @default.
- W4387332580 isRetracted "false" @default.
- W4387332580 workType "article" @default.