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- W4387333872 abstract "Spontaneous protein crystallization is a rare event, yet needle-shaped protein crystals are frequently found in eosinophil-rich inflammation. In humans, Charcot-Leyden crystals (CLCs) are made from galectin-10 (Gal10) protein, an abundant protein in eosinophils.Whereas mice do not encode Gal10 in their genome, they do form pseudo-CLCs, made from the chitinase-like proteins Ym1 and/or Ym2, encoded by Chil3 and Chil4 and made by myeloid and epithelial cells respectively. Here, we investigated the biological effects of pseudo-CLCs since their function is currently unknown.We produced recombinant Ym1 crystals which were shown to have identical crystal packing and structure by X-ray crystallography as in vivo native crystals derived from murine lung. When administered to the airways of mice, crystalline but not soluble Ym1 stimulated innate and adaptive immunity and acted as a type 2 immune adjuvant for eosinophilic inflammation via triggering of dendritic cells (DCs).Murine Ym1 protein crystals found at sites of eosinophilic inflammation reinforce type 2 immunity and could serve as a surrogate model for studying the biology of human CLCs.Protein crystallization is exceedingly rare, yet here, Heyndrickx et al. show that Ym1 crystals made from the chitinase like protein Chil3 promote type 2 immunity in mice." @default.
- W4387333872 created "2023-10-05" @default.
- W4387333872 date "2023-10-04" @default.
- W4387333872 modified "2023-10-05" @default.
- W4387333872 title "Reviewer #2 (Public Review): Ym1 protein crystals promote type 2 immunity" @default.
- W4387333872 doi "https://doi.org/10.7554/elife.90676.1.sa2" @default.
- W4387333872 hasPublicationYear "2023" @default.
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