Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387334671> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4387334671 abstract "Xiaoqinglong decoction (XQLD) is widely used clinically in the treatment of childhood cough variant asthma (CVA). However, its potential mechanism is still unknown. In the present study, we investigate the biological network and signaling pathway of XQLD in treatment of childhood CVA using network pharmacology-based analysis and experimental validation. By using the Bioinformatics Analysis Tool Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM) database, we confirmed the correlation between XQLD and asthma, and we screened 1338 potential target genes of Mahuang and Guizhi, the most active herbs in XQLD. By overlapping “Childhood asthma-related genes” of DisGeNET database, we identified 58 intersecting genes of Childhood asthma and 1338 target genes of Mahuang and Guizhi. The intersecting genes were used to construct the protein-to-protein interaction (PPI) and performed Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. GO enrichment analysis demonstrated 359 Biological Process terms, 16 Cellular Component terms, and 26 Molecular Function terms. Meantime, 75 terms of KEGG signaling pathway were involved in enrichment analysis. These candidates showed a significant correlation with inflammatory response and positive regulation of tyrosine phosphorylation of STAT protein. In addition, XQLD treatment significantly upregulated serum IFN-γ expression, and downregulated serum IL-6 expression of CVA mice. XQLD treatment significantly inhibited phosphorylation of STAT3 in bronchial-lung tissues. Our data suggest that XQLD effectively alleviated bronchial-lung tissue damage in CVA mice and inhibited the body inflammatory response by regulating IL-6/STAT3 signaling pathway." @default.
- W4387334671 created "2023-10-05" @default.
- W4387334671 creator A5030400998 @default.
- W4387334671 creator A5040040812 @default.
- W4387334671 creator A5069277158 @default.
- W4387334671 creator A5082273041 @default.
- W4387334671 date "2023-10-05" @default.
- W4387334671 modified "2023-10-14" @default.
- W4387334671 title "Xiaoqinglong decoction suppresses childhood cough variant asthma and inhibited the body inflammatory response by regulating IL-6/STAT3 signaling pathway" @default.
- W4387334671 doi "https://doi.org/10.1097/ms9.0000000000001326" @default.
- W4387334671 hasPublicationYear "2023" @default.
- W4387334671 type Work @default.
- W4387334671 citedByCount "0" @default.
- W4387334671 crossrefType "journal-article" @default.
- W4387334671 hasAuthorship W4387334671A5030400998 @default.
- W4387334671 hasAuthorship W4387334671A5040040812 @default.
- W4387334671 hasAuthorship W4387334671A5069277158 @default.
- W4387334671 hasAuthorship W4387334671A5082273041 @default.
- W4387334671 hasBestOaLocation W43873346711 @default.
- W4387334671 hasConcept C104317684 @default.
- W4387334671 hasConcept C11960822 @default.
- W4387334671 hasConcept C142724271 @default.
- W4387334671 hasConcept C150194340 @default.
- W4387334671 hasConcept C152724338 @default.
- W4387334671 hasConcept C188947578 @default.
- W4387334671 hasConcept C190409667 @default.
- W4387334671 hasConcept C203014093 @default.
- W4387334671 hasConcept C204787440 @default.
- W4387334671 hasConcept C2776042228 @default.
- W4387334671 hasConcept C2778923194 @default.
- W4387334671 hasConcept C2987395477 @default.
- W4387334671 hasConcept C54355233 @default.
- W4387334671 hasConcept C556039675 @default.
- W4387334671 hasConcept C60644358 @default.
- W4387334671 hasConcept C62478195 @default.
- W4387334671 hasConcept C71924100 @default.
- W4387334671 hasConcept C86803240 @default.
- W4387334671 hasConcept C98274493 @default.
- W4387334671 hasConceptScore W4387334671C104317684 @default.
- W4387334671 hasConceptScore W4387334671C11960822 @default.
- W4387334671 hasConceptScore W4387334671C142724271 @default.
- W4387334671 hasConceptScore W4387334671C150194340 @default.
- W4387334671 hasConceptScore W4387334671C152724338 @default.
- W4387334671 hasConceptScore W4387334671C188947578 @default.
- W4387334671 hasConceptScore W4387334671C190409667 @default.
- W4387334671 hasConceptScore W4387334671C203014093 @default.
- W4387334671 hasConceptScore W4387334671C204787440 @default.
- W4387334671 hasConceptScore W4387334671C2776042228 @default.
- W4387334671 hasConceptScore W4387334671C2778923194 @default.
- W4387334671 hasConceptScore W4387334671C2987395477 @default.
- W4387334671 hasConceptScore W4387334671C54355233 @default.
- W4387334671 hasConceptScore W4387334671C556039675 @default.
- W4387334671 hasConceptScore W4387334671C60644358 @default.
- W4387334671 hasConceptScore W4387334671C62478195 @default.
- W4387334671 hasConceptScore W4387334671C71924100 @default.
- W4387334671 hasConceptScore W4387334671C86803240 @default.
- W4387334671 hasConceptScore W4387334671C98274493 @default.
- W4387334671 hasLocation W43873346711 @default.
- W4387334671 hasOpenAccess W4387334671 @default.
- W4387334671 hasPrimaryLocation W43873346711 @default.
- W4387334671 hasRelatedWork W1987603245 @default.
- W4387334671 hasRelatedWork W2021523535 @default.
- W4387334671 hasRelatedWork W2044470373 @default.
- W4387334671 hasRelatedWork W2153802529 @default.
- W4387334671 hasRelatedWork W2381595426 @default.
- W4387334671 hasRelatedWork W2748644580 @default.
- W4387334671 hasRelatedWork W2754087939 @default.
- W4387334671 hasRelatedWork W4205963003 @default.
- W4387334671 hasRelatedWork W4290465784 @default.
- W4387334671 hasRelatedWork W4366698666 @default.
- W4387334671 isParatext "false" @default.
- W4387334671 isRetracted "false" @default.
- W4387334671 workType "article" @default.