FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387338898> ?p ?o ?g. }

• W4387338898 abstract "ABSTRACT Brain water homeostasis provides not only physical protection, but also determines the diffusion of chemical molecules key for information processing and metabolic stability. As a major type of glial cell in the brain parenchyma, astrocytes are the dominant cell type expressing aquaporin water channels. However, how astrocyte aquaporin contributes to brain water homeostasis remains to be understood. We report here that astrocyte aquaporin 4 (AQP4) mediates a tonic water efflux in basal conditions. Acute inhibition of astrocyte AQP4 leads to intracellular water accumulation as optically resolved by fluorescence-translated imaging in acute brain slices, and in vivo by fiber photometry in moving mice. We then show that the tonic aquaporin water efflux maintains astrocyte volume equilibrium, astrocyte and neuron Ca 2+ signaling, and extracellular space remodeling during optogenetically induced cortical spreading depression. Using diffusion-weighted magnetic resonance imaging (DW-MRI), we observed that in vivo inhibition of AQP4 water efflux heterogeneously disturbs brain water homeostasis in a region-dependent manner. Our data suggest that astrocyte aquaporin, though bidirectional in nature, mediates a tonic water outflow to sustain cellular and environmental equilibrium in brain parenchyma. Significance statement Our brain is immersed, thus protected, in a water environment. It ensures intra– and extracellular molecular diffusion, which is vital for brain function and health. Brain water homeostasis is maintained by dynamic water transport between different cell types. Astrocytes are a main type of glial cell widely distributed in brain parenchyma, and are also the primary cell type expressing the bidirectional aquaporin water channel. Here we show that in basal conditions, aquaporin channel mediates a tonic water efflux from astrocytes. This mechanism maintains astrocyte volume stability, activity-gated brain parenchyma remodeling and brain water homeostasis. Our finding sheds light on how astrocytes regulate water states in the brain, and will help to understand brain homeostasis in specific life context." @default.
• W4387338898 created "2023-10-05" @default.
• W4387338898 creator A5007938185 @default.
• W4387338898 creator A5021092199 @default.
• W4387338898 creator A5037520334 @default.
• W4387338898 creator A5050954254 @default.
• W4387338898 creator A5053471168 @default.
• W4387338898 creator A5061815235 @default.
• W4387338898 creator A5063861942 @default.
• W4387338898 creator A5075191346 @default.
• W4387338898 creator A5077444063 @default.
• W4387338898 creator A5082997007 @default.
• W4387338898 date "2023-10-03" @default.
• W4387338898 modified "2023-10-12" @default.
• W4387338898 title "Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasis" @default.
• W4387338898 cites W1490831218 @default.
• W4387338898 cites W1857174369 @default.
• W4387338898 cites W1937363507 @default.
• W4387338898 cites W1941392759 @default.
• W4387338898 cites W1980829307 @default.
• W4387338898 cites W1984390450 @default.
• W4387338898 cites W2021786044 @default.
• W4387338898 cites W2022494564 @default.
• W4387338898 cites W2024055161 @default.
• W4387338898 cites W2024720661 @default.
• W4387338898 cites W2040574649 @default.
• W4387338898 cites W2045459991 @default.
• W4387338898 cites W2060701169 @default.
• W4387338898 cites W2063001897 @default.
• W4387338898 cites W2070441580 @default.
• W4387338898 cites W2078102941 @default.
• W4387338898 cites W2101183816 @default.
• W4387338898 cites W2114560189 @default.
• W4387338898 cites W2119734225 @default.
• W4387338898 cites W2119987649 @default.
• W4387338898 cites W2127621191 @default.
• W4387338898 cites W2134330663 @default.
• W4387338898 cites W2134483650 @default.
• W4387338898 cites W2142676565 @default.
• W4387338898 cites W2157256907 @default.
• W4387338898 cites W2162423225 @default.
• W4387338898 cites W2584813339 @default.
• W4387338898 cites W2659271799 @default.
• W4387338898 cites W2746870493 @default.
• W4387338898 cites W2751474624 @default.
• W4387338898 cites W2754982612 @default.
• W4387338898 cites W2767482362 @default.
• W4387338898 cites W2789376055 @default.
• W4387338898 cites W2789414817 @default.
• W4387338898 cites W2790139801 @default.
• W4387338898 cites W2900410080 @default.
• W4387338898 cites W2901166225 @default.
• W4387338898 cites W2917065384 @default.
• W4387338898 cites W2939200041 @default.
• W4387338898 cites W2964353729 @default.
• W4387338898 cites W2964849669 @default.
• W4387338898 cites W3025780063 @default.
• W4387338898 cites W3033510746 @default.
• W4387338898 cites W3035784645 @default.
• W4387338898 cites W3044413849 @default.
• W4387338898 cites W3153948176 @default.
• W4387338898 cites W3159077390 @default.
• W4387338898 cites W3191403583 @default.
• W4387338898 cites W3199243439 @default.
• W4387338898 cites W3204223030 @default.
• W4387338898 cites W4225986765 @default.
• W4387338898 cites W4293037333 @default.
• W4387338898 cites W4300979007 @default.
• W4387338898 cites W4310938039 @default.
• W4387338898 cites W4318615442 @default.
• W4387338898 cites W4319656932 @default.
• W4387338898 cites W4380991857 @default.
• W4387338898 doi "https://doi.org/10.1101/2023.10.03.560471" @default.
• W4387338898 hasPublicationYear "2023" @default.
• W4387338898 type Work @default.
• W4387338898 citedByCount "0" @default.
• W4387338898 crossrefType "posted-content" @default.
• W4387338898 hasAuthorship W4387338898A5007938185 @default.
• W4387338898 hasAuthorship W4387338898A5021092199 @default.
• W4387338898 hasAuthorship W4387338898A5037520334 @default.
• W4387338898 hasAuthorship W4387338898A5050954254 @default.
• W4387338898 hasAuthorship W4387338898A5053471168 @default.
• W4387338898 hasAuthorship W4387338898A5061815235 @default.
• W4387338898 hasAuthorship W4387338898A5063861942 @default.
• W4387338898 hasAuthorship W4387338898A5075191346 @default.
• W4387338898 hasAuthorship W4387338898A5077444063 @default.
• W4387338898 hasAuthorship W4387338898A5082997007 @default.
• W4387338898 hasBestOaLocation W43873388981 @default.
• W4387338898 hasConcept C12554922 @default.
• W4387338898 hasConcept C127413603 @default.
• W4387338898 hasConcept C154280991 @default.
• W4387338898 hasConcept C15755913 @default.
• W4387338898 hasConcept C169760540 @default.
• W4387338898 hasConcept C185592680 @default.
• W4387338898 hasConcept C196822366 @default.
• W4387338898 hasConcept C200082930 @default.
• W4387338898 hasConcept C2777542381 @default.
• W4387338898 hasConcept C28406088 @default.
• W4387338898 hasConcept C2988574769 @default.
• W4387338898 hasConcept C2992163139 @default.

• next