Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387339103> ?p ?o ?g. }
- W4387339103 endingPage "123233" @default.
- W4387339103 startingPage "123233" @default.
- W4387339103 abstract "The self-assembly process of proteins provides plenty of potential for redesigning and combining them into supramolecular assemblies for real-time applications. The present study demonstrates the encapsulation of dietary polyphenol rutin in β-casein (βCN) micellar cavity followed by their molecular interactions and biological implications. The prepared rutin-loaded βCN particles (DLS: 274.2±3.86 nm; TEM: ∼200 nm) appeared to be smoothly spherical. Isothermal titration calorimetry (ITC) studies indicated that the encapsulation process was thermodynamically favorable and a typical example of entropy-driven hydrophobic interaction (ΔH: 38.1 kJ mol-1; TΔS = 51.9 kJ mol-1 K-1). The molecular interaction of rutin with βCN was characterized by absorption, steady-state fluorescence, and time-resolved fluorescence spectroscopic studies. The intrinsic fluorescence of βCN was quenched by rutin via a static mechanism with a favorable binding affinity. Molecular docking studies suggested the involvement of hydrophobic and hydrogen bonding interactions between the concerned entities. A sustained release mechanism followed by significant improvement in the cytotoxicity of rutin was observed after encapsulation. An in vitro digestion model mimicking gastric and intestinal phases was also employed to study the bioaccessibility. Our study may assist in formulating more efficient casein-based carrier systems to enhance the bio-efficacy of polyphenols." @default.
- W4387339103 created "2023-10-05" @default.
- W4387339103 creator A5009932226 @default.
- W4387339103 creator A5026493384 @default.
- W4387339103 creator A5045273325 @default.
- W4387339103 creator A5048780217 @default.
- W4387339103 creator A5053545678 @default.
- W4387339103 creator A5081623542 @default.
- W4387339103 creator A5089093513 @default.
- W4387339103 date "2023-12-01" @default.
- W4387339103 modified "2023-10-16" @default.
- W4387339103 title "Milk protein-based carrier system for encapsulation of dietary polyphenol rutin: molecular-level interactions and enhanced bioactivities" @default.
- W4387339103 cites W1539670244 @default.
- W4387339103 cites W1766076157 @default.
- W4387339103 cites W1970109998 @default.
- W4387339103 cites W1987134040 @default.
- W4387339103 cites W2003658245 @default.
- W4387339103 cites W2009841111 @default.
- W4387339103 cites W2012378838 @default.
- W4387339103 cites W2055834145 @default.
- W4387339103 cites W2075705506 @default.
- W4387339103 cites W2088156304 @default.
- W4387339103 cites W2090385545 @default.
- W4387339103 cites W2307448996 @default.
- W4387339103 cites W2334614976 @default.
- W4387339103 cites W2582922860 @default.
- W4387339103 cites W2899421849 @default.
- W4387339103 cites W2952979599 @default.
- W4387339103 cites W2960677631 @default.
- W4387339103 cites W2972647384 @default.
- W4387339103 cites W2980045791 @default.
- W4387339103 cites W2997918511 @default.
- W4387339103 cites W3007826174 @default.
- W4387339103 cites W3011551089 @default.
- W4387339103 cites W3013294291 @default.
- W4387339103 cites W3095620416 @default.
- W4387339103 cites W3099762274 @default.
- W4387339103 cites W3102683423 @default.
- W4387339103 cites W3106942664 @default.
- W4387339103 cites W3115268040 @default.
- W4387339103 cites W3138994978 @default.
- W4387339103 cites W3146013771 @default.
- W4387339103 cites W3182912889 @default.
- W4387339103 cites W3184839555 @default.
- W4387339103 cites W3198114034 @default.
- W4387339103 cites W4296507801 @default.
- W4387339103 cites W4315864729 @default.
- W4387339103 doi "https://doi.org/10.1016/j.molliq.2023.123233" @default.
- W4387339103 hasPublicationYear "2023" @default.
- W4387339103 type Work @default.
- W4387339103 citedByCount "0" @default.
- W4387339103 crossrefType "journal-article" @default.
- W4387339103 hasAuthorship W4387339103A5009932226 @default.
- W4387339103 hasAuthorship W4387339103A5026493384 @default.
- W4387339103 hasAuthorship W4387339103A5045273325 @default.
- W4387339103 hasAuthorship W4387339103A5048780217 @default.
- W4387339103 hasAuthorship W4387339103A5053545678 @default.
- W4387339103 hasAuthorship W4387339103A5081623542 @default.
- W4387339103 hasAuthorship W4387339103A5089093513 @default.
- W4387339103 hasBestOaLocation W43873391031 @default.
- W4387339103 hasConcept C112887158 @default.
- W4387339103 hasConcept C121332964 @default.
- W4387339103 hasConcept C12554922 @default.
- W4387339103 hasConcept C147789679 @default.
- W4387339103 hasConcept C156911925 @default.
- W4387339103 hasConcept C178790620 @default.
- W4387339103 hasConcept C185592680 @default.
- W4387339103 hasConcept C2775963812 @default.
- W4387339103 hasConcept C2776142715 @default.
- W4387339103 hasConcept C2778004101 @default.
- W4387339103 hasConcept C32909587 @default.
- W4387339103 hasConcept C43617362 @default.
- W4387339103 hasConcept C62520636 @default.
- W4387339103 hasConcept C70899900 @default.
- W4387339103 hasConcept C86803240 @default.
- W4387339103 hasConcept C90260826 @default.
- W4387339103 hasConcept C91881484 @default.
- W4387339103 hasConcept C93275456 @default.
- W4387339103 hasConceptScore W4387339103C112887158 @default.
- W4387339103 hasConceptScore W4387339103C121332964 @default.
- W4387339103 hasConceptScore W4387339103C12554922 @default.
- W4387339103 hasConceptScore W4387339103C147789679 @default.
- W4387339103 hasConceptScore W4387339103C156911925 @default.
- W4387339103 hasConceptScore W4387339103C178790620 @default.
- W4387339103 hasConceptScore W4387339103C185592680 @default.
- W4387339103 hasConceptScore W4387339103C2775963812 @default.
- W4387339103 hasConceptScore W4387339103C2776142715 @default.
- W4387339103 hasConceptScore W4387339103C2778004101 @default.
- W4387339103 hasConceptScore W4387339103C32909587 @default.
- W4387339103 hasConceptScore W4387339103C43617362 @default.
- W4387339103 hasConceptScore W4387339103C62520636 @default.
- W4387339103 hasConceptScore W4387339103C70899900 @default.
- W4387339103 hasConceptScore W4387339103C86803240 @default.
- W4387339103 hasConceptScore W4387339103C90260826 @default.
- W4387339103 hasConceptScore W4387339103C91881484 @default.
- W4387339103 hasConceptScore W4387339103C93275456 @default.
- W4387339103 hasLocation W43873391031 @default.
- W4387339103 hasOpenAccess W4387339103 @default.