FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387340133> ?p ?o ?g. }

• W4387340133 abstract ": Graft-versus host disease (GvHD) is one of the major limitations to allogeneic hematopoietic stem cell transplantation (HCT). While corticosteroids with calcineurin inhibitors are established first line-therapy for chronic graft-versus host disease (cGvHD), approximately half of cGvHD patients are refractory to corticosteroid therapy. : The goal of the present study was to compare treatment outcomes of patients treated with extracorporeal photophoresis (ECP) and best available therapy (BAT) as third-line or beyond treatment for cGvHD. : Using propensity-score matching (PSM), treatment outcomes were compared between ECP-treated patients (n=74) and a historical cohort of cGvHD patients treated with BAT (n=132). By adjusting for unbalanced risk factors between the groups, including GvHD severity at therapy start, acute GvHD history, and baseline corticosteroid dose, 62 patients were balanced and selected for PSM. : In the PSM cohort, the ECP group showed 70.1% 12 months’ failure-free survival (FFS) rate vs 32.5% in the BAT group (p<0.0001, HR 0.214), and 93.1% 12 months’ overall survival (OS) rate vs 68.1% in the BAT group (p=0.0249, HR 0.3811); multivariate analysis confirmed ECP's superior FFS and OS over BAT. General linear model analysis showed faster tapering of corticosteroids in the ECP vs BAT PSM groups in the first 6 months, and higher rates of prednisone discontinuation; the ECP group had a greater percent prednisone discontinuation by 6%, 14.9% and 22.5% at months 0, 3, and 6, respectively. : The current study demonstrates superior FFS, OS and steroid tapering efficacy for ECP vs BAT as third-line therapy or beyond in cGvHD patients." @default.
• W4387340133 created "2023-10-05" @default.
• W4387340133 creator A5007851794 @default.
• W4387340133 creator A5014346242 @default.
• W4387340133 creator A5017586094 @default.
• W4387340133 creator A5038048073 @default.
• W4387340133 creator A5040159118 @default.
• W4387340133 creator A5045426037 @default.
• W4387340133 creator A5045765371 @default.
• W4387340133 creator A5051261755 @default.
• W4387340133 creator A5071646305 @default.
• W4387340133 creator A5072952978 @default.
• W4387340133 creator A5073179735 @default.
• W4387340133 creator A5080055664 @default.
• W4387340133 creator A5084708084 @default.
• W4387340133 creator A5089636175 @default.
• W4387340133 creator A5092544337 @default.
• W4387340133 date "2023-10-01" @default.
• W4387340133 modified "2023-10-16" @default.
• W4387340133 title "Propensity score matching analysis comparing the efficacy and steroid tapering benefit of extracorporeal photopheresis to best available therapy in third-line or beyond treatment for chronic GvHD" @default.
• W4387340133 cites W1649554656 @default.
• W4387340133 cites W1965249571 @default.
• W4387340133 cites W1966429220 @default.
• W4387340133 cites W1980924218 @default.
• W4387340133 cites W2015809954 @default.
• W4387340133 cites W2044560944 @default.
• W4387340133 cites W2045216488 @default.
• W4387340133 cites W2055313377 @default.
• W4387340133 cites W2104476614 @default.
• W4387340133 cites W2121960517 @default.
• W4387340133 cites W2128812336 @default.
• W4387340133 cites W2150291618 @default.
• W4387340133 cites W2160666689 @default.
• W4387340133 cites W2379365975 @default.
• W4387340133 cites W2515189678 @default.
• W4387340133 cites W2528448343 @default.
• W4387340133 cites W2740060821 @default.
• W4387340133 cites W3004031232 @default.
• W4387340133 cites W3125696196 @default.
• W4387340133 cites W3180640300 @default.
• W4387340133 cites W3201332485 @default.
• W4387340133 cites W4240754354 @default.
• W4387340133 cites W4247737273 @default.
• W4387340133 doi "https://doi.org/10.1016/j.jtct.2023.09.021" @default.
• W4387340133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37797719" @default.
• W4387340133 hasPublicationYear "2023" @default.
• W4387340133 type Work @default.
• W4387340133 citedByCount "0" @default.
• W4387340133 crossrefType "journal-article" @default.
• W4387340133 hasAuthorship W4387340133A5007851794 @default.
• W4387340133 hasAuthorship W4387340133A5014346242 @default.
• W4387340133 hasAuthorship W4387340133A5017586094 @default.
• W4387340133 hasAuthorship W4387340133A5038048073 @default.
• W4387340133 hasAuthorship W4387340133A5040159118 @default.
• W4387340133 hasAuthorship W4387340133A5045426037 @default.
• W4387340133 hasAuthorship W4387340133A5045765371 @default.
• W4387340133 hasAuthorship W4387340133A5051261755 @default.
• W4387340133 hasAuthorship W4387340133A5071646305 @default.
• W4387340133 hasAuthorship W4387340133A5072952978 @default.
• W4387340133 hasAuthorship W4387340133A5073179735 @default.
• W4387340133 hasAuthorship W4387340133A5080055664 @default.
• W4387340133 hasAuthorship W4387340133A5084708084 @default.
• W4387340133 hasAuthorship W4387340133A5089636175 @default.
• W4387340133 hasAuthorship W4387340133A5092544337 @default.
• W4387340133 hasBestOaLocation W43873401331 @default.
• W4387340133 hasConcept C114138010 @default.
• W4387340133 hasConcept C121684516 @default.
• W4387340133 hasConcept C126322002 @default.
• W4387340133 hasConcept C128057223 @default.
• W4387340133 hasConcept C141071460 @default.
• W4387340133 hasConcept C142424586 @default.
• W4387340133 hasConcept C17923572 @default.
• W4387340133 hasConcept C2776804153 @default.
• W4387340133 hasConcept C2777408962 @default.
• W4387340133 hasConcept C2778715236 @default.
• W4387340133 hasConcept C2778720950 @default.
• W4387340133 hasConcept C2779972918 @default.
• W4387340133 hasConcept C2911091166 @default.
• W4387340133 hasConcept C41008148 @default.
• W4387340133 hasConcept C71924100 @default.
• W4387340133 hasConcept C72563966 @default.
• W4387340133 hasConcept C86803240 @default.
• W4387340133 hasConcept C87355193 @default.
• W4387340133 hasConceptScore W4387340133C114138010 @default.
• W4387340133 hasConceptScore W4387340133C121684516 @default.
• W4387340133 hasConceptScore W4387340133C126322002 @default.
• W4387340133 hasConceptScore W4387340133C128057223 @default.
• W4387340133 hasConceptScore W4387340133C141071460 @default.
• W4387340133 hasConceptScore W4387340133C142424586 @default.
• W4387340133 hasConceptScore W4387340133C17923572 @default.
• W4387340133 hasConceptScore W4387340133C2776804153 @default.
• W4387340133 hasConceptScore W4387340133C2777408962 @default.
• W4387340133 hasConceptScore W4387340133C2778715236 @default.
• W4387340133 hasConceptScore W4387340133C2778720950 @default.
• W4387340133 hasConceptScore W4387340133C2779972918 @default.
• W4387340133 hasConceptScore W4387340133C2911091166 @default.
• W4387340133 hasConceptScore W4387340133C41008148 @default.
• W4387340133 hasConceptScore W4387340133C71924100 @default.
• W4387340133 hasConceptScore W4387340133C72563966 @default.
• W4387340133 hasConceptScore W4387340133C86803240 @default.

• next