FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387341458> ?p ?o ?g. }

• W4387341458 endingPage "100814" @default.
• W4387341458 startingPage "100814" @default.
• W4387341458 abstract "Infection and inflammation are two key features to consider to avoid septic or aseptic loosening of bone-implanted biomaterials. In this context, various approaches to fine-tune the biomaterial's properties have been studied in order to modulate the crosstalk between immune and skeletal cells. Cation-doping strategies for tuning of calcium phosphates properties has been evidenced as a promising way to control the biomaterial-induced inflammatory process, and thus improving their osteoimmunomodulatory properties. Copper(II) ions are recognized for their antibacterial potential, but the literature on their impact on particulate material-induced acute inflammation is scarce. We synthesized copper(II) ions-doped biphasic calcium phosphate (BCP), intended to exhibit osteoimmunomodulatory properties. We addressed in vitro, for the first time, the inflammatory response of human primary polymorphonuclear neutrophils (PMNs) to copper(II) ions-doped or undoped (BCP) powders, synthesized by an original and robust wet method, in the presence or absence of LPS as a costimulant to mimic an infectious environment. ELISA and zymography allowed us to evidence, in vitro, a specific increase in IL-8 and GRO-α secretion but not MIP-1β, TNF-α, or MMP-9, by PMNs. To assess in vivo relevance of these findings, we used a mouse air pouch model. Thanks to flow cytometry analysis, we highlighted an increased PMN recruitment with the copper(II) ions-doped samples compared to undoped samples. The immunomodulatory effect of copper(II) ions-doped BCP powders and the consequent induced moderate level of inflammation may promote bacterial clearance by PMNs in addition to the antimicrobial potential of the material. Copper(II) doping provides new insights into calcium phosphate (CaP)-based biomaterials for prosthesis coating or bone reconstruction by effectively modulating the inflammatory environment." @default.
• W4387341458 created "2023-10-05" @default.
• W4387341458 creator A5000640262 @default.
• W4387341458 creator A5003087837 @default.
• W4387341458 creator A5012494956 @default.
• W4387341458 creator A5017868802 @default.
• W4387341458 creator A5023572908 @default.
• W4387341458 creator A5028507346 @default.
• W4387341458 creator A5049185751 @default.
• W4387341458 creator A5051401628 @default.
• W4387341458 creator A5056102504 @default.
• W4387341458 creator A5057516970 @default.
• W4387341458 creator A5061794210 @default.
• W4387341458 creator A5066748427 @default.
• W4387341458 creator A5070116215 @default.
• W4387341458 creator A5089983506 @default.
• W4387341458 date "2023-12-01" @default.
• W4387341458 modified "2023-10-18" @default.
• W4387341458 title "The acute inflammatory response to copper(II)-doped biphasic calcium phosphates" @default.
• W4387341458 cites W1538447709 @default.
• W4387341458 cites W1548853895 @default.
• W4387341458 cites W155930765 @default.
• W4387341458 cites W1600880529 @default.
• W4387341458 cites W1846776373 @default.
• W4387341458 cites W1965120562 @default.
• W4387341458 cites W1981129120 @default.
• W4387341458 cites W1984418189 @default.
• W4387341458 cites W1993600146 @default.
• W4387341458 cites W1994052858 @default.
• W4387341458 cites W1994625357 @default.
• W4387341458 cites W1997839876 @default.
• W4387341458 cites W2010388697 @default.
• W4387341458 cites W2012655169 @default.
• W4387341458 cites W2025529246 @default.
• W4387341458 cites W2027099852 @default.
• W4387341458 cites W2045616069 @default.
• W4387341458 cites W2049021149 @default.
• W4387341458 cites W2052396720 @default.
• W4387341458 cites W2075957187 @default.
• W4387341458 cites W2079509436 @default.
• W4387341458 cites W2089040209 @default.
• W4387341458 cites W2092925736 @default.
• W4387341458 cites W2099884403 @default.
• W4387341458 cites W2103197347 @default.
• W4387341458 cites W2107051907 @default.
• W4387341458 cites W2116210034 @default.
• W4387341458 cites W2135423586 @default.
• W4387341458 cites W2144832079 @default.
• W4387341458 cites W2144960155 @default.
• W4387341458 cites W2180393982 @default.
• W4387341458 cites W2517252856 @default.
• W4387341458 cites W2520287758 @default.
• W4387341458 cites W2559709338 @default.
• W4387341458 cites W2734556200 @default.
• W4387341458 cites W2766570900 @default.
• W4387341458 cites W2784103179 @default.
• W4387341458 cites W2912043101 @default.
• W4387341458 cites W2975580135 @default.
• W4387341458 cites W2995083410 @default.
• W4387341458 cites W2999298912 @default.
• W4387341458 cites W3048710083 @default.
• W4387341458 cites W3090410405 @default.
• W4387341458 cites W3109015633 @default.
• W4387341458 cites W3134132096 @default.
• W4387341458 cites W3158257332 @default.
• W4387341458 cites W3193646489 @default.
• W4387341458 cites W35347323 @default.
• W4387341458 cites W4255418630 @default.
• W4387341458 cites W4293793364 @default.
• W4387341458 cites W4323854389 @default.
• W4387341458 doi "https://doi.org/10.1016/j.mtbio.2023.100814" @default.
• W4387341458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37841800" @default.
• W4387341458 hasPublicationYear "2023" @default.
• W4387341458 type Work @default.
• W4387341458 citedByCount "0" @default.
• W4387341458 crossrefType "journal-article" @default.
• W4387341458 hasAuthorship W4387341458A5000640262 @default.
• W4387341458 hasAuthorship W4387341458A5003087837 @default.
• W4387341458 hasAuthorship W4387341458A5012494956 @default.
• W4387341458 hasAuthorship W4387341458A5017868802 @default.
• W4387341458 hasAuthorship W4387341458A5023572908 @default.
• W4387341458 hasAuthorship W4387341458A5028507346 @default.
• W4387341458 hasAuthorship W4387341458A5049185751 @default.
• W4387341458 hasAuthorship W4387341458A5051401628 @default.
• W4387341458 hasAuthorship W4387341458A5056102504 @default.
• W4387341458 hasAuthorship W4387341458A5057516970 @default.
• W4387341458 hasAuthorship W4387341458A5061794210 @default.
• W4387341458 hasAuthorship W4387341458A5066748427 @default.
• W4387341458 hasAuthorship W4387341458A5070116215 @default.
• W4387341458 hasAuthorship W4387341458A5089983506 @default.
• W4387341458 hasBestOaLocation W43873414581 @default.
• W4387341458 hasConcept C150903083 @default.
• W4387341458 hasConcept C171250308 @default.
• W4387341458 hasConcept C185592680 @default.
• W4387341458 hasConcept C191897082 @default.
• W4387341458 hasConcept C192562407 @default.
• W4387341458 hasConcept C202751555 @default.
• W4387341458 hasConcept C203014093 @default.

• next