Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387341749> ?p ?o ?g. }
- W4387341749 abstract "Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which the viral genome became embedded as a dormant regulatory element within the host germline. When ERVs become activated, they comprehensively rewire genomic regulatory networks of the host and facilitate critical developmental events, such as preimplantation development and placentation, in a manner specific to species, developmental stage, and tissues. However, accumulating evidence suggests that aberrant ERV transcription compromises genome stability and has been implicated in cellular senescence and various pathogenic processes, underscoring the significance of host genomic surveillance mechanisms. Here, we revisit the prominent functions of ERVs in early development and highlight their emerging roles in mammalian post-implantation development and organogenesis. We also discuss their implications for aging and pathological processes such as microbial infection, immune response. Furthermore, we discuss recent advances in stem-cell-based models, single-cell omics, and genome editing technologies, which serve as beacons illuminating the versatile nature of ERVs in mammalian development and health." @default.
- W4387341749 created "2023-10-05" @default.
- W4387341749 creator A5010546900 @default.
- W4387341749 creator A5023269476 @default.
- W4387341749 creator A5062969034 @default.
- W4387341749 creator A5080915717 @default.
- W4387341749 date "2023-10-01" @default.
- W4387341749 modified "2023-10-08" @default.
- W4387341749 title "Endogenous retroviruses in development and health" @default.
- W4387341749 cites W1113174486 @default.
- W4387341749 cites W1491910236 @default.
- W4387341749 cites W1602429548 @default.
- W4387341749 cites W1905278501 @default.
- W4387341749 cites W1942805176 @default.
- W4387341749 cites W1953890763 @default.
- W4387341749 cites W1965247392 @default.
- W4387341749 cites W1975643185 @default.
- W4387341749 cites W1980923315 @default.
- W4387341749 cites W1984890118 @default.
- W4387341749 cites W1984986688 @default.
- W4387341749 cites W1986504960 @default.
- W4387341749 cites W1989482679 @default.
- W4387341749 cites W2011861577 @default.
- W4387341749 cites W2031333605 @default.
- W4387341749 cites W2041813032 @default.
- W4387341749 cites W2045148364 @default.
- W4387341749 cites W2052389749 @default.
- W4387341749 cites W2057061886 @default.
- W4387341749 cites W2057519261 @default.
- W4387341749 cites W2057931534 @default.
- W4387341749 cites W2068878293 @default.
- W4387341749 cites W2069059761 @default.
- W4387341749 cites W2078418147 @default.
- W4387341749 cites W2089023364 @default.
- W4387341749 cites W2097789141 @default.
- W4387341749 cites W2098378506 @default.
- W4387341749 cites W2104778396 @default.
- W4387341749 cites W2106431826 @default.
- W4387341749 cites W2108794690 @default.
- W4387341749 cites W2115959782 @default.
- W4387341749 cites W2116710635 @default.
- W4387341749 cites W2121429599 @default.
- W4387341749 cites W2134228703 @default.
- W4387341749 cites W2135410542 @default.
- W4387341749 cites W2140496675 @default.
- W4387341749 cites W2143417442 @default.
- W4387341749 cites W2150453771 @default.
- W4387341749 cites W2151918713 @default.
- W4387341749 cites W2157571263 @default.
- W4387341749 cites W2167719208 @default.
- W4387341749 cites W2236767140 @default.
- W4387341749 cites W2281104217 @default.
- W4387341749 cites W2281262354 @default.
- W4387341749 cites W2318777795 @default.
- W4387341749 cites W2579329060 @default.
- W4387341749 cites W2602350359 @default.
- W4387341749 cites W2617882125 @default.
- W4387341749 cites W2623088659 @default.
- W4387341749 cites W2754064102 @default.
- W4387341749 cites W2755096673 @default.
- W4387341749 cites W2782152502 @default.
- W4387341749 cites W2791066734 @default.
- W4387341749 cites W2801872537 @default.
- W4387341749 cites W2809237949 @default.
- W4387341749 cites W2883220169 @default.
- W4387341749 cites W2884899270 @default.
- W4387341749 cites W2890774414 @default.
- W4387341749 cites W2896454092 @default.
- W4387341749 cites W2903149641 @default.
- W4387341749 cites W2936448388 @default.
- W4387341749 cites W2942093796 @default.
- W4387341749 cites W2962425929 @default.
- W4387341749 cites W2992551893 @default.
- W4387341749 cites W3004950593 @default.
- W4387341749 cites W3013146062 @default.
- W4387341749 cites W3014137533 @default.
- W4387341749 cites W3015549321 @default.
- W4387341749 cites W3026549348 @default.
- W4387341749 cites W3047416382 @default.
- W4387341749 cites W3089588814 @default.
- W4387341749 cites W3096832851 @default.
- W4387341749 cites W3103755024 @default.
- W4387341749 cites W3112986012 @default.
- W4387341749 cites W3119544327 @default.
- W4387341749 cites W3129642593 @default.
- W4387341749 cites W3135900624 @default.
- W4387341749 cites W3136917711 @default.
- W4387341749 cites W3157549151 @default.
- W4387341749 cites W3161508292 @default.
- W4387341749 cites W3162125475 @default.
- W4387341749 cites W3162697935 @default.
- W4387341749 cites W3165418622 @default.
- W4387341749 cites W3173442783 @default.
- W4387341749 cites W3175735655 @default.
- W4387341749 cites W3179758880 @default.
- W4387341749 cites W3180363056 @default.
- W4387341749 cites W3184922706 @default.
- W4387341749 cites W4210902500 @default.
- W4387341749 cites W4214672693 @default.
- W4387341749 cites W4220700100 @default.