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- W4387341770 abstract "A ligation protocol has been developed in which a peptide containing an N-terminal serine is linked via its side-chain alcohol to the C-terminal carboxylate of a second peptide by Mitsunobu esterification. N-Deprotection of the serine and subsequent exposure to a weak amine base triggers O-to-N acyl transfer, delivering the desired ligation product. A unique aspect of this strategy is the use of the C-terminal carboxylate as a nucleophile rather than as an electrophile. As a result, the ligation occurs without evidence of epimerization. A broad scope of C-terminal nucleophiles is tolerated, including proline and hindered beta-branched residues." @default.
- W4387341770 created "2023-10-05" @default.
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- W4387341770 date "2023-10-04" @default.
- W4387341770 modified "2023-10-06" @default.
- W4387341770 title "A Serine Ligation Method Based on Mitsunobu Reaction and O-to-N Acyl Transfer" @default.
- W4387341770 doi "https://doi.org/10.26434/chemrxiv-2023-49gtb" @default.
- W4387341770 hasPublicationYear "2023" @default.
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