Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387342322> ?p ?o ?g. }
- W4387342322 endingPage "1411" @default.
- W4387342322 startingPage "1411" @default.
- W4387342322 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors, characterized by its aggressive tumor biology and poor prognosis. While immune checkpoint inhibitors (ICIs) play a major part in the treatment algorithm of various solid tumors, there is still no evidence of clinical benefit from ICI in patients with metastatic PDAC (mPDAC). This might be due to several reasons, such as the inherent low immunogenicity of pancreatic cancer, the dense stroma-rich tumor microenvironment that precludes an efficient migration of antitumoral effector T cells to the cancer cells, and the increased proportion of immunosuppressive immune cells, such as regulatory T cells (Tregs), cancer-associated fibroblasts (CAFs), and myeloid-derived suppressor cells (MDSCs), facilitating tumor growth and invasion. In this review, we provide an overview of the current state of ICIs in mPDAC, report on the biological rationale to implement ICIs into the treatment strategy of pancreatic cancer, and discuss preclinical studies and clinical trials in this field. Additionally, we shed light on the challenges of implementing ICIs into the treatment strategy of PDAC and discuss potential future directions." @default.
- W4387342322 created "2023-10-05" @default.
- W4387342322 creator A5051725106 @default.
- W4387342322 creator A5069558924 @default.
- W4387342322 creator A5090904511 @default.
- W4387342322 date "2023-10-04" @default.
- W4387342322 modified "2023-10-06" @default.
- W4387342322 title "The Role of Immune Checkpoint Inhibitors in Metastatic Pancreatic Cancer: Current State and Outlook" @default.
- W4387342322 cites W1931508686 @default.
- W4387342322 cites W1968812902 @default.
- W4387342322 cites W1986608185 @default.
- W4387342322 cites W1996912024 @default.
- W4387342322 cites W1997944395 @default.
- W4387342322 cites W2019035934 @default.
- W4387342322 cites W2031960993 @default.
- W4387342322 cites W2034573495 @default.
- W4387342322 cites W2039105461 @default.
- W4387342322 cites W2041888585 @default.
- W4387342322 cites W2043991982 @default.
- W4387342322 cites W2044363258 @default.
- W4387342322 cites W2052727153 @default.
- W4387342322 cites W2055091294 @default.
- W4387342322 cites W2060425936 @default.
- W4387342322 cites W2063982677 @default.
- W4387342322 cites W2076743146 @default.
- W4387342322 cites W2086834665 @default.
- W4387342322 cites W2088110734 @default.
- W4387342322 cites W2088812649 @default.
- W4387342322 cites W2100519108 @default.
- W4387342322 cites W2100928937 @default.
- W4387342322 cites W2101653483 @default.
- W4387342322 cites W2106728539 @default.
- W4387342322 cites W2106837613 @default.
- W4387342322 cites W2107748627 @default.
- W4387342322 cites W2122041824 @default.
- W4387342322 cites W2129741568 @default.
- W4387342322 cites W2130819559 @default.
- W4387342322 cites W2145248653 @default.
- W4387342322 cites W2151253787 @default.
- W4387342322 cites W2154753744 @default.
- W4387342322 cites W2165480504 @default.
- W4387342322 cites W2233614027 @default.
- W4387342322 cites W2270057672 @default.
- W4387342322 cites W2288738065 @default.
- W4387342322 cites W2293645537 @default.
- W4387342322 cites W2299118744 @default.
- W4387342322 cites W2324865626 @default.
- W4387342322 cites W2403400382 @default.
- W4387342322 cites W2416038770 @default.
- W4387342322 cites W2469223980 @default.
- W4387342322 cites W2505222127 @default.
- W4387342322 cites W2512217706 @default.
- W4387342322 cites W2560628113 @default.
- W4387342322 cites W2578888194 @default.
- W4387342322 cites W2592502078 @default.
- W4387342322 cites W2593969873 @default.
- W4387342322 cites W2604266511 @default.
- W4387342322 cites W2612422316 @default.
- W4387342322 cites W2621755511 @default.
- W4387342322 cites W2751587238 @default.
- W4387342322 cites W2757828780 @default.
- W4387342322 cites W2766814660 @default.
- W4387342322 cites W2767403472 @default.
- W4387342322 cites W2767551096 @default.
- W4387342322 cites W2772923107 @default.
- W4387342322 cites W2781947653 @default.
- W4387342322 cites W2807087106 @default.
- W4387342322 cites W2887449433 @default.
- W4387342322 cites W2891572283 @default.
- W4387342322 cites W2900472144 @default.
- W4387342322 cites W2903623792 @default.
- W4387342322 cites W2904385172 @default.
- W4387342322 cites W2904444972 @default.
- W4387342322 cites W2906111025 @default.
- W4387342322 cites W2910310961 @default.
- W4387342322 cites W2912593557 @default.
- W4387342322 cites W2915455779 @default.
- W4387342322 cites W2917550064 @default.
- W4387342322 cites W2919944461 @default.
- W4387342322 cites W2928276758 @default.
- W4387342322 cites W2931391344 @default.
- W4387342322 cites W2946302521 @default.
- W4387342322 cites W2949375297 @default.
- W4387342322 cites W2952817507 @default.
- W4387342322 cites W2953461318 @default.
- W4387342322 cites W2959096163 @default.
- W4387342322 cites W2968557592 @default.
- W4387342322 cites W2970237571 @default.
- W4387342322 cites W2984359187 @default.
- W4387342322 cites W2988500598 @default.
- W4387342322 cites W2988731068 @default.
- W4387342322 cites W2995903778 @default.
- W4387342322 cites W2996574710 @default.
- W4387342322 cites W3004059930 @default.
- W4387342322 cites W3004443275 @default.
- W4387342322 cites W3005376508 @default.
- W4387342322 cites W3006954450 @default.
- W4387342322 cites W3010711580 @default.