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- W4387343811 abstract "Abstract Patient-derived organoid models of estrogen receptor-positive (ER+) breast cancer would provide a much-needed tool to understand drug resistance and disease progression better. However, the establishment and long-term maintenance of ER expression, function, and response in vitro remains a significant challenge. Here, we report the development of an ER+ breast tumor organoid medium (BTOM-ER) that conserves ER expression, estrogen responsiveness, and dependence, as well as sensitivity to endocrine therapy of ER+ patient-derived xenograft organoids (PDXO). Our findings demonstrate the utility of subtype-specific culture conditions that better mimic the characteristics of the breast epithelial biology and microenvironment, providing a powerful platform for investigating therapy response and disease progression of ER+ breast cancer." @default.
- W4387343811 created "2023-10-05" @default.
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- W4387343811 date "2023-10-04" @default.
- W4387343811 modified "2023-10-06" @default.
- W4387343811 title "Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer" @default.
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- W4387343811 doi "https://doi.org/10.21203/rs.3.rs-3341539/v1" @default.
- W4387343811 hasPublicationYear "2023" @default.
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