Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387343857> ?p ?o ?g. }
- W4387343857 abstract "Abstract As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. Here we show that clathrin-mediated endocytosis and activation of Notch signaling promotes chondrocyte senescence and osteoarthritis development, which is negatively regulated by myosin light chain 3. Myosin light chain 3 (MYL3) protein levels decline sharply in senescent chondrocytes of cartilages from model mice and osteoarthritis (OA) patients. Conditional deletion of Myl3 in chondrocytes significantly promoted, whereas intra-articular injection of adeno-associated virus overexpressing MYL3 delayed, OA progression in male mice. MYL3 deficiency led to enhanced clathrin-mediated endocytosis by promoting the interaction between myosin VI and clathrin, further inducing the internalization of Notch and resulting in activation of Notch signaling in chondrocytes. Pharmacologic blockade of clathrin-mediated endocytosis-Notch signaling prevented MYL3 loss-induced chondrocyte senescence and alleviated OA progression in male mice. Our results establish a previously unknown mechanism essential for cellular senescence and provide a potential therapeutic direction for OA." @default.
- W4387343857 created "2023-10-05" @default.
- W4387343857 creator A5018254630 @default.
- W4387343857 creator A5025195267 @default.
- W4387343857 creator A5033020983 @default.
- W4387343857 creator A5036318725 @default.
- W4387343857 creator A5056032393 @default.
- W4387343857 creator A5057117256 @default.
- W4387343857 creator A5063357134 @default.
- W4387343857 creator A5072524196 @default.
- W4387343857 creator A5074496055 @default.
- W4387343857 creator A5078898813 @default.
- W4387343857 creator A5079132263 @default.
- W4387343857 creator A5049005090 @default.
- W4387343857 date "2023-10-04" @default.
- W4387343857 modified "2023-10-06" @default.
- W4387343857 title "MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling" @default.
- W4387343857 cites W1487036716 @default.
- W4387343857 cites W1585595240 @default.
- W4387343857 cites W1995577585 @default.
- W4387343857 cites W1997666231 @default.
- W4387343857 cites W2023863818 @default.
- W4387343857 cites W2025243746 @default.
- W4387343857 cites W2032691826 @default.
- W4387343857 cites W2033105576 @default.
- W4387343857 cites W2046048202 @default.
- W4387343857 cites W2050291058 @default.
- W4387343857 cites W2053031822 @default.
- W4387343857 cites W2057862712 @default.
- W4387343857 cites W2058693333 @default.
- W4387343857 cites W2068996331 @default.
- W4387343857 cites W2069519394 @default.
- W4387343857 cites W2091007034 @default.
- W4387343857 cites W2098377160 @default.
- W4387343857 cites W2126525177 @default.
- W4387343857 cites W2128404955 @default.
- W4387343857 cites W2130458932 @default.
- W4387343857 cites W2142532042 @default.
- W4387343857 cites W2153045264 @default.
- W4387343857 cites W2157963288 @default.
- W4387343857 cites W2162066500 @default.
- W4387343857 cites W2180648758 @default.
- W4387343857 cites W2193792657 @default.
- W4387343857 cites W2321446349 @default.
- W4387343857 cites W2394631798 @default.
- W4387343857 cites W2582214777 @default.
- W4387343857 cites W2608899726 @default.
- W4387343857 cites W2788548733 @default.
- W4387343857 cites W2793567263 @default.
- W4387343857 cites W2794655698 @default.
- W4387343857 cites W2800413193 @default.
- W4387343857 cites W2887337318 @default.
- W4387343857 cites W2889781076 @default.
- W4387343857 cites W2890584379 @default.
- W4387343857 cites W2903155987 @default.
- W4387343857 cites W2917634600 @default.
- W4387343857 cites W3007959858 @default.
- W4387343857 cites W3101423962 @default.
- W4387343857 cites W3112626852 @default.
- W4387343857 cites W3137959312 @default.
- W4387343857 cites W4211067786 @default.
- W4387343857 doi "https://doi.org/10.1038/s41467-023-41858-7" @default.
- W4387343857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37794006" @default.
- W4387343857 hasPublicationYear "2023" @default.
- W4387343857 type Work @default.
- W4387343857 citedByCount "0" @default.
- W4387343857 crossrefType "journal-article" @default.
- W4387343857 hasAuthorship W4387343857A5018254630 @default.
- W4387343857 hasAuthorship W4387343857A5025195267 @default.
- W4387343857 hasAuthorship W4387343857A5033020983 @default.
- W4387343857 hasAuthorship W4387343857A5036318725 @default.
- W4387343857 hasAuthorship W4387343857A5049005090 @default.
- W4387343857 hasAuthorship W4387343857A5056032393 @default.
- W4387343857 hasAuthorship W4387343857A5057117256 @default.
- W4387343857 hasAuthorship W4387343857A5063357134 @default.
- W4387343857 hasAuthorship W4387343857A5072524196 @default.
- W4387343857 hasAuthorship W4387343857A5074496055 @default.
- W4387343857 hasAuthorship W4387343857A5078898813 @default.
- W4387343857 hasAuthorship W4387343857A5079132263 @default.
- W4387343857 hasBestOaLocation W43873438571 @default.
- W4387343857 hasConcept C105702510 @default.
- W4387343857 hasConcept C139770010 @default.
- W4387343857 hasConcept C1491633281 @default.
- W4387343857 hasConcept C161879069 @default.
- W4387343857 hasConcept C185592680 @default.
- W4387343857 hasConcept C2780550940 @default.
- W4387343857 hasConcept C2781403057 @default.
- W4387343857 hasConcept C28005876 @default.
- W4387343857 hasConcept C522857546 @default.
- W4387343857 hasConcept C55493867 @default.
- W4387343857 hasConcept C62478195 @default.
- W4387343857 hasConcept C63162447 @default.
- W4387343857 hasConcept C6997183 @default.
- W4387343857 hasConcept C86803240 @default.
- W4387343857 hasConcept C95444343 @default.
- W4387343857 hasConceptScore W4387343857C105702510 @default.
- W4387343857 hasConceptScore W4387343857C139770010 @default.
- W4387343857 hasConceptScore W4387343857C1491633281 @default.
- W4387343857 hasConceptScore W4387343857C161879069 @default.
- W4387343857 hasConceptScore W4387343857C185592680 @default.