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• W4387343994 abstract "Abstract Biopolymer condensates often emerge as a multi-droplet state and never coalesce into one large droplet within the experimental timespan. This contradicts the prediction of classical polymer physics which suggests the existence of one large droplet beyond the phase transition. Previous work revealed that the sticker-spacer architecture of biopolymers may dynamically stabilize the multi-droplet state. Here, we simulate the condensate coalescence using metadynamics approach and reveal two distinct physical mechanisms underlying the fusion of droplets. Condensates made of sticker-spacer polymers readily undergo a kinetic arrest when stickers exhibit slow exchange while fast exchanging stickers at similar levels of saturation allow merger to equilibrium states. On the other hand, condensates composed of homopolymers fuse readily until they reach a threshold density. We also show that the inter-condensate exchange of chains offers a general mechanism that drives the fusion. We map the range of mechanisms of kinetic arrest from slow sticker exchange dynamics to density mediated in terms of energetic separation of stickers and spacers. In that vein, our simulations predict that the biological condensates may show a re-entrant dynamic merger behavior at a particular range of sticker-spacer energetics. Mechanistic underpinnings revealed in this work have broader implications in polymer physics and condensate biology." @default.
• W4387343994 created "2023-10-05" @default.
• W4387343994 creator A5069184845 @default.
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• W4387343994 date "2023-10-04" @default.
• W4387343994 modified "2023-10-12" @default.
• W4387343994 title "Separation of sticker-spacer energetics governs the coalescence of biomolecular condensates" @default.
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• W4387343994 doi "https://doi.org/10.1101/2023.10.03.560747" @default.
• W4387343994 hasPublicationYear "2023" @default.
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