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• W4387344584 abstract "Abstract Decreased total CO 2 (tCO 2 ) is significantly associated with all-cause mortality in critically ill patients. Because of a lack of data to evaluate the impact of tCO 2 in patients with COVID-19, we assessed the impact of tCO 2 on all-cause mortality in this study. We retrospectively reviewed the data of hospitalized patients with COVID-19 in two Korean referral hospitals between February 2020 and September 2021. The primary outcome was in-hospital mortality. We assessed the impact of tCO 2 as a continuous variable on mortality using the Cox-proportional hazard model. In addition, we evaluated the relative factors associated with tCO 2 ≤ 22 mmol/L using logistic regression analysis. In 4,423 patients included, the mean tCO 2 was 24.8 ± 3.0 mmol/L, and 17.9% of patients with tCO 2 ≤ 22 mmol/L. An increase in mmol/L of tCO 2 decreased the risk of all-cause mortality by 4.8% after adjustment for age, sex, comorbidities, and laboratory values. Based on 22 mmol/L of tCO 2 , the risk of mortality was 1.7 times higher than that in patients with lower tCO 2 . This result was maintained in the analysis using a cutoff value of tCO 2 24 mmol/L. Higher white blood cell count; lower hemoglobin, serum calcium, and eGFR; and higher uric acid, and aspartate aminotransferase were significantly associated with a tCO 2 value ≤ 22 mmol/L. Decreased tCO 2 significantly increased the risk of all-cause mortality in patients with COVID-19. Monitoring of tCO 2 could be a good indicator to predict prognosis and it needs to be appropriately managed in patients with specific conditions." @default.
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• W4387344584 date "2023-10-04" @default.
• W4387344584 modified "2023-10-06" @default.
• W4387344584 title "Impact of decreased levels of total CO2 on in-hospital mortality in patients with COVID-19" @default.
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• W4387344584 doi "https://doi.org/10.1038/s41598-023-41988-4" @default.
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