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- W4387345527 endingPage "e20656" @default.
- W4387345527 startingPage "e20656" @default.
- W4387345527 abstract "Cancer cells frequently change their metabolism from aerobic glycolysis to lipid metabolism and amino acid metabolism to adapt to the malignant biological behaviours of infinite proliferation and distant metastasis. The significance of metabolic substances and patterns in tumour cell metastasis is becoming increasingly prominent. Tumour metastasis involves a series of significant steps such as the shedding of cancer cells from a primary tumour, resistance to apoptosis, and colonisation of metastatic sites. However, the role of glutamine in these processes remains unclear. This review summarises the key enzymes and transporters involved in glutamine metabolism that are related to the pathogenesis of malignant tumour metastasis. We also list the roles of glutamine in resisting oxidative stress and promoting immune escape. Finally, the significance of targeting glutamine metabolism in inhibiting tumour metastasis was proposed, research in this field improving our understanding of amino acid metabolism rewiring and simultaneously bringing about new and exciting therapeutic prospects." @default.
- W4387345527 created "2023-10-05" @default.
- W4387345527 creator A5004890734 @default.
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- W4387345527 creator A5075558036 @default.
- W4387345527 creator A5086678682 @default.
- W4387345527 creator A5088610928 @default.
- W4387345527 date "2023-10-01" @default.
- W4387345527 modified "2023-10-15" @default.
- W4387345527 title "Glutamine metabolism in tumor metastasis: Genes, mechanisms and the therapeutic targets" @default.
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