FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387345557> ?p ?o ?g. }

• W4387345557 abstract "Abstract Background Embolic stroke of undetermined source (ESUS) accounts for a substantial proportion of ischaemic strokes. A stroke recurrence score has been shown to predict the risk of recurrent stroke in patients with ESUS based on a combination of clinical and imaging features. This study aimed to externally validate the performance of the ESUS recurrence score using data from a randomized controlled trial. Methods The validation dataset consisted of eligible stroke patients with available magnetic resonance imaging (MRI) data enrolled in the PreDAFIS sub-study of the MonDAFIS study. The score was calculated using three variables: age (1 point per decade after 35 years), presence of white matter hyperintensities (2 points), and multiterritorial ischaemic stroke (3 points). Patients were assigned to risk groups as described in the original publication. The model was evaluated using standard discrimination and calibration methods. Results Of the 1054 patients, 241 (22.9%) were classified as ESUS. Owing to insufficient MRI quality, three patients were excluded, leaving 238 patients (median age 65.5 years [IQR 20.75], 39% female) for analysis. Of these, 30 (13%) patients experienced recurrent ischaemic stroke or transient ischemic attack (TIA) during a follow-up period of 383 patient-years, corresponding to an incidence rate of 7.8 per 100 patient-years (95% CI 5.3–11.2). Patients with an ESUS recurrence score value of ≥ 7 had a 2.46 (hazard ratio (HR), 95% CI 1.02–5.93) times higher risk of stroke recurrence than patients with a score of 0–4. The cumulative probability of stroke recurrence in the low-(0–4), intermediate-(5–6), and high-risk group (≥ 7) was 9%, 13%, and 23%, respectively (log-rank test, χ 2 = 4.2, p = 0.1). Conclusions This external validation of a published scoring system supports a threshold of ≥ 7 for identifying ESUS patients at high-risk of stroke recurrence. However, further adjustments may be required to improve the model’s performance in independent cohorts. The use of risk scores may be helpful in guiding extended diagnostics and further trials on secondary prevention in patients with ESUS. Trial registration: Clinical Trials, NCT02204267. Registered 30 July 2014, https://clinicaltrials.gov/ct2/show/NCT02204267 ." @default.
• W4387345557 created "2023-10-05" @default.
• W4387345557 creator A5001101402 @default.
• W4387345557 creator A5006938674 @default.
• W4387345557 creator A5008903735 @default.
• W4387345557 creator A5012305234 @default.
• W4387345557 creator A5012780516 @default.
• W4387345557 creator A5013144930 @default.
• W4387345557 creator A5025865872 @default.
• W4387345557 creator A5034524811 @default.
• W4387345557 creator A5039490283 @default.
• W4387345557 creator A5047325459 @default.
• W4387345557 creator A5050816239 @default.
• W4387345557 creator A5060503236 @default.
• W4387345557 creator A5073470250 @default.
• W4387345557 creator A5076026606 @default.
• W4387345557 creator A5083465466 @default.
• W4387345557 date "2023-10-05" @default.
• W4387345557 modified "2023-10-07" @default.
• W4387345557 title "Independent external validation of a stroke recurrence score in patients with embolic stroke of undetermined source" @default.
• W4387345557 cites W1752678850 @default.
• W4387345557 cites W1985299015 @default.
• W4387345557 cites W2018195004 @default.
• W4387345557 cites W2084164487 @default.
• W4387345557 cites W2091931051 @default.
• W4387345557 cites W2115709314 @default.
• W4387345557 cites W2116427214 @default.
• W4387345557 cites W2162586165 @default.
• W4387345557 cites W2591708623 @default.
• W4387345557 cites W2803966697 @default.
• W4387345557 cites W2912139642 @default.
• W4387345557 cites W2926850141 @default.
• W4387345557 cites W2945825099 @default.
• W4387345557 cites W2949561150 @default.
• W4387345557 cites W2966007257 @default.
• W4387345557 cites W2981651253 @default.
• W4387345557 cites W2982460763 @default.
• W4387345557 cites W3014391957 @default.
• W4387345557 cites W3017230206 @default.
• W4387345557 cites W3025201546 @default.
• W4387345557 cites W3082188176 @default.
• W4387345557 cites W3109609494 @default.
• W4387345557 cites W3163274412 @default.
• W4387345557 cites W3209562018 @default.
• W4387345557 cites W4229015896 @default.
• W4387345557 cites W4229444410 @default.
• W4387345557 cites W4281489573 @default.
• W4387345557 doi "https://doi.org/10.1186/s42466-023-00279-z" @default.
• W4387345557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37794453" @default.
• W4387345557 hasPublicationYear "2023" @default.
• W4387345557 type Work @default.
• W4387345557 citedByCount "0" @default.
• W4387345557 crossrefType "journal-article" @default.
• W4387345557 hasAuthorship W4387345557A5001101402 @default.
• W4387345557 hasAuthorship W4387345557A5006938674 @default.
• W4387345557 hasAuthorship W4387345557A5008903735 @default.
• W4387345557 hasAuthorship W4387345557A5012305234 @default.
• W4387345557 hasAuthorship W4387345557A5012780516 @default.
• W4387345557 hasAuthorship W4387345557A5013144930 @default.
• W4387345557 hasAuthorship W4387345557A5025865872 @default.
• W4387345557 hasAuthorship W4387345557A5034524811 @default.
• W4387345557 hasAuthorship W4387345557A5039490283 @default.
• W4387345557 hasAuthorship W4387345557A5047325459 @default.
• W4387345557 hasAuthorship W4387345557A5050816239 @default.
• W4387345557 hasAuthorship W4387345557A5060503236 @default.
• W4387345557 hasAuthorship W4387345557A5073470250 @default.
• W4387345557 hasAuthorship W4387345557A5076026606 @default.
• W4387345557 hasAuthorship W4387345557A5083465466 @default.
• W4387345557 hasBestOaLocation W43873455571 @default.
• W4387345557 hasConcept C120665830 @default.
• W4387345557 hasConcept C121332964 @default.
• W4387345557 hasConcept C126322002 @default.
• W4387345557 hasConcept C126838900 @default.
• W4387345557 hasConcept C127413603 @default.
• W4387345557 hasConcept C143409427 @default.
• W4387345557 hasConcept C146638467 @default.
• W4387345557 hasConcept C164705383 @default.
• W4387345557 hasConcept C168563851 @default.
• W4387345557 hasConcept C207103383 @default.
• W4387345557 hasConcept C2780645631 @default.
• W4387345557 hasConcept C2910003425 @default.
• W4387345557 hasConcept C3020199598 @default.
• W4387345557 hasConcept C44249647 @default.
• W4387345557 hasConcept C541997718 @default.
• W4387345557 hasConcept C61511704 @default.
• W4387345557 hasConcept C71924100 @default.
• W4387345557 hasConcept C78519656 @default.
• W4387345557 hasConceptScore W4387345557C120665830 @default.
• W4387345557 hasConceptScore W4387345557C121332964 @default.
• W4387345557 hasConceptScore W4387345557C126322002 @default.
• W4387345557 hasConceptScore W4387345557C126838900 @default.
• W4387345557 hasConceptScore W4387345557C127413603 @default.
• W4387345557 hasConceptScore W4387345557C143409427 @default.
• W4387345557 hasConceptScore W4387345557C146638467 @default.
• W4387345557 hasConceptScore W4387345557C164705383 @default.
• W4387345557 hasConceptScore W4387345557C168563851 @default.
• W4387345557 hasConceptScore W4387345557C207103383 @default.
• W4387345557 hasConceptScore W4387345557C2780645631 @default.
• W4387345557 hasConceptScore W4387345557C2910003425 @default.
• W4387345557 hasConceptScore W4387345557C3020199598 @default.

• next