Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387345559> ?p ?o ?g. }
- W4387345559 endingPage "123485" @default.
- W4387345559 startingPage "123485" @default.
- W4387345559 abstract "Electrochemotherapy (ECT) involves combining anticancer drugs with electroporation, which is induced by pulsed electric fields (PEFs), while the effects vary in effectiveness based on the specific parameters of the electrical pulses and susceptibility of the cells to a specific drug. In this work, we utilized conventional microsecond electroporation protocols (0.8 - 1.5 kV/cm × 100 μs × 8, 1 Hz) and the new modality of nanosecond pulses (4 and 8 kV/cm × 500 ns × 100, 1 kHz and 1 MHz), which are compressed into a high frequency burst. Sensitive and resistant lung, breast and ovarian human cancer cell lines were used in the study. In order to overcome drug-resistance, we have investigated the feasibility to use anticancer drug cocktails i.e., bleomycin and cisplatin combinations with metformin, vinorelbine and Dp44mT. The different susceptibility of various human cancer cells lines to electric pulses was determined, the efficacy of ECT was characterized and the type of cell death depending on the combinations of drugs was investigated. The results indicate that synergistic effects of PEFs with drug cocktails may be used to overcome drug-resistance in cancer, while the application of nsPEF provides more flexibility in parametric protocols and modulation of cancer cell death." @default.
- W4387345559 created "2023-10-05" @default.
- W4387345559 creator A5008935240 @default.
- W4387345559 creator A5038367982 @default.
- W4387345559 creator A5056004786 @default.
- W4387345559 creator A5060992227 @default.
- W4387345559 creator A5068005766 @default.
- W4387345559 creator A5090581148 @default.
- W4387345559 date "2023-11-01" @default.
- W4387345559 modified "2023-10-15" @default.
- W4387345559 title "Susceptibility of Various Human Cancer Cell Lines to Nanosecond and Microsecond Range Electrochemotherapy: Feasibility of Multi-drug Cocktails" @default.
- W4387345559 cites W1490324405 @default.
- W4387345559 cites W1902180775 @default.
- W4387345559 cites W2016406973 @default.
- W4387345559 cites W2036440806 @default.
- W4387345559 cites W2053881449 @default.
- W4387345559 cites W2053977619 @default.
- W4387345559 cites W2056221094 @default.
- W4387345559 cites W2057191563 @default.
- W4387345559 cites W2061061337 @default.
- W4387345559 cites W2080982544 @default.
- W4387345559 cites W2098851488 @default.
- W4387345559 cites W2114144028 @default.
- W4387345559 cites W2122698968 @default.
- W4387345559 cites W2123124795 @default.
- W4387345559 cites W2141606387 @default.
- W4387345559 cites W2153394592 @default.
- W4387345559 cites W2162071711 @default.
- W4387345559 cites W2167670081 @default.
- W4387345559 cites W2169652500 @default.
- W4387345559 cites W2301869921 @default.
- W4387345559 cites W2412417578 @default.
- W4387345559 cites W2489688011 @default.
- W4387345559 cites W2566109146 @default.
- W4387345559 cites W2591544982 @default.
- W4387345559 cites W2618992091 @default.
- W4387345559 cites W2737638436 @default.
- W4387345559 cites W2791209983 @default.
- W4387345559 cites W2883795059 @default.
- W4387345559 cites W3003142605 @default.
- W4387345559 cites W3012838993 @default.
- W4387345559 cites W3016345086 @default.
- W4387345559 cites W3040625082 @default.
- W4387345559 cites W3045665684 @default.
- W4387345559 cites W3082139497 @default.
- W4387345559 cites W3092260859 @default.
- W4387345559 cites W3092327093 @default.
- W4387345559 cites W3133772522 @default.
- W4387345559 cites W3156628922 @default.
- W4387345559 cites W3164080050 @default.
- W4387345559 cites W3164737800 @default.
- W4387345559 cites W3192007527 @default.
- W4387345559 cites W3205877872 @default.
- W4387345559 cites W4225683993 @default.
- W4387345559 cites W4229056544 @default.
- W4387345559 cites W4293733506 @default.
- W4387345559 cites W4312085116 @default.
- W4387345559 cites W4312140611 @default.
- W4387345559 cites W4313500570 @default.
- W4387345559 cites W4316363269 @default.
- W4387345559 cites W4321598806 @default.
- W4387345559 doi "https://doi.org/10.1016/j.ijpharm.2023.123485" @default.
- W4387345559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37802257" @default.
- W4387345559 hasPublicationYear "2023" @default.
- W4387345559 type Work @default.
- W4387345559 citedByCount "0" @default.
- W4387345559 crossrefType "journal-article" @default.
- W4387345559 hasAuthorship W4387345559A5008935240 @default.
- W4387345559 hasAuthorship W4387345559A5038367982 @default.
- W4387345559 hasAuthorship W4387345559A5056004786 @default.
- W4387345559 hasAuthorship W4387345559A5060992227 @default.
- W4387345559 hasAuthorship W4387345559A5068005766 @default.
- W4387345559 hasAuthorship W4387345559A5090581148 @default.
- W4387345559 hasBestOaLocation W43873455591 @default.
- W4387345559 hasConcept C104317684 @default.
- W4387345559 hasConcept C121332964 @default.
- W4387345559 hasConcept C121608353 @default.
- W4387345559 hasConcept C126322002 @default.
- W4387345559 hasConcept C1276947 @default.
- W4387345559 hasConcept C136229726 @default.
- W4387345559 hasConcept C185592680 @default.
- W4387345559 hasConcept C186852380 @default.
- W4387345559 hasConcept C192562407 @default.
- W4387345559 hasConcept C2776232574 @default.
- W4387345559 hasConcept C2776694085 @default.
- W4387345559 hasConcept C2777108052 @default.
- W4387345559 hasConcept C2778239845 @default.
- W4387345559 hasConcept C2780035454 @default.
- W4387345559 hasConcept C34742353 @default.
- W4387345559 hasConcept C55493867 @default.
- W4387345559 hasConcept C71924100 @default.
- W4387345559 hasConcept C96232424 @default.
- W4387345559 hasConcept C98274493 @default.
- W4387345559 hasConceptScore W4387345559C104317684 @default.
- W4387345559 hasConceptScore W4387345559C121332964 @default.
- W4387345559 hasConceptScore W4387345559C121608353 @default.
- W4387345559 hasConceptScore W4387345559C126322002 @default.
- W4387345559 hasConceptScore W4387345559C1276947 @default.