Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387345807> ?p ?o ?g. }
- W4387345807 endingPage "108070" @default.
- W4387345807 startingPage "108070" @default.
- W4387345807 abstract "Plant species have evolved diverse metabolic pathways to effectively respond to internal and external signals throughout their life cycle, allowing adaptation to their sessile and phototropic nature. These pathways selectively activate specific metabolic processes, producing plant secondary metabolites (PSMs) governed by genetic and environmental factors. Humans have utilized PSM-enriched plant sources for millennia in medicine and nutraceuticals. Recent technological advances have significantly contributed to discovering metabolic pathways and related genes involved in the biosynthesis of specific PSM in different food crops and medicinal plants. Consequently, there is a growing demand for plant materials rich in nutrients and bioactive compounds, marketed as “superfoods”. To meet the industrial demand for superfoods and therapeutic PSMs, modern methods such as system biology, omics, synthetic biology, and genome editing (GE) play a crucial role in identifying the molecular players, limiting steps, and regulatory circuitry involved in PSM production. Among these methods, clustered regularly interspaced short palindromic repeats-CRISPR associated protein (CRISPR/Cas) is the most widely used system for plant GE due to its simple design, flexibility, precision, and multiplexing capabilities. Utilizing the CRISPR-based toolbox for metabolic engineering (ME) offers an ideal solution for developing plants with tailored preventive (nutraceuticals) and curative (therapeutic) metabolic profiles in an ecofriendly way. This review discusses recent advances in understanding the multifactorial regulation of metabolic pathways, the application of CRISPR-based tools for plant ME, and the potential research areas for enhancing plant metabolic profiles." @default.
- W4387345807 created "2023-10-05" @default.
- W4387345807 creator A5016092022 @default.
- W4387345807 creator A5016496098 @default.
- W4387345807 creator A5046670877 @default.
- W4387345807 creator A5074033206 @default.
- W4387345807 date "2023-10-01" @default.
- W4387345807 modified "2023-10-12" @default.
- W4387345807 title "Unlocking secrets of nature's chemists: Potential of CRISPR/Cas-based tools in plant metabolic engineering for customized nutraceutical and medicinal profiles" @default.
- W4387345807 cites W1487878063 @default.
- W4387345807 cites W1830282417 @default.
- W4387345807 cites W1971430242 @default.
- W4387345807 cites W1990226486 @default.
- W4387345807 cites W1990331986 @default.
- W4387345807 cites W1992740755 @default.
- W4387345807 cites W2004037988 @default.
- W4387345807 cites W2018908972 @default.
- W4387345807 cites W2019727923 @default.
- W4387345807 cites W2045435533 @default.
- W4387345807 cites W2059041677 @default.
- W4387345807 cites W2067041321 @default.
- W4387345807 cites W2071654564 @default.
- W4387345807 cites W2072369409 @default.
- W4387345807 cites W2076239411 @default.
- W4387345807 cites W2085587146 @default.
- W4387345807 cites W2091981172 @default.
- W4387345807 cites W2097693284 @default.
- W4387345807 cites W2098390695 @default.
- W4387345807 cites W2099236544 @default.
- W4387345807 cites W2103292533 @default.
- W4387345807 cites W2120381562 @default.
- W4387345807 cites W2145484725 @default.
- W4387345807 cites W2149058703 @default.
- W4387345807 cites W2149202606 @default.
- W4387345807 cites W2151943426 @default.
- W4387345807 cites W2168059482 @default.
- W4387345807 cites W2344104081 @default.
- W4387345807 cites W2346346359 @default.
- W4387345807 cites W2444500095 @default.
- W4387345807 cites W2466338408 @default.
- W4387345807 cites W2466635249 @default.
- W4387345807 cites W2470595052 @default.
- W4387345807 cites W2502088148 @default.
- W4387345807 cites W2516007520 @default.
- W4387345807 cites W2534942962 @default.
- W4387345807 cites W2549065004 @default.
- W4387345807 cites W2549285722 @default.
- W4387345807 cites W2550084063 @default.
- W4387345807 cites W2556041259 @default.
- W4387345807 cites W2559713102 @default.
- W4387345807 cites W2563084198 @default.
- W4387345807 cites W2573251321 @default.
- W4387345807 cites W2589515024 @default.
- W4387345807 cites W2592302293 @default.
- W4387345807 cites W2600356541 @default.
- W4387345807 cites W2607239001 @default.
- W4387345807 cites W2610308012 @default.
- W4387345807 cites W2611126110 @default.
- W4387345807 cites W2617803937 @default.
- W4387345807 cites W2673137008 @default.
- W4387345807 cites W2727409292 @default.
- W4387345807 cites W2738219005 @default.
- W4387345807 cites W2741798010 @default.
- W4387345807 cites W2746449753 @default.
- W4387345807 cites W2748023196 @default.
- W4387345807 cites W2756004972 @default.
- W4387345807 cites W2766581318 @default.
- W4387345807 cites W2767852758 @default.
- W4387345807 cites W2772111819 @default.
- W4387345807 cites W2772933620 @default.
- W4387345807 cites W2773816027 @default.
- W4387345807 cites W2782726512 @default.
- W4387345807 cites W2783749221 @default.
- W4387345807 cites W2788571669 @default.
- W4387345807 cites W2788814921 @default.
- W4387345807 cites W2791966247 @default.
- W4387345807 cites W2792053361 @default.
- W4387345807 cites W2800359811 @default.
- W4387345807 cites W2801167893 @default.
- W4387345807 cites W2801183490 @default.
- W4387345807 cites W2801317575 @default.
- W4387345807 cites W2801363769 @default.
- W4387345807 cites W2802107954 @default.
- W4387345807 cites W2802210059 @default.
- W4387345807 cites W2802711206 @default.
- W4387345807 cites W2803454767 @default.
- W4387345807 cites W2803937731 @default.
- W4387345807 cites W2809114249 @default.
- W4387345807 cites W2810726554 @default.
- W4387345807 cites W2810906404 @default.
- W4387345807 cites W2842718607 @default.
- W4387345807 cites W2884515841 @default.
- W4387345807 cites W2886810956 @default.
- W4387345807 cites W2891495337 @default.
- W4387345807 cites W2892968638 @default.
- W4387345807 cites W2894252291 @default.
- W4387345807 cites W2896903991 @default.
- W4387345807 cites W2897406288 @default.