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• W4387352977 abstract "Second-line therapy for advanced non−small cell lung cancer (NSCLC) has undergone several major shifts in the past 10 years, evolving along with the therapeutic progress seen in the first-line setting. The introduction of immunotherapy, specifically anti-PD-1 (programmed death 1)/PD-L1 (programmed death ligand 1) therapies, into the second-line setting represented the first significant improvement in clinical outcomes for patients receiving second-line therapy for advanced NSCLC in decades, with superiority in both efficacy and tolerability compared with prior standard of care cytotoxic chemotherapy. However, now that anti-PD-1/PD-L1 therapies have moved into the first-line setting, selection of second-line therapy after disease progression on first-line immunotherapy-containing regimens has become a crucial clinical question for which data to guide management are only starting to emerge. We review here the evidence base for the use of immunotherapy in immunotherapy-naïve patients and second-line docetaxel-based regimens. We discuss emerging data on management strategies and outcomes for patients who have disease progression on or after first-line immunotherapy-containing regimens, including whether there could be changes in the efficacy of cytotoxic chemotherapy in the postimmunotherapy setting, immunotherapy retreatment, and emerging combination immunotherapy strategies in clinical trials in the postimmunotherapy progression setting." @default.
• W4387352977 created "2023-10-05" @default.
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• W4387352977 date "2024-01-01" @default.
• W4387352977 modified "2023-10-06" @default.
• W4387352977 title "Second-line therapy in advanced non–small cell lung cancer" @default.
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• W4387352977 doi "https://doi.org/10.1016/b978-0-323-69573-2.00018-8" @default.
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