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- W4387353004 abstract "Small cell lung cancer is a highly lethal subtype of lung cancer, characterized by early dissemination and poor survival. Classically, it arises centrally and often presents with symptoms related to local obstruction of airways or blood vessels. When detected at a relatively early stage, definitive thoracic radiation coupled with platinum-based chemotherapy offers high response rates, but long-term survival will be achieved only by a small minority of patients. Most patients present with advanced disease at diagnosis. In the advanced or relapsed setting, systemic chemotherapy has been the standard of care for decades. Response rates are high but progression free, and overall survival are limited. The standard of care was stagnant for many years, but recent advances in immunotherapy have led to better outcomes. The addition of the checkpoint inhibitor atezolizumab to standard chemotherapy led to a significant improvement in overall survival, the first intervention to do so in decades. A subsequent trial demonstrated similar improvement with the addition of durvalumab to chemotherapy. While combination chemotherapy plus immunotherapy has established a new standard of care, survival is poor for most patients and more effective treatment strategies remain an unmet need." @default.
- W4387353004 created "2023-10-05" @default.
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- W4387353004 date "2024-01-01" @default.
- W4387353004 modified "2023-10-06" @default.
- W4387353004 title "Small cell lung cancer" @default.
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- W4387353004 doi "https://doi.org/10.1016/b978-0-323-69573-2.00023-1" @default.
- W4387353004 hasPublicationYear "2024" @default.
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