FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387354329> ?p ?o ?g. }

• W4387354329 abstract "Irinotecan (IRI), an anticancer drug to treat colon cancer patients, causes cytotoxic effects on normal cells. Phenethyl isothiocyanate (PEITC), rich in common cruciferous plants, has anticancer activities (induction of cell apoptosis) in many human cancer cells, including colon cancer cells. However, the anticancer effects of IRI combined with PEITC on human colon cancer cells in vitro were unavailable. Herein, the aim of this study is to focus on the apoptotic effects of the combination of IRI and PEITC on human colon cancer HCT 116 cells in vitro. Propidium iodide (PI) exclusion and Annexin V/PI staining assays showed that IRI combined with PEITC decreased viable cell number and induced higher cell apoptosis than that of IRI or PEITC only in HCT 116 cells. Moreover, combined treatment induced higher levels of reactive oxygen species (ROS) and Ca2+ than that of IRI or PEITC only. Cells pre-treated with N-acetyl-l-cysteine (scavenger of ROS) and then treated with IRI, PEITC, or IRI combined with PEITC showed increased viable cell numbers than that of IRI or PEITC only. IRI combined with PEITC increased higher caspase-3, -8, and -9 activities than that of IRI or PEITC only by flow cytometer assay. IRI combined with PEITC induced higher levels of ER stress-, mitochondria-, and caspase-associated proteins than that of IRI or PEITC treatment only in HCT 116 cells. Based on these observations, PEITC potentiates IRI anticancer activity by promoting cell apoptosis in the human colon HCT 116 cells. Thus, PEITC may be a potential enhancer for IRI in humans as an anticolon cancer drug in the future." @default.
• W4387354329 created "2023-10-05" @default.
• W4387354329 creator A5015238792 @default.
• W4387354329 creator A5017303641 @default.
• W4387354329 creator A5028423755 @default.
• W4387354329 creator A5037534327 @default.
• W4387354329 creator A5042244659 @default.
• W4387354329 creator A5052730965 @default.
• W4387354329 creator A5060676824 @default.
• W4387354329 creator A5077539337 @default.
• W4387354329 date "2023-10-04" @default.
• W4387354329 modified "2023-10-06" @default.
• W4387354329 title "Phenethyl isothiocyanate and irinotecan synergistically induce cell apoptosis in colon cancer <scp>HCT</scp> 116 cells in vitro" @default.
• W4387354329 cites W1585383225 @default.
• W4387354329 cites W1995087167 @default.
• W4387354329 cites W1997656886 @default.
• W4387354329 cites W2001656004 @default.
• W4387354329 cites W2048189382 @default.
• W4387354329 cites W2071289888 @default.
• W4387354329 cites W2080901528 @default.
• W4387354329 cites W2085597352 @default.
• W4387354329 cites W2090753175 @default.
• W4387354329 cites W2092759765 @default.
• W4387354329 cites W2095215050 @default.
• W4387354329 cites W2098160574 @default.
• W4387354329 cites W2121569914 @default.
• W4387354329 cites W2125570177 @default.
• W4387354329 cites W2135940820 @default.
• W4387354329 cites W2139002359 @default.
• W4387354329 cites W2139695381 @default.
• W4387354329 cites W2163956097 @default.
• W4387354329 cites W2239981289 @default.
• W4387354329 cites W2252711380 @default.
• W4387354329 cites W2294419491 @default.
• W4387354329 cites W2296733663 @default.
• W4387354329 cites W2314927739 @default.
• W4387354329 cites W2332494992 @default.
• W4387354329 cites W2337971259 @default.
• W4387354329 cites W2409136177 @default.
• W4387354329 cites W2518980791 @default.
• W4387354329 cites W2531421656 @default.
• W4387354329 cites W2600452401 @default.
• W4387354329 cites W2604490519 @default.
• W4387354329 cites W2626529720 @default.
• W4387354329 cites W2755112369 @default.
• W4387354329 cites W2773268832 @default.
• W4387354329 cites W2785091318 @default.
• W4387354329 cites W2790222074 @default.
• W4387354329 cites W2793987623 @default.
• W4387354329 cites W2800367160 @default.
• W4387354329 cites W2834358214 @default.
• W4387354329 cites W2890271077 @default.
• W4387354329 cites W2901712937 @default.
• W4387354329 cites W2944523360 @default.
• W4387354329 cites W2952410122 @default.
• W4387354329 cites W2983567059 @default.
• W4387354329 cites W3009963727 @default.
• W4387354329 cites W3014723835 @default.
• W4387354329 cites W3036760063 @default.
• W4387354329 cites W3086143703 @default.
• W4387354329 cites W3130224122 @default.
• W4387354329 cites W4210741433 @default.
• W4387354329 cites W4214869304 @default.
• W4387354329 cites W4232250733 @default.
• W4387354329 cites W4255402093 @default.
• W4387354329 cites W4282834621 @default.
• W4387354329 cites W4307721635 @default.
• W4387354329 cites W4321607727 @default.
• W4387354329 cites W4322719806 @default.
• W4387354329 cites W4361006837 @default.
• W4387354329 doi "https://doi.org/10.1002/tox.23993" @default.
• W4387354329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37792803" @default.
• W4387354329 hasPublicationYear "2023" @default.
• W4387354329 type Work @default.
• W4387354329 citedByCount "0" @default.
• W4387354329 crossrefType "journal-article" @default.
• W4387354329 hasAuthorship W4387354329A5015238792 @default.
• W4387354329 hasAuthorship W4387354329A5017303641 @default.
• W4387354329 hasAuthorship W4387354329A5028423755 @default.
• W4387354329 hasAuthorship W4387354329A5037534327 @default.
• W4387354329 hasAuthorship W4387354329A5042244659 @default.
• W4387354329 hasAuthorship W4387354329A5052730965 @default.
• W4387354329 hasAuthorship W4387354329A5060676824 @default.
• W4387354329 hasAuthorship W4387354329A5077539337 @default.
• W4387354329 hasConcept C121608353 @default.
• W4387354329 hasConcept C126322002 @default.
• W4387354329 hasConcept C185592680 @default.
• W4387354329 hasConcept C190283241 @default.
• W4387354329 hasConcept C2775934118 @default.
• W4387354329 hasConcept C2780740852 @default.
• W4387354329 hasConcept C31573885 @default.
• W4387354329 hasConcept C502942594 @default.
• W4387354329 hasConcept C55493867 @default.
• W4387354329 hasConcept C71924100 @default.
• W4387354329 hasConcept C86803240 @default.
• W4387354329 hasConcept C96232424 @default.
• W4387354329 hasConcept C98274493 @default.
• W4387354329 hasConceptScore W4387354329C121608353 @default.
• W4387354329 hasConceptScore W4387354329C126322002 @default.
• W4387354329 hasConceptScore W4387354329C185592680 @default.

• next