FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387356795> ?p ?o ?g. }

• W4387356795 abstract "Abstract Anxiety manifestations and cognitive dysfunction are common sequelae in patients with sepsis-associated encephalopathy (SAE). Microglia-mediated inflammatory signaling is involved in anxiety, depression, and cognitive dysfunction during acute infection with bacterial lipopolysaccharide (LPS). However, the molecular mechanisms underlying microglia activation and behavioral and cognitive deficits in sepsis have not been in fully elucidated. Based on previous research, we speculated that the CD137 receptor/ligand system modulates microglia function during sepsis to mediate classical neurological SAE symptoms. A murine model of SAE was established by injecting male C57BL/6 mice with LPS, and cultured mouse BV2 microglia were used for in vitro assays. RT-qPCR, immunofluorescence staining, flow cytometry, and ELISA were used to assess microglial activation and the expression of CD137L and inflammation-related cytokines in the mouse hippocampus and in cultured BV2 cells. In addition, behavioral tests were conducted in assess cognitive performance and behavioral distress. Immunofluorescence and RT-qPCR analyses showed that hippocampal expression of CD137L was upregulated in activated microglia following LPS treatment. Pre-treatment with the CD137L neutralizing antibody TKS-1 significantly reduced CD137L levels, attenuated the expression of M1 polarization markers in microglia, and inhibited the production of TNF-α, IL-1β, and IL-6 in both LPS-treated mice and BV2 cells. Conversely, stimulation of CD137L signaling by recombinant CD137-Fc fusion protein activated the synthesis and release of pro-inflammatory cytokines in cultures BV2 microglia. Importantly, open field, elevated plus maze, and Y-maze spontaneous alternation test results indicated that TKS-1 administration alleviated anxiety-like behavior and spatial memory decline in mice with LPS-induced SAE. These findings suggest that CD137L upregulation in activated microglia critically contributes to neuroinflammation, anxiety-like behavior, and cognitive dysfunction in the mouse model of LPS-induced sepsis. Therefore, therapeutic modulation of the CD137L/CD137 signaling pathway may represent an effective way to minimize brain damage and prevent cognitive and emotional deficits associated with SAE." @default.
• W4387356795 created "2023-10-06" @default.
• W4387356795 creator A5007275423 @default.
• W4387356795 creator A5011848072 @default.
• W4387356795 creator A5016873310 @default.
• W4387356795 creator A5021404248 @default.
• W4387356795 creator A5024192388 @default.
• W4387356795 creator A5031617363 @default.
• W4387356795 creator A5032378268 @default.
• W4387356795 creator A5035948526 @default.
• W4387356795 creator A5047806168 @default.
• W4387356795 creator A5048366988 @default.
• W4387356795 creator A5063953679 @default.
• W4387356795 creator A5073898129 @default.
• W4387356795 creator A5074622138 @default.
• W4387356795 creator A5085762574 @default.
• W4387356795 date "2023-10-05" @default.
• W4387356795 modified "2023-10-06" @default.
• W4387356795 title "CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy" @default.
• W4387356795 cites W1972850922 @default.
• W4387356795 cites W2029582308 @default.
• W4387356795 cites W2047526240 @default.
• W4387356795 cites W2048359313 @default.
• W4387356795 cites W2072110051 @default.
• W4387356795 cites W2076279535 @default.
• W4387356795 cites W2079454790 @default.
• W4387356795 cites W2101898118 @default.
• W4387356795 cites W2113794824 @default.
• W4387356795 cites W2127723018 @default.
• W4387356795 cites W2142943268 @default.
• W4387356795 cites W2146763135 @default.
• W4387356795 cites W2147180300 @default.
• W4387356795 cites W2154787260 @default.
• W4387356795 cites W2156666186 @default.
• W4387356795 cites W2164481426 @default.
• W4387356795 cites W2164963610 @default.
• W4387356795 cites W2172172243 @default.
• W4387356795 cites W2280404143 @default.
• W4387356795 cites W2288805393 @default.
• W4387356795 cites W2744745622 @default.
• W4387356795 cites W2782831937 @default.
• W4387356795 cites W2792447503 @default.
• W4387356795 cites W2793723979 @default.
• W4387356795 cites W2803039969 @default.
• W4387356795 cites W2891403276 @default.
• W4387356795 cites W2898837291 @default.
• W4387356795 cites W2955187387 @default.
• W4387356795 cites W2960015172 @default.
• W4387356795 cites W2972223532 @default.
• W4387356795 cites W3004285897 @default.
• W4387356795 cites W3033538054 @default.
• W4387356795 cites W3036684707 @default.
• W4387356795 cites W3039965632 @default.
• W4387356795 cites W3040585898 @default.
• W4387356795 cites W3107206669 @default.
• W4387356795 cites W3162998211 @default.
• W4387356795 cites W3163689842 @default.
• W4387356795 cites W3180853779 @default.
• W4387356795 cites W3214216551 @default.
• W4387356795 cites W4206215079 @default.
• W4387356795 cites W4229023093 @default.
• W4387356795 cites W4282945568 @default.
• W4387356795 cites W4310463872 @default.
• W4387356795 doi "https://doi.org/10.1007/s12017-023-08764-z" @default.
• W4387356795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37796401" @default.
• W4387356795 hasPublicationYear "2023" @default.
• W4387356795 type Work @default.
• W4387356795 citedByCount "0" @default.
• W4387356795 crossrefType "journal-article" @default.
• W4387356795 hasAuthorship W4387356795A5007275423 @default.
• W4387356795 hasAuthorship W4387356795A5011848072 @default.
• W4387356795 hasAuthorship W4387356795A5016873310 @default.
• W4387356795 hasAuthorship W4387356795A5021404248 @default.
• W4387356795 hasAuthorship W4387356795A5024192388 @default.
• W4387356795 hasAuthorship W4387356795A5031617363 @default.
• W4387356795 hasAuthorship W4387356795A5032378268 @default.
• W4387356795 hasAuthorship W4387356795A5035948526 @default.
• W4387356795 hasAuthorship W4387356795A5047806168 @default.
• W4387356795 hasAuthorship W4387356795A5048366988 @default.
• W4387356795 hasAuthorship W4387356795A5063953679 @default.
• W4387356795 hasAuthorship W4387356795A5073898129 @default.
• W4387356795 hasAuthorship W4387356795A5074622138 @default.
• W4387356795 hasAuthorship W4387356795A5085762574 @default.
• W4387356795 hasBestOaLocation W43873567951 @default.
• W4387356795 hasConcept C138906646 @default.
• W4387356795 hasConcept C203014093 @default.
• W4387356795 hasConcept C2776914184 @default.
• W4387356795 hasConcept C2778690821 @default.
• W4387356795 hasConcept C2779830541 @default.
• W4387356795 hasConcept C71924100 @default.
• W4387356795 hasConcept C87753298 @default.
• W4387356795 hasConceptScore W4387356795C138906646 @default.
• W4387356795 hasConceptScore W4387356795C203014093 @default.
• W4387356795 hasConceptScore W4387356795C2776914184 @default.
• W4387356795 hasConceptScore W4387356795C2778690821 @default.
• W4387356795 hasConceptScore W4387356795C2779830541 @default.
• W4387356795 hasConceptScore W4387356795C71924100 @default.
• W4387356795 hasConceptScore W4387356795C87753298 @default.
• W4387356795 hasFunder F4320321001 @default.
• W4387356795 hasFunder F4320321543 @default.

• next