Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387356873> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4387356873 abstract "Autotaxin, encoded by the Enpp2 gene, is an exoenzyme that produces lysophosphatidic acid, thereby regulating many biologic functions. We previously reported that Enpp2 mRNA was abundantly expressed in yolk sac visceral endoderm (VE) cells and that Enpp2−/− mice were lethal at embryonic day 9.5 owing to angiogenic defects in the yolk sac. Enpp2−/− mice showed lysosome fragmentation in VE cells and embryonic abnormalities including allantois malformation, neural tube defects, no axial turning, and head cavity formation. However, whether the defects in endocytic vesicle formation affect membrane trafficking in VE cells remained to be directly examined. In this study, we found that pinocytosis, transcytosis, and secretion of angiogenic factors such as vascular endothelial growth factor and transforming growth factor β1 were impaired in Enpp2−/− VE cells. Moreover, pharmacologic inhibition of membrane trafficking phenocopied the defects of Enpp2−/− mice. These findings demonstrate that Enpp2 spromotes endocytosis and secretion of angiogenic factors in VE cells, thereby regulating angiogenesis/vasculogenesis and embryonic development." @default.
- W4387356873 created "2023-10-06" @default.
- W4387356873 creator A5067667750 @default.
- W4387356873 creator A5079824102 @default.
- W4387356873 creator A5086823058 @default.
- W4387356873 creator A5087982423 @default.
- W4387356873 creator A5093006195 @default.
- W4387356873 date "2023-10-05" @default.
- W4387356873 modified "2023-10-06" @default.
- W4387356873 title "The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells" @default.
- W4387356873 doi "https://doi.org/10.1242/bio.060081" @default.
- W4387356873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37795611" @default.
- W4387356873 hasPublicationYear "2023" @default.
- W4387356873 type Work @default.
- W4387356873 citedByCount "0" @default.
- W4387356873 crossrefType "journal-article" @default.
- W4387356873 hasAuthorship W4387356873A5067667750 @default.
- W4387356873 hasAuthorship W4387356873A5079824102 @default.
- W4387356873 hasAuthorship W4387356873A5086823058 @default.
- W4387356873 hasAuthorship W4387356873A5087982423 @default.
- W4387356873 hasAuthorship W4387356873A5093006195 @default.
- W4387356873 hasBestOaLocation W43873568731 @default.
- W4387356873 hasConcept C104317684 @default.
- W4387356873 hasConcept C126322002 @default.
- W4387356873 hasConcept C134018914 @default.
- W4387356873 hasConcept C145103041 @default.
- W4387356873 hasConcept C167734588 @default.
- W4387356873 hasConcept C170493617 @default.
- W4387356873 hasConcept C196843134 @default.
- W4387356873 hasConcept C2776661833 @default.
- W4387356873 hasConcept C2777025900 @default.
- W4387356873 hasConcept C2777043721 @default.
- W4387356873 hasConcept C2777164004 @default.
- W4387356873 hasConcept C2779094623 @default.
- W4387356873 hasConcept C2780394083 @default.
- W4387356873 hasConcept C37547375 @default.
- W4387356873 hasConcept C502942594 @default.
- W4387356873 hasConcept C55493867 @default.
- W4387356873 hasConcept C71924100 @default.
- W4387356873 hasConcept C86803240 @default.
- W4387356873 hasConcept C95444343 @default.
- W4387356873 hasConceptScore W4387356873C104317684 @default.
- W4387356873 hasConceptScore W4387356873C126322002 @default.
- W4387356873 hasConceptScore W4387356873C134018914 @default.
- W4387356873 hasConceptScore W4387356873C145103041 @default.
- W4387356873 hasConceptScore W4387356873C167734588 @default.
- W4387356873 hasConceptScore W4387356873C170493617 @default.
- W4387356873 hasConceptScore W4387356873C196843134 @default.
- W4387356873 hasConceptScore W4387356873C2776661833 @default.
- W4387356873 hasConceptScore W4387356873C2777025900 @default.
- W4387356873 hasConceptScore W4387356873C2777043721 @default.
- W4387356873 hasConceptScore W4387356873C2777164004 @default.
- W4387356873 hasConceptScore W4387356873C2779094623 @default.
- W4387356873 hasConceptScore W4387356873C2780394083 @default.
- W4387356873 hasConceptScore W4387356873C37547375 @default.
- W4387356873 hasConceptScore W4387356873C502942594 @default.
- W4387356873 hasConceptScore W4387356873C55493867 @default.
- W4387356873 hasConceptScore W4387356873C71924100 @default.
- W4387356873 hasConceptScore W4387356873C86803240 @default.
- W4387356873 hasConceptScore W4387356873C95444343 @default.
- W4387356873 hasFunder F4320309807 @default.
- W4387356873 hasFunder F4320320912 @default.
- W4387356873 hasLocation W43873568731 @default.
- W4387356873 hasLocation W43873568732 @default.
- W4387356873 hasOpenAccess W4387356873 @default.
- W4387356873 hasPrimaryLocation W43873568731 @default.
- W4387356873 hasRelatedWork W1979571079 @default.
- W4387356873 hasRelatedWork W2001801206 @default.
- W4387356873 hasRelatedWork W2054440394 @default.
- W4387356873 hasRelatedWork W2063922243 @default.
- W4387356873 hasRelatedWork W2074528387 @default.
- W4387356873 hasRelatedWork W2130467334 @default.
- W4387356873 hasRelatedWork W2503822754 @default.
- W4387356873 hasRelatedWork W3196768545 @default.
- W4387356873 hasRelatedWork W4282592326 @default.
- W4387356873 hasRelatedWork W4361843582 @default.
- W4387356873 isParatext "false" @default.
- W4387356873 isRetracted "false" @default.
- W4387356873 workType "article" @default.