FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387357061> ?p ?o ?g. }

• W4387357061 abstract "Abstract 5‐Methylcytosine (m 5 C) is a prevalent RNA modification in messenger RNAs (mRNAs). Despite its abundance, its role in the decidua of pre‐eclampsia (PE) remains elusive. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP‐seq) and RNA‐sequencing (RNA‐seq) to map m 5 C peaks and mRNA expression profile in the decidua of human early‐onset PE (EPE), late‐onset PE (LPE), and normal pregnancy (NP). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses elucidated potential roles of the differentially methylated mRNAs (DMGs) and differentially expressed mRNAs in decidualization pathways. Integrative analysis of MeRIP‐seq and RNA‐seq data pinpointed 50 candidate genes linked to PE, marked by both differentially methylated m 5 C peaks and congruent expression changes. To validate these observations, we selected nine genes for verification via quantitative PCR. Our results underscore the precision and reproducibility of our bioinformatics approach. Importantly, we propose that changes in m 5 C modification and expression of relevant mRNA might influence the pathogenesis of PE by hampering decidualization. This work shines light on the distinct mRNA m 5 C modification patterns and expression profiles in the decidua of PE, implicating pivotal signaling disruptions and decidualization impediments in the onset of PE." @default.
• W4387357061 created "2023-10-06" @default.
• W4387357061 creator A5042910869 @default.
• W4387357061 creator A5049712229 @default.
• W4387357061 creator A5050313920 @default.
• W4387357061 date "2023-10-05" @default.
• W4387357061 modified "2023-10-11" @default.
• W4387357061 title "Altered 5‐methylcytosine modification of mRNA is involved in the pathogenesis of pre‐eclampsia" @default.
• W4387357061 cites W1506896046 @default.
• W4387357061 cites W1965186732 @default.
• W4387357061 cites W2036897871 @default.
• W4387357061 cites W2052497884 @default.
• W4387357061 cites W2078964320 @default.
• W4387357061 cites W2085184586 @default.
• W4387357061 cites W2097175728 @default.
• W4387357061 cites W2114104545 @default.
• W4387357061 cites W2119975890 @default.
• W4387357061 cites W2134526812 @default.
• W4387357061 cites W2140048634 @default.
• W4387357061 cites W2171808845 @default.
• W4387357061 cites W2223021721 @default.
• W4387357061 cites W2484335322 @default.
• W4387357061 cites W2606518593 @default.
• W4387357061 cites W2626427494 @default.
• W4387357061 cites W2754876366 @default.
• W4387357061 cites W2793661040 @default.
• W4387357061 cites W2799937252 @default.
• W4387357061 cites W2892333522 @default.
• W4387357061 cites W2911756720 @default.
• W4387357061 cites W2942870687 @default.
• W4387357061 cites W2947506647 @default.
• W4387357061 cites W2955132263 @default.
• W4387357061 cites W2964438344 @default.
• W4387357061 cites W2964888213 @default.
• W4387357061 cites W3015426139 @default.
• W4387357061 cites W301622561 @default.
• W4387357061 cites W3036007662 @default.
• W4387357061 cites W3090821702 @default.
• W4387357061 doi "https://doi.org/10.1002/jcb.30479" @default.
• W4387357061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37796115" @default.
• W4387357061 hasPublicationYear "2023" @default.
• W4387357061 type Work @default.
• W4387357061 citedByCount "0" @default.
• W4387357061 crossrefType "journal-article" @default.
• W4387357061 hasAuthorship W4387357061A5042910869 @default.
• W4387357061 hasAuthorship W4387357061A5049712229 @default.
• W4387357061 hasAuthorship W4387357061A5050313920 @default.
• W4387357061 hasConcept C104317684 @default.
• W4387357061 hasConcept C105580179 @default.
• W4387357061 hasConcept C107397762 @default.
• W4387357061 hasConcept C150194340 @default.
• W4387357061 hasConcept C152724338 @default.
• W4387357061 hasConcept C153911025 @default.
• W4387357061 hasConcept C162317418 @default.
• W4387357061 hasConcept C172680121 @default.
• W4387357061 hasConcept C196843134 @default.
• W4387357061 hasConcept C2776953305 @default.
• W4387357061 hasConcept C2778316770 @default.
• W4387357061 hasConcept C2779234561 @default.
• W4387357061 hasConcept C2780197806 @default.
• W4387357061 hasConcept C41091548 @default.
• W4387357061 hasConcept C54355233 @default.
• W4387357061 hasConcept C67705224 @default.
• W4387357061 hasConcept C86803240 @default.
• W4387357061 hasConcept C95444343 @default.
• W4387357061 hasConceptScore W4387357061C104317684 @default.
• W4387357061 hasConceptScore W4387357061C105580179 @default.
• W4387357061 hasConceptScore W4387357061C107397762 @default.
• W4387357061 hasConceptScore W4387357061C150194340 @default.
• W4387357061 hasConceptScore W4387357061C152724338 @default.
• W4387357061 hasConceptScore W4387357061C153911025 @default.
• W4387357061 hasConceptScore W4387357061C162317418 @default.
• W4387357061 hasConceptScore W4387357061C172680121 @default.
• W4387357061 hasConceptScore W4387357061C196843134 @default.
• W4387357061 hasConceptScore W4387357061C2776953305 @default.
• W4387357061 hasConceptScore W4387357061C2778316770 @default.
• W4387357061 hasConceptScore W4387357061C2779234561 @default.
• W4387357061 hasConceptScore W4387357061C2780197806 @default.
• W4387357061 hasConceptScore W4387357061C41091548 @default.
• W4387357061 hasConceptScore W4387357061C54355233 @default.
• W4387357061 hasConceptScore W4387357061C67705224 @default.
• W4387357061 hasConceptScore W4387357061C86803240 @default.
• W4387357061 hasConceptScore W4387357061C95444343 @default.
• W4387357061 hasFunder F4320321001 @default.
• W4387357061 hasLocation W43873570611 @default.
• W4387357061 hasLocation W43873570612 @default.
• W4387357061 hasOpenAccess W4387357061 @default.
• W4387357061 hasPrimaryLocation W43873570611 @default.
• W4387357061 hasRelatedWork W2040362497 @default.
• W4387357061 hasRelatedWork W2051315942 @default.
• W4387357061 hasRelatedWork W2083796800 @default.
• W4387357061 hasRelatedWork W2125809142 @default.
• W4387357061 hasRelatedWork W2155211270 @default.
• W4387357061 hasRelatedWork W2343055141 @default.
• W4387357061 hasRelatedWork W2369450779 @default.
• W4387357061 hasRelatedWork W4291020423 @default.
• W4387357061 hasRelatedWork W4308958578 @default.
• W4387357061 hasRelatedWork W4309919442 @default.
• W4387357061 isParatext "false" @default.
• W4387357061 isRetracted "false" @default.

• next