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• W4387357062 abstract "Abstract In recent years, it has been shown that the liquid–liquid phase separation (LLPS) of virus proteins plays a crucial role in their life cycle. It promotes the formation of viral replication organelles, concentrating viral components for efficient replication and facilitates the assembly of viral particles. LLPS has emerged as a crucial process in the replication and assembly of herpes simplex virus‐1 (HSV‐1). Recent studies have identified several HSV‐1 proteins involved in LLPS, including the myristylated tegument protein UL11 and infected cell protein 4; however, a complete proteome‐level understanding of the LLPS‐prone HSV‐1 proteins is not available. We provide a comprehensive analysis of the HSV‐1 proteome and explore the potential of its proteins to undergo LLPS. By integrating sequence analysis, prediction algorithms and an array of tools and servers, we identified 10 HSV‐1 proteins that exhibit high LLPS potential. By analysing the amino acid sequences of the LLPS‐prone proteins, we identified specific sequence motifs and enriched amino acid residues commonly found in LLPS‐prone regions. Our findings reveal a diverse range of LLPS‐prone proteins within the HSV‐1, which are involved in critical viral processes such as replication, transcriptional regulation and assembly of viral particles. This suggests that LLPS might play a crucial role in facilitating the formation of specialized viral replication compartments and the assembly of HSV‐1 virion. The identification of LLPS‐prone proteins in HSV‐1 opens up new avenues for understanding the molecular mechanisms underlying viral pathogenesis. Our work provides valuable insights into the LLPS landscape of HSV‐1, highlighting potential targets for further experimental validation and enhancing our understanding of viral replication and pathogenesis." @default.
• W4387357062 created "2023-10-06" @default.
• W4387357062 creator A5017689461 @default.
• W4387357062 creator A5022750874 @default.
• W4387357062 creator A5024600044 @default.
• W4387357062 creator A5063182718 @default.
• W4387357062 creator A5080510069 @default.
• W4387357062 date "2023-10-05" @default.
• W4387357062 modified "2023-10-06" @default.
• W4387357062 title "Comprehensive analysis of liquid–liquid phase separation propensities of HSV‐1 proteins and their interaction with host factors" @default.
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