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• W4387357132 abstract "Colorectal cancer remains a health problem despite advances in diagnostic and treatment methods. This study aimed to determine the impact of positive-to-total lymph node ratio on survival in colorectal cancer.Patients with stage 3 colorectal cancer were included. Patients age; sex; operation type (emergency or elective); tumor size, grade, and location; TNM stage; vascular and perineural invasions; numbers of lymph nodes examined and negative lymph nodes, positive-to-total lymph node ratio, and administration of postoperative chemotherapy were examined.Median follow-up period was 34.7 months. Most patients were in stage 3b (67.9%), and the median number of dissected lymph nodes was 15. The number of metastatic lymph nodes, positive lymph node ratio, and negativeto- positive lymph node ratio were 3, 16.7, 11, and 5, respectively. The overall survival rate was 48.6%. Mean life expectancy was 51.5 months. Multivariate Cox regression analysis revealed positive-to-total lymph node ratio >23.3%, age, and absence of postoperative chemotherapy as risk factors for overall survival (p<0.05). Positive-to-total lymph node ratio >23.3% was associated with poor overall survival and 3.726-fold poorer survival.Positive-to-total lymph node ratio >23.3% is a risk factor affecting overall survival in stage 3 colorectal cancer. Increased positive-to-total lymph node ratio (>23.3%) is associated with poor overall survival.Colorectal Cancer, Overall Survival, Positive Lymph Node Ratio, Stage 3 Cancer.Il cancro del colon-retto rimane un problema di salute nonostante i progressi nei metodi diagnostici e terapeutici. Questo studio mirava a determinare l’impatto del rapporto linfonodi positivi sul totale sulla sopravvivenza nel cancro del colon-retto. Sono stati inclusi nello studio pazienti con cancro del colon-retto al III stadio, analizzando età dei pazienti, sesso, tempistica dell’intervento (di emergenza o di elezione), dimensioni, grado e posizione del tumore, stadio TNM, invasioni vascolari e perineurali. Infine sono stati esaminati il numero di linfonodi isolati, quelli negativi ed il rapporto tra linfonodi positivi e il totale, e la somministrazione o meno della chemioterapia postoperatoria. RISULTATI: Il periodo mediano di follow-up è stato di 34,7 mesi. La maggior parte dei pazienti era allo stadio 3b (67,9%) e il numero mediano di linfonodi sezionati era 15. Il numero di linfonodi metastatici, il rapporto linfonodale positivo e il rapporto linfonodale negativopositivo erano 3, 16,7, 11, e 5, rispettivamente. Il tasso di sopravvivenza globale è stato del 48,6%. L’aspettativa di vita media era di 51,5 mesi. L’analisi di regressione multivariata di Cox ha rivelato un rapporto linfonodi positivi/totali >23,3%, l’età e l’assenza di chemioterapia postoperatoria come fattori di rischio per la sopravvivenza globale (p <0,05). Il rapporto linfonodi positivi/totali >23,3% è stato associato a una sopravvivenza globale scarsa e a una sopravvivenza inferiore di 3,726 volte. DISCUSSIONE: il rapporto linfonodi positivi/totali >23,3% è un fattore di rischio che influenza la sopravvivenza globale nel cancro del colon-retto in stadio 3. L’aumento del rapporto linfonodi positivi/totali (> 23,3%) è associato a una scarsa sopravvivenza globale." @default.
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• W4387357132 date "2023-01-01" @default.
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• W4387357132 title "Impact of positive-to-total lymph node ratio on prognosis in stage 3 colorectal cancer. A multicenter study." @default.
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