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- W4387357156 abstract "Abstract Context Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) is the most prevalent chronic liver disease, affecting one-fourth of the adult population worldwide. Recent data found an association between MASLD and hypogonadism, but this relation in patients with type 2 diabetes mellitus (T2DM) is still unclear. Objective To evaluate in men with T2DM the association between total testosterone (TT) and non-invasive indices of hepatic steatosis (FLI, HSI, DSI) and fibrosis (APRI, FIB-4), and their predictive cut-off values in identifying hypogonadism. Design and setting Cross-sectional study on patients recruited on an outpatient basis. Patients 189 men with T2DM, without history of liver diseases and alcoholism. Intervention(s) Andrological evaluation, metabolic parameters, TT, and liver indices. Main Outcome Measure(s) Comparison of steatosis and fibrosis indices with testosterone levels and presence of hypogonadism. ROC curves were used to identify cut-off values of liver indices in predicting low testosterone (<12 nmol/L). Results FLI, HSI and DSI were negatively related with TT and were higher in low-testosterone group compared with normal-testosterone group (FLI: 74.1 [61.4-93.5] vs 56.5 [32.1-78.2], p < 0.001; HSI: 41.5 [39.2-45.9] vs 40.1 [36.6-43.2], p = 0.005; DSI: 0.45 [-0.08 - + 1.04] vs -0.07 [-1.02 - + 0.58], p < 0.001). FLI and DSI correlated also with clinical symptoms of hypogonadism. No differences between groups were observed for APRI and FIB-4. FLI ≥ 63 was the best parameter as predictive index of low TT (sensitivity 73%, specificity 64%). Conclusions We found an association between non-invasive indices of steatosis and hypogonadism in patients with T2DM. These indices could be used to direct the patients to andrological evaluation." @default.
- W4387357156 created "2023-10-06" @default.
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- W4387357156 date "2023-10-05" @default.
- W4387357156 modified "2023-10-06" @default.
- W4387357156 title "Non-invasive indices of MASLD are associated with hypogonadism in male patients with type 2 diabetes mellitus" @default.
- W4387357156 doi "https://doi.org/10.1210/clinem/dgad586" @default.
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