Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387357435> ?p ?o ?g. }
- W4387357435 abstract "Abstract Pathological pain, a multifaceted and debilitating ailment originating from injury or post‐injury inflammation of the somatosensory system, poses a global health challenge. Despite its ubiquity, reliable therapeutic strategies remain elusive. To solve this problem, resveratrol, a naturally occurring nonflavonoid polyphenol, has emerged as a potential beacon of hope owing to its anti‐inflammatory, antioxidant, and immunomodulatory capabilities. These properties potentially position resveratrol as an efficacious candidate for the management of pathological pain. This concise review summaries current experimental and clinical findings to underscore the therapeutic potential of resveratrol in pathological pain, casting light on the complex underlying pathophysiology. Our exploration suggests that resveratrol may exert its analgesic effect by the modulating pivotal signaling pathways, including PI3K/Akt/mTOR, TNFR1/NF‐κB, MAPKs, and Nrf2. Moreover, resveratrol appears to attenuate spinal microglia activation, regulate primary receptors in dorsal root sensory neurons, inhibit pertinent voltage‐gated ion channels, and curb the expression of inflammatory mediators and oxidative stress responses. The objective of this review is to encapsulate the pharmacological activity of resveratrol, including its probable signaling pathways, pharmacokinetics, and toxicology pertinent to the treatment of pathological pain. Hopefully, we aim to map out promising trajectories for the development of resveratrol as a potential analgesic." @default.
- W4387357435 created "2023-10-06" @default.
- W4387357435 creator A5022465946 @default.
- W4387357435 creator A5038821877 @default.
- W4387357435 creator A5060874013 @default.
- W4387357435 creator A5071460172 @default.
- W4387357435 creator A5075523709 @default.
- W4387357435 creator A5075580925 @default.
- W4387357435 creator A5089007041 @default.
- W4387357435 date "2023-10-05" @default.
- W4387357435 modified "2023-10-15" @default.
- W4387357435 title "Deciphering resveratrol's role in modulating pathological pain: From molecular mechanisms to clinical relevance" @default.
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