Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387357551> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4387357551 abstract "Skeletal muscle disuse atrophy can cause degenerative changes in neuromuscular junction morphology. Although Daurian ground squirrels ( Spermophilus dauricus) are a natural anti-disuse animal model for studying muscle atrophy during hibernation, little is known about the morphological and regulatory mechanisms of their neuromuscular junctions. Here, we found that morphological indices of the soleus muscle were significantly lower during hibernation (torpor and interbout arousal) compared to pre-hibernation but recovered during post-hibernation. In the extensor digitorum longus muscle, neuromuscular junction morphology did not change significantly during hibernation. Agrin-Lrp4-MuSK is a key pathway for the formation and maintenance of the neuromuscular junction. Our results showed that low-density lipoprotein receptor-associated protein 4 (Lrp4) expression in the soleus (slow muscle) decreased by 46.2% in the interbout arousal group compared with the pre-hibernation group ( p = 0.019), with recovery in the post-hibernation group. Compared to the pre-hibernation group, agrin expression in the extensor digitorum longus (fast muscle) increased by 67.0% in the interbout arousal group ( p = 0.016). In conclusion, periodic up-regulation in agrin expression during interbout arousal may be involved in the maintenance of neuromuscular junction morphology in the extensor digitorum longus muscle during hibernation. The degenerative changes in neuromuscular junction morphology and the periodic decrease in Lrp4 protein expression in the soleus during hibernation, these changes recovered to the pre-hibernation levels in the post-hibernation group, also exhibiting significant plasticity. This plasticity may be an important mechanism for resisting disuse atrophy in hibernating animals." @default.
- W4387357551 created "2023-10-06" @default.
- W4387357551 creator A5026949482 @default.
- W4387357551 creator A5042527675 @default.
- W4387357551 creator A5052813888 @default.
- W4387357551 creator A5057215986 @default.
- W4387357551 creator A5085295896 @default.
- W4387357551 date "2023-10-05" @default.
- W4387357551 modified "2023-10-06" @default.
- W4387357551 title "Plasticity changes in neuromuscular junction morphology and related regulatory proteins in the hibernating ground squirrel" @default.
- W4387357551 doi "https://doi.org/10.1152/japplphysiol.00334.2023" @default.
- W4387357551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37795532" @default.
- W4387357551 hasPublicationYear "2023" @default.
- W4387357551 type Work @default.
- W4387357551 citedByCount "0" @default.
- W4387357551 crossrefType "journal-article" @default.
- W4387357551 hasAuthorship W4387357551A5026949482 @default.
- W4387357551 hasAuthorship W4387357551A5042527675 @default.
- W4387357551 hasAuthorship W4387357551A5052813888 @default.
- W4387357551 hasAuthorship W4387357551A5057215986 @default.
- W4387357551 hasAuthorship W4387357551A5085295896 @default.
- W4387357551 hasConcept C100564792 @default.
- W4387357551 hasConcept C105702510 @default.
- W4387357551 hasConcept C11413529 @default.
- W4387357551 hasConcept C119865680 @default.
- W4387357551 hasConcept C126322002 @default.
- W4387357551 hasConcept C134018914 @default.
- W4387357551 hasConcept C169760540 @default.
- W4387357551 hasConcept C170493617 @default.
- W4387357551 hasConcept C2776104385 @default.
- W4387357551 hasConcept C2776263037 @default.
- W4387357551 hasConcept C2777240379 @default.
- W4387357551 hasConcept C2779024559 @default.
- W4387357551 hasConcept C2779155698 @default.
- W4387357551 hasConcept C2779959927 @default.
- W4387357551 hasConcept C2780588931 @default.
- W4387357551 hasConcept C2781172350 @default.
- W4387357551 hasConcept C41008148 @default.
- W4387357551 hasConcept C48103436 @default.
- W4387357551 hasConcept C54355233 @default.
- W4387357551 hasConcept C55493867 @default.
- W4387357551 hasConcept C66538056 @default.
- W4387357551 hasConcept C71924100 @default.
- W4387357551 hasConcept C80161118 @default.
- W4387357551 hasConcept C86803240 @default.
- W4387357551 hasConceptScore W4387357551C100564792 @default.
- W4387357551 hasConceptScore W4387357551C105702510 @default.
- W4387357551 hasConceptScore W4387357551C11413529 @default.
- W4387357551 hasConceptScore W4387357551C119865680 @default.
- W4387357551 hasConceptScore W4387357551C126322002 @default.
- W4387357551 hasConceptScore W4387357551C134018914 @default.
- W4387357551 hasConceptScore W4387357551C169760540 @default.
- W4387357551 hasConceptScore W4387357551C170493617 @default.
- W4387357551 hasConceptScore W4387357551C2776104385 @default.
- W4387357551 hasConceptScore W4387357551C2776263037 @default.
- W4387357551 hasConceptScore W4387357551C2777240379 @default.
- W4387357551 hasConceptScore W4387357551C2779024559 @default.
- W4387357551 hasConceptScore W4387357551C2779155698 @default.
- W4387357551 hasConceptScore W4387357551C2779959927 @default.
- W4387357551 hasConceptScore W4387357551C2780588931 @default.
- W4387357551 hasConceptScore W4387357551C2781172350 @default.
- W4387357551 hasConceptScore W4387357551C41008148 @default.
- W4387357551 hasConceptScore W4387357551C48103436 @default.
- W4387357551 hasConceptScore W4387357551C54355233 @default.
- W4387357551 hasConceptScore W4387357551C55493867 @default.
- W4387357551 hasConceptScore W4387357551C66538056 @default.
- W4387357551 hasConceptScore W4387357551C71924100 @default.
- W4387357551 hasConceptScore W4387357551C80161118 @default.
- W4387357551 hasConceptScore W4387357551C86803240 @default.
- W4387357551 hasFunder F4320321001 @default.
- W4387357551 hasFunder F4320324173 @default.
- W4387357551 hasLocation W43873575511 @default.
- W4387357551 hasLocation W43873575512 @default.
- W4387357551 hasOpenAccess W4387357551 @default.
- W4387357551 hasPrimaryLocation W43873575511 @default.
- W4387357551 hasRelatedWork W2055346971 @default.
- W4387357551 hasRelatedWork W2079831849 @default.
- W4387357551 hasRelatedWork W2083420536 @default.
- W4387357551 hasRelatedWork W2136591670 @default.
- W4387357551 hasRelatedWork W2369641421 @default.
- W4387357551 hasRelatedWork W2416825416 @default.
- W4387357551 hasRelatedWork W2473315147 @default.
- W4387357551 hasRelatedWork W3195984521 @default.
- W4387357551 hasRelatedWork W4376866198 @default.
- W4387357551 hasRelatedWork W61013187 @default.
- W4387357551 isParatext "false" @default.
- W4387357551 isRetracted "false" @default.
- W4387357551 workType "article" @default.