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- W4387357557 abstract "Abstract Novel CRISPR systems capable of cleaving both DNA and RNA are progressively emerging as attractive tools for genome manipulation of prokaryotic and eukaryotic organisms. We report specific characteristics of CRISPR systems present in Oxynema aestuarii AP17, a halotolerant, filamentous cyanobacterium and the second known member of the Oxynema genus. In‐silico analyses of its whole‐genome sequence revealed the presence of multiple Type I and Type III CRISPR loci with one Type I‐G system previously unreported in cyanobacteria. We further identified the leader sequences at the 5′ end of multiple CRISPR loci, many of which were distinct from previously reported cyanobacterial CRISPR leaders. Phylogenetic analyses of the O. aestuarii AP17 Cas1 proteins revealed two protein sequences that were unique and distantly related to other cyanobacterial Cas1 protein sequences. Our findings are significant because novel Class 1 CRISPR systems possess multi‐subunit effectors and are highly flexible for repurposing by protein domain fusions made to the effector complex. Additionally, Type III CRISPRs are particularly useful for genome editing in certain extremophiles for which mesophilic Type II CRISPRs are ineffective." @default.
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- W4387357557 date "2023-10-05" @default.
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- W4387357557 title "In‐silico whole‐genome sequence analysis of a halotolerant filamentous mangrove cyanobacterium revealed CRISPR‐Cas systems with unique properties" @default.
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- W4387357557 doi "https://doi.org/10.1111/jpy.13393" @default.
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