Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387357589> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4387357589 abstract "Introduction: Interventions targeting cholinergic neurotransmission like acetylcholinesterase (AChE) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. However, the chronic effects of these interventions are not well-described. Methods: In the current study, global levels of cholinergic, cellular, synaptic, and inflammation-mediating proteins were assessed within the context of aging and chronic reduction of AChE activity. Long-term depletion of AChE activity was induced by using a mutant zebrafish line and they were compared with the wildtype group at young and old ages. Results: Results demonstrated that AChE activity was lower in both young and old mutants and this decrease coincided with a reduction in ACh content. Additionally, an overall age-related reduction in AChE activity and the AChE/ACh ratio was observed, this decline was more prominent in wildtype groups. The levels of an immature neuronal marker were upregulated in mutants, while a glial marker showed an overall reduction. Mutants had preserved levels of inhibitory and presynaptic elements with aging, whereas glutamate receptor subunit levels declined. Discussion/Conclusion: Long-term AChE activity depletion induces synaptic and cellular alterations. These data provide further insights into molecular targets and adaptive responses following the long-term reduction of AChE activity that was also targeted pharmacologically to treat neurodegenerative diseases in human subjects." @default.
- W4387357589 created "2023-10-06" @default.
- W4387357589 creator A5030197969 @default.
- W4387357589 creator A5031937196 @default.
- W4387357589 creator A5034960620 @default.
- W4387357589 creator A5042374275 @default.
- W4387357589 creator A5059379437 @default.
- W4387357589 creator A5064104783 @default.
- W4387357589 creator A5076123561 @default.
- W4387357589 creator A5084851102 @default.
- W4387357589 date "2023-10-04" @default.
- W4387357589 modified "2023-10-12" @default.
- W4387357589 title "Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain" @default.
- W4387357589 doi "https://doi.org/10.1159/000534343" @default.
- W4387357589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37793352" @default.
- W4387357589 hasPublicationYear "2023" @default.
- W4387357589 type Work @default.
- W4387357589 citedByCount "0" @default.
- W4387357589 crossrefType "journal-article" @default.
- W4387357589 hasAuthorship W4387357589A5030197969 @default.
- W4387357589 hasAuthorship W4387357589A5031937196 @default.
- W4387357589 hasAuthorship W4387357589A5034960620 @default.
- W4387357589 hasAuthorship W4387357589A5042374275 @default.
- W4387357589 hasAuthorship W4387357589A5059379437 @default.
- W4387357589 hasAuthorship W4387357589A5064104783 @default.
- W4387357589 hasAuthorship W4387357589A5076123561 @default.
- W4387357589 hasAuthorship W4387357589A5084851102 @default.
- W4387357589 hasBestOaLocation W43873575891 @default.
- W4387357589 hasConcept C104317684 @default.
- W4387357589 hasConcept C126322002 @default.
- W4387357589 hasConcept C134018914 @default.
- W4387357589 hasConcept C151730666 @default.
- W4387357589 hasConcept C169760540 @default.
- W4387357589 hasConcept C170493617 @default.
- W4387357589 hasConcept C181199279 @default.
- W4387357589 hasConcept C200170125 @default.
- W4387357589 hasConcept C22885893 @default.
- W4387357589 hasConcept C2776219046 @default.
- W4387357589 hasConcept C2776878037 @default.
- W4387357589 hasConcept C2778816929 @default.
- W4387357589 hasConcept C2779059548 @default.
- W4387357589 hasConcept C2779343474 @default.
- W4387357589 hasConcept C529278444 @default.
- W4387357589 hasConcept C55493867 @default.
- W4387357589 hasConcept C71924100 @default.
- W4387357589 hasConcept C86803240 @default.
- W4387357589 hasConceptScore W4387357589C104317684 @default.
- W4387357589 hasConceptScore W4387357589C126322002 @default.
- W4387357589 hasConceptScore W4387357589C134018914 @default.
- W4387357589 hasConceptScore W4387357589C151730666 @default.
- W4387357589 hasConceptScore W4387357589C169760540 @default.
- W4387357589 hasConceptScore W4387357589C170493617 @default.
- W4387357589 hasConceptScore W4387357589C181199279 @default.
- W4387357589 hasConceptScore W4387357589C200170125 @default.
- W4387357589 hasConceptScore W4387357589C22885893 @default.
- W4387357589 hasConceptScore W4387357589C2776219046 @default.
- W4387357589 hasConceptScore W4387357589C2776878037 @default.
- W4387357589 hasConceptScore W4387357589C2778816929 @default.
- W4387357589 hasConceptScore W4387357589C2779059548 @default.
- W4387357589 hasConceptScore W4387357589C2779343474 @default.
- W4387357589 hasConceptScore W4387357589C529278444 @default.
- W4387357589 hasConceptScore W4387357589C55493867 @default.
- W4387357589 hasConceptScore W4387357589C71924100 @default.
- W4387357589 hasConceptScore W4387357589C86803240 @default.
- W4387357589 hasLocation W43873575891 @default.
- W4387357589 hasLocation W43873575892 @default.
- W4387357589 hasOpenAccess W4387357589 @default.
- W4387357589 hasPrimaryLocation W43873575891 @default.
- W4387357589 hasRelatedWork W2044462923 @default.
- W4387357589 hasRelatedWork W2088749540 @default.
- W4387357589 hasRelatedWork W2362666580 @default.
- W4387357589 hasRelatedWork W2379581464 @default.
- W4387357589 hasRelatedWork W2391822070 @default.
- W4387357589 hasRelatedWork W2419227657 @default.
- W4387357589 hasRelatedWork W2425102144 @default.
- W4387357589 hasRelatedWork W2547206251 @default.
- W4387357589 hasRelatedWork W2553900499 @default.
- W4387357589 hasRelatedWork W2929872936 @default.
- W4387357589 isParatext "false" @default.
- W4387357589 isRetracted "false" @default.
- W4387357589 workType "article" @default.