FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387357679> ?p ?o ?g. }

• W4387357679 abstract "ABSTRACT Myxovirus resistance proteins A and B (MxA and MxB) are interferon-induced proteins that exert antiviral activity against a diverse range of RNA and DNA viruses. In primates, MxA has been shown to inhibit myxoviruses, bunyaviruses, and the hepatitis B virus, whereas MxB restricts retroviruses and herpesviruses. As a result of their conflicts with viruses, both genes have been undergoing diversifying selection during primate evolution. Here, we investigate how MxB evolution in primates has affected its restriction of herpesviruses. In contrast to human MxB, we find that most primate orthologs, including the closely related chimpanzee MxB, do not inhibit herpes simplex virus (HSV-1) replication. However, all primate MxB orthologs tested restricted human cytomegalovirus. Through the generation of human and chimpanzee MxB chimeras, we show that a single residue, M83, is the key determinant of restriction of HSV-1 replication. Humans are the only primate species known to encode a methionine at this position, whereas most other primate species encode a lysine. Residue 83 is also the most polymorphic residue in MxB in human populations, with M83 being the most common variant. However, ~2.5% of human MxB alleles encode a threonine at this position, which does not restrict HSV-1. Thus, a single amino acid variant in MxB, which has recently risen to high frequency in humans, has endowed human MxB with HSV-1 antiviral activity. IMPORTANCE Herpesviruses present a major global disease burden. Understanding the host cell mechanisms that block viral infections, as well as how viruses can evolve to counteract these host defenses, is critically important for understanding viral disease pathogenesis. This study reveals that the major human variant of the antiviral protein myxovirus resistance protein B (MxB) inhibits the human pathogen herpes simplex virus (HSV-1), whereas a minor human variant and orthologous MxB genes from even closely related primates do not. Thus, in contrast to the many antagonistic virus-host interactions in which the virus is successful in thwarting the host’s defense systems, here the human gene appears to be at least temporarily winning at this interface of the primate-herpesvirus evolutionary arms race. Our findings further show that a polymorphism at amino acid 83 in a small fraction of the human population is sufficient to abrogate MxB’s ability to inhibit HSV-1, which could have important implications for human susceptibility to HSV-1 pathogenesis." @default.
• W4387357679 created "2023-10-06" @default.
• W4387357679 creator A5038631849 @default.
• W4387357679 creator A5062853660 @default.
• W4387357679 creator A5081607195 @default.
• W4387357679 creator A5063097195 @default.
• W4387357679 date "2023-10-05" @default.
• W4387357679 modified "2023-10-06" @default.
• W4387357679 title "A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB" @default.
• W4387357679 cites W1956441144 @default.
• W4387357679 cites W1979249841 @default.
• W4387357679 cites W2022053679 @default.
• W4387357679 cites W2034116174 @default.
• W4387357679 cites W2039325208 @default.
• W4387357679 cites W2049636398 @default.
• W4387357679 cites W2062346435 @default.
• W4387357679 cites W2070563411 @default.
• W4387357679 cites W2079671323 @default.
• W4387357679 cites W2103208990 @default.
• W4387357679 cites W2106872247 @default.
• W4387357679 cites W2114794895 @default.
• W4387357679 cites W2115036202 @default.
• W4387357679 cites W2117698920 @default.
• W4387357679 cites W2125957866 @default.
• W4387357679 cites W2132192295 @default.
• W4387357679 cites W2191476384 @default.
• W4387357679 cites W2537689739 @default.
• W4387357679 cites W2803453391 @default.
• W4387357679 cites W2810169082 @default.
• W4387357679 cites W2884584240 @default.
• W4387357679 cites W2885885677 @default.
• W4387357679 cites W2949242965 @default.
• W4387357679 cites W2952387665 @default.
• W4387357679 cites W2959449984 @default.
• W4387357679 cites W3029661147 @default.
• W4387357679 cites W3032034316 @default.
• W4387357679 cites W4226022631 @default.
• W4387357679 cites W4378515956 @default.
• W4387357679 cites W4381890299 @default.
• W4387357679 doi "https://doi.org/10.1128/jvi.00830-23" @default.
• W4387357679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37796130" @default.
• W4387357679 hasPublicationYear "2023" @default.
• W4387357679 type Work @default.
• W4387357679 citedByCount "0" @default.
• W4387357679 crossrefType "journal-article" @default.
• W4387357679 hasAuthorship W4387357679A5038631849 @default.
• W4387357679 hasAuthorship W4387357679A5062853660 @default.
• W4387357679 hasAuthorship W4387357679A5063097195 @default.
• W4387357679 hasAuthorship W4387357679A5081607195 @default.
• W4387357679 hasConcept C104317684 @default.
• W4387357679 hasConcept C140704245 @default.
• W4387357679 hasConcept C141231307 @default.
• W4387357679 hasConcept C159047783 @default.
• W4387357679 hasConcept C2522874641 @default.
• W4387357679 hasConcept C2776746152 @default.
• W4387357679 hasConcept C2779820661 @default.
• W4387357679 hasConcept C2781196997 @default.
• W4387357679 hasConcept C54355233 @default.
• W4387357679 hasConcept C67705224 @default.
• W4387357679 hasConcept C86803240 @default.
• W4387357679 hasConcept C8769409 @default.
• W4387357679 hasConceptScore W4387357679C104317684 @default.
• W4387357679 hasConceptScore W4387357679C140704245 @default.
• W4387357679 hasConceptScore W4387357679C141231307 @default.
• W4387357679 hasConceptScore W4387357679C159047783 @default.
• W4387357679 hasConceptScore W4387357679C2522874641 @default.
• W4387357679 hasConceptScore W4387357679C2776746152 @default.
• W4387357679 hasConceptScore W4387357679C2779820661 @default.
• W4387357679 hasConceptScore W4387357679C2781196997 @default.
• W4387357679 hasConceptScore W4387357679C54355233 @default.
• W4387357679 hasConceptScore W4387357679C67705224 @default.
• W4387357679 hasConceptScore W4387357679C86803240 @default.
• W4387357679 hasConceptScore W4387357679C8769409 @default.
• W4387357679 hasFunder F4320306082 @default.
• W4387357679 hasFunder F4320337355 @default.
• W4387357679 hasLocation W43873576791 @default.
• W4387357679 hasLocation W43873576792 @default.
• W4387357679 hasOpenAccess W4387357679 @default.
• W4387357679 hasPrimaryLocation W43873576791 @default.
• W4387357679 hasRelatedWork W17971944 @default.
• W4387357679 hasRelatedWork W1877301543 @default.
• W4387357679 hasRelatedWork W2132491919 @default.
• W4387357679 hasRelatedWork W2145449008 @default.
• W4387357679 hasRelatedWork W2150241121 @default.
• W4387357679 hasRelatedWork W2153889832 @default.
• W4387357679 hasRelatedWork W2154028161 @default.
• W4387357679 hasRelatedWork W2168094636 @default.
• W4387357679 hasRelatedWork W2231521459 @default.
• W4387357679 hasRelatedWork W3127741989 @default.
• W4387357679 isParatext "false" @default.
• W4387357679 isRetracted "false" @default.
• W4387357679 workType "article" @default.