FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387357911> ?p ?o ?g. }

• W4387357911 abstract "Background: Commonly encountered nontraumatic, moderate noise is increasingly implicated in anxiety; however, the neural substrates underlying this process remain unclear. Objectives: We investigated the neural circuit mechanism through which chronic exposure to moderate-level noise causes anxiety-like behaviors. Methods: Mice were exposed to chronic, moderate white noise [85 decibel (dB) sound pressure level (SPL)], 4 h/d for 4 wk to induce anxiety-like behaviors, which were assessed by open field, elevated plus maze, light-dark box, and social interaction tests. Viral tracing, immunofluorescence confocal imaging, and brain slice patch-clamp recordings were used to characterize projections from auditory brain regions to the lateral amygdala. Neuronal activities were characterized by in vivo multielectrode and fiber photometry recordings in awake mice. Optogenetics and chemogenetics were used to manipulate specific neural circuitry. Results: Mice chronically (4 wk) exposed to moderate noise (85 dB SPL, 4 h/d) demonstrated greater neuronal activity in the lateral amygdala (LA), and the LA played a critical role in noise-induced anxiety-like behavior in these model mice. Viral tracing showed that the LA received monosynaptic projections from the medial geniculate body (MG) and auditory cortex (ACx). Optogenetic excitation of the MG→LA or ACx→LA circuits acutely evoked anxiety-like behaviors, whereas their chemogenetic inactivation abolished noise-induced anxiety-like behavior. Moreover, mice chronically exposed to moderate noise were more susceptible to acute stress, with more neuronal firing in the LA, even after noise withdrawal. Discussion: Mice exposed to 4 wk of moderate noise (85 dB SPL, 4 h/d) demonstrated behavioral and physiological differences compared to controls. The neural circuit mechanisms involved greater excitation from glutamatergic neurons of the MG and ACx to LA neurons under chronic, moderate noise exposure, which ultimately promoted anxiety-like behaviors. Our findings support the hypothesis that nontraumatic noise pollution is a potentially serious but unrecognized public health concern. https://doi.org/10.1289/EHP12532" @default.
• W4387357911 created "2023-10-06" @default.
• W4387357911 creator A5002881873 @default.
• W4387357911 creator A5002884286 @default.
• W4387357911 creator A5012780299 @default.
• W4387357911 creator A5013165704 @default.
• W4387357911 creator A5023598186 @default.
• W4387357911 creator A5047958678 @default.
• W4387357911 creator A5055964434 @default.
• W4387357911 creator A5071433603 @default.
• W4387357911 creator A5076015367 @default.
• W4387357911 creator A5076112933 @default.
• W4387357911 creator A5078155730 @default.
• W4387357911 creator A5078739680 @default.
• W4387357911 creator A5080102032 @default.
• W4387357911 creator A5087404367 @default.
• W4387357911 date "2023-10-01" @default.
• W4387357911 modified "2023-10-06" @default.
• W4387357911 title "Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice" @default.
• W4387357911 cites W1007538204 @default.
• W4387357911 cites W1547865271 @default.
• W4387357911 cites W1582850395 @default.
• W4387357911 cites W1582867246 @default.
• W4387357911 cites W1695265315 @default.
• W4387357911 cites W1903965668 @default.
• W4387357911 cites W1909104250 @default.
• W4387357911 cites W1963723820 @default.
• W4387357911 cites W1964160578 @default.
• W4387357911 cites W1966475994 @default.
• W4387357911 cites W1982864908 @default.
• W4387357911 cites W1985380021 @default.
• W4387357911 cites W1989982790 @default.
• W4387357911 cites W1997982013 @default.
• W4387357911 cites W2005494821 @default.
• W4387357911 cites W2007674059 @default.
• W4387357911 cites W2022842010 @default.
• W4387357911 cites W2038352546 @default.
• W4387357911 cites W2053486952 @default.
• W4387357911 cites W2053967275 @default.
• W4387357911 cites W2054950553 @default.
• W4387357911 cites W2058485216 @default.
• W4387357911 cites W2060978874 @default.
• W4387357911 cites W2061581416 @default.
• W4387357911 cites W2062573109 @default.
• W4387357911 cites W2072698768 @default.
• W4387357911 cites W2084070063 @default.
• W4387357911 cites W2085393729 @default.
• W4387357911 cites W2087484885 @default.
• W4387357911 cites W2090654839 @default.
• W4387357911 cites W2104419150 @default.
• W4387357911 cites W2111114823 @default.
• W4387357911 cites W2114214919 @default.
• W4387357911 cites W2123717940 @default.
• W4387357911 cites W2152983690 @default.
• W4387357911 cites W2161838364 @default.
• W4387357911 cites W2161902396 @default.
• W4387357911 cites W2210264310 @default.
• W4387357911 cites W2224362692 @default.
• W4387357911 cites W2258511068 @default.
• W4387357911 cites W2342900568 @default.
• W4387357911 cites W2346408463 @default.
• W4387357911 cites W2514163892 @default.
• W4387357911 cites W2543882133 @default.
• W4387357911 cites W2570038129 @default.
• W4387357911 cites W2735226055 @default.
• W4387357911 cites W2755880500 @default.
• W4387357911 cites W2757219164 @default.
• W4387357911 cites W2793634050 @default.
• W4387357911 cites W2795205220 @default.
• W4387357911 cites W2809036469 @default.
• W4387357911 cites W2809127063 @default.
• W4387357911 cites W2885517191 @default.
• W4387357911 cites W2904244708 @default.
• W4387357911 cites W2911101888 @default.
• W4387357911 cites W2940641162 @default.
• W4387357911 cites W2944618160 @default.
• W4387357911 cites W2950278201 @default.
• W4387357911 cites W2970589643 @default.
• W4387357911 cites W2985086079 @default.
• W4387357911 cites W2991472450 @default.
• W4387357911 cites W3000708535 @default.
• W4387357911 cites W3013420451 @default.
• W4387357911 cites W3024313607 @default.
• W4387357911 cites W3035944317 @default.
• W4387357911 cites W3047998853 @default.
• W4387357911 cites W3096345730 @default.
• W4387357911 cites W3108653305 @default.
• W4387357911 cites W3118842600 @default.
• W4387357911 cites W3176396850 @default.
• W4387357911 cites W3189497181 @default.
• W4387357911 cites W3195834483 @default.
• W4387357911 cites W4220983882 @default.
• W4387357911 cites W4225530322 @default.
• W4387357911 cites W4226464093 @default.
• W4387357911 cites W4229057655 @default.
• W4387357911 cites W4229460459 @default.
• W4387357911 cites W4283267400 @default.
• W4387357911 cites W4284667933 @default.
• W4387357911 cites W4311315635 @default.
• W4387357911 cites W943827575 @default.

• next