FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387360623> ?p ?o ?g. }

• W4387360623 abstract "Abstract Disclosure: N. Saadat: None. J.N. Ciarelli: None. B. Pallas: None. V. Padmanabhan: None. A.K. Vyas: None. Gestational hyperandrogenism such as that seen in Polycystic Ovary Syndrome (PCOS), leads to adverse offspring health outcomes in both humans and animals. Prenatal T excess (T) in a sheep model of PCOS phenotype induces peripheral insulin resistance, dyslipidemia, adipocyte defects, liver steatosis, pathological cardiac remodeling and hypertension in the female offspring. Whether these adverse cardiometabolic outcomes evidenced in the female offspring also extends to male offspring needs to be addressed. We hypothesized that prenatal T excess will induce sex-specific disruptions in lipid metabolism of newborn lambs thereby contributing to the aberrant cardiometabolic phenotype. Shotgun Lipidomics was performed on the plasma samples collected at 48 hours after birth from prenatal T treated (100mg T-propionate in corn oil from days 30 to 90 of gestation intramuscularly; Term: 147days) and control (C, vehicle only) lambs (N=26, Female C=4, T=7 and Male C=5, T=10). The data was analyzed by multivariate dimensionality reduction modeling followed by functional enrichment and pathway analyses. Unsupervised 3D principal component analysis and supervised models showed separation between C and T groupings in female and male lambs. Most lipids responsible for this separation were from glycerophospholipids and glycerolipids classes in both sexes. Prenatal T excess led to an increase in cholesterol levels only in female lambs as opposed to a decrease in levels of carnitine species (CAR) CAR 16:1 and CAR 14:1 and phosphatidylcholine species (PC) PC 39:4, PC 39:5 and PC 38:5 in male lambs. To investigate the impact of prenatal T excess on lipid metabolism pathways and active reactions, 738 lipid species were mapped, of which 147 were found to be active in reactions. The active reactions involving conversion of ether linked diglycerides (DG) to ether linked phosphatidylethanolamines (PE, O-DG→O-PE, z-score 3.367, p &lt;0.05) and ether linked PC (O-DG →O-PC, z-score 2.299, p &lt; 0.05) were increased in female lambs. In contrast, the conversion of PE to PC to phosphatidic acids (PA) was suppressed (PE→PC→PA, z-score 2.133, p &lt;0.05) in prenatal T-treated male lambs pointing towards the suppression of Phosphatidylethanolamine N-methyltransferase (PEMT) phosphatidylcholine synthesis pathway. Higher cholesterol levels in T female lambs could contribute toward the adverse cardiometabolic phenotype evidenced earlier in this model, whereas suppressed PEMT pathway could lead to endoplasmic reticulum stress, defects in membrane permeability and lipid transport that may lead to liver steatosis in T male lambs. These novel findings of sex-specific effects of gestational exposure to T excess on lipid metabolism of newborn lamb, a precocial model of translational relevance, may have sex-specific functional outcomes in cardiometabolic systems. Presentation: Friday, June 16, 2023" @default.
• W4387360623 created "2023-10-06" @default.
• W4387360623 creator A5002408641 @default.
• W4387360623 creator A5003436454 @default.
• W4387360623 creator A5029119143 @default.
• W4387360623 creator A5053803753 @default.
• W4387360623 creator A5065842402 @default.
• W4387360623 date "2023-10-01" @default.
• W4387360623 modified "2023-10-06" @default.
• W4387360623 title "FRI103 Developmental Programming: Sex-specific Differences In Lipid Metabolism Of Newborn Lambs Exposed To Prenatal Testosterone Excess" @default.
• W4387360623 doi "https://doi.org/10.1210/jendso/bvad114.617" @default.
• W4387360623 hasPublicationYear "2023" @default.
• W4387360623 type Work @default.
• W4387360623 citedByCount "0" @default.
• W4387360623 crossrefType "journal-article" @default.
• W4387360623 hasAuthorship W4387360623A5002408641 @default.
• W4387360623 hasAuthorship W4387360623A5003436454 @default.
• W4387360623 hasAuthorship W4387360623A5029119143 @default.
• W4387360623 hasAuthorship W4387360623A5053803753 @default.
• W4387360623 hasAuthorship W4387360623A5065842402 @default.
• W4387360623 hasBestOaLocation W43873606231 @default.
• W4387360623 hasConcept C112672928 @default.
• W4387360623 hasConcept C126322002 @default.
• W4387360623 hasConcept C134018914 @default.
• W4387360623 hasConcept C2777391703 @default.
• W4387360623 hasConcept C2778096610 @default.
• W4387360623 hasConcept C2779234561 @default.
• W4387360623 hasConcept C3018442814 @default.
• W4387360623 hasConcept C511355011 @default.
• W4387360623 hasConcept C54355233 @default.
• W4387360623 hasConcept C58017582 @default.
• W4387360623 hasConcept C60644358 @default.
• W4387360623 hasConcept C71924100 @default.
• W4387360623 hasConcept C86803240 @default.
• W4387360623 hasConceptScore W4387360623C112672928 @default.
• W4387360623 hasConceptScore W4387360623C126322002 @default.
• W4387360623 hasConceptScore W4387360623C134018914 @default.
• W4387360623 hasConceptScore W4387360623C2777391703 @default.
• W4387360623 hasConceptScore W4387360623C2778096610 @default.
• W4387360623 hasConceptScore W4387360623C2779234561 @default.
• W4387360623 hasConceptScore W4387360623C3018442814 @default.
• W4387360623 hasConceptScore W4387360623C511355011 @default.
• W4387360623 hasConceptScore W4387360623C54355233 @default.
• W4387360623 hasConceptScore W4387360623C58017582 @default.
• W4387360623 hasConceptScore W4387360623C60644358 @default.
• W4387360623 hasConceptScore W4387360623C71924100 @default.
• W4387360623 hasConceptScore W4387360623C86803240 @default.
• W4387360623 hasIssue "Supplement_1" @default.
• W4387360623 hasLocation W43873606231 @default.
• W4387360623 hasOpenAccess W4387360623 @default.
• W4387360623 hasPrimaryLocation W43873606231 @default.
• W4387360623 hasRelatedWork W1980117820 @default.
• W4387360623 hasRelatedWork W1996322489 @default.
• W4387360623 hasRelatedWork W2016258313 @default.
• W4387360623 hasRelatedWork W2017497567 @default.
• W4387360623 hasRelatedWork W2039412011 @default.
• W4387360623 hasRelatedWork W2105558110 @default.
• W4387360623 hasRelatedWork W2133577258 @default.
• W4387360623 hasRelatedWork W2393378262 @default.
• W4387360623 hasRelatedWork W2496469184 @default.
• W4387360623 hasRelatedWork W4237091814 @default.
• W4387360623 hasVolume "7" @default.
• W4387360623 isParatext "false" @default.
• W4387360623 isRetracted "false" @default.
• W4387360623 workType "article" @default.