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- W4387360650 abstract "Abstract Hypoxic–ischemic brain damage (HIBD) in the perinatal period is an important cause of cerebral damage and long-term neurological sequelae, and can place much pressure on families and society. Our previous study demonstrated that miRNA-326 reduces neuronal apoptosis by up-regulating the δ-opioid receptor (DOR) under oxygen–glucose deprivation in vitro. In the present study, we aimed to explore the neuroprotective effects of the miRNA-326/DOR axis by inhibiting apoptosis in HIBD using neonatal miRNA-326 knockout mice. Neonatal C57BL/6 mice, neonatal miRNA-326 knockout mice, and neonatal miRNA-326 knockout mice intraperitoneally injected with the DOR inhibitor naltrindole were treated with hypoxic ischemia (HI). Neurological deficit scores, magnetic resonance imaging, terminal deoxynucleotidyl transferase-mediated uridine 5′-triphosphate-biotin nick end labeling, and caspase-3, Bax, and B-cell lymphoma 2 (Bcl-2) expression were evaluated on day 2 after HI. Neurobehavioral analyses, including the righting reflex test, suspension experiment, and cliff escape test, were performed on days 2 and 28 after HI. Additionally, the Morris water maze test was conducted on day 28. Compared with HI-treated neonatal C57BL/6 mice, HI-treated neonatal miRNA-326 knockout mice had higher neurological deficit scores, smaller cerebral infarction areas, and improved motor function, reaction ability, and long-term spatial learning and memory. These effects were likely the result of inhibiting apoptosis; the DOR inhibitor reversed these neuroprotective effects. Our findings indicate that miRNA-326 knockout plays a neuroprotective effect in neonatal HIBD by inhibiting apoptosis via the target gene DOR." @default.
- W4387360650 created "2023-10-06" @default.
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- W4387360650 date "2023-10-05" @default.
- W4387360650 modified "2023-10-06" @default.
- W4387360650 title "Neuroprotective effects of miRNA-326 knockout in neonatal hypoxic–ischemic brain damage mice via the δ–opioid receptor" @default.
- W4387360650 doi "https://doi.org/10.21203/rs.3.rs-3381727/v1" @default.
- W4387360650 hasPublicationYear "2023" @default.
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