FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387360881> ?p ?o ?g. }

• W4387360881 abstract "Abstract Disclosure: M.M. Nunez Stosic: None. T. Seeherunvong: None. Although hypothyroidism typically delays puberty, early pubertal development in patients with hypothyroidism and markedly elevated TSH levels has been reported. Recent studies investigated the association between thyroid function and timing of puberty among normal children. Jung et al. reported an association between serum TSH and LH levels in girls with central precocious puberty. By contrast Wilken et al. found an association between serum T4 level and onset of pubarche but not thelarche among female subjects. We investigated the association between serum TSH levels and onset of secondary sexual characteristics among patients with congenital hypothyroidism. A retrospective study was conducted including girls and boys aged ≥6 years and ≤ 18 years with confirmed primary congenital hypothyroidism who were seen in our pediatric endocrinology clinic at University of Miami, between May 2012 and May 2022. Age of onset of secondary sexual characteristics (SSC) such as body odor, acne, axillary hair, pubic hair, breast/testicular development was recorded. Early onset of SSC was defined by its presence in girls younger than 8 years and in boys younger than 9 years. Onset of SSC was considered early normal if it occurred between 8-9.5 years in girls and between 9-10.5 years in boys. A third group of patients were those with onset of SSC after 9.5 years in girls and after 10.5 years in boys. We recorded the serum TSH levels from age 6-8 years in girls and from 7-9 years in boys. We determined the average TSH levels and the proportion of the serum TSH level above normal range. IBM SPSS Statistics software version 28.0.0.0(190) was used for data analysis. Fifty-seven subjects with a history of congenital hypothyroidism, 36 girls (63.2%) and 21 boys (36.8%) were included in the study. Seventeen patients (29.8%) had early or early normal onset of SSC. The prevalence was more frequent among girls than boys, 14% and 3% respectively (p value= 0.046). Among all 57 subjects, only 9 had normal serum TSH. The mean proportion of TSH levels above normal limit was 62.4% in patients with early or normal early onset of SSC. By contrast, the mean proportion of serum TSH level above normal limit was 53.7% in those patients who had neither early nor early normal onset of SSC (p value=0.044). In summary, early and early normal onset of SSC was associated with higher TSH levels in children with congenital hypothyroidism. Further studies with a larger number of subjects will be needed to define further the specific SSC most associated with an abnormally elevated TSH. Presentation: Friday, June 16, 2023" @default.
• W4387360881 created "2023-10-06" @default.
• W4387360881 creator A5000713924 @default.
• W4387360881 creator A5089047202 @default.
• W4387360881 date "2023-10-01" @default.
• W4387360881 modified "2023-10-06" @default.
• W4387360881 title "FRI490 Association Between TSH Levels And Early Development Of Secondary Sexual Characteristics Among Children With Congenital Hypothyroidism" @default.
• W4387360881 doi "https://doi.org/10.1210/jendso/bvad114.1836" @default.
• W4387360881 hasPublicationYear "2023" @default.
• W4387360881 type Work @default.
• W4387360881 citedByCount "0" @default.
• W4387360881 crossrefType "journal-article" @default.
• W4387360881 hasAuthorship W4387360881A5000713924 @default.
• W4387360881 hasAuthorship W4387360881A5089047202 @default.
• W4387360881 hasBestOaLocation W43873608811 @default.
• W4387360881 hasConcept C126322002 @default.
• W4387360881 hasConcept C134018914 @default.
• W4387360881 hasConcept C187212893 @default.
• W4387360881 hasConcept C2776880931 @default.
• W4387360881 hasConcept C2777252872 @default.
• W4387360881 hasConcept C2778367240 @default.
• W4387360881 hasConcept C2779258352 @default.
• W4387360881 hasConcept C526584372 @default.
• W4387360881 hasConcept C71315377 @default.
• W4387360881 hasConcept C71924100 @default.
• W4387360881 hasConcept C77018033 @default.
• W4387360881 hasConceptScore W4387360881C126322002 @default.
• W4387360881 hasConceptScore W4387360881C134018914 @default.
• W4387360881 hasConceptScore W4387360881C187212893 @default.
• W4387360881 hasConceptScore W4387360881C2776880931 @default.
• W4387360881 hasConceptScore W4387360881C2777252872 @default.
• W4387360881 hasConceptScore W4387360881C2778367240 @default.
• W4387360881 hasConceptScore W4387360881C2779258352 @default.
• W4387360881 hasConceptScore W4387360881C526584372 @default.
• W4387360881 hasConceptScore W4387360881C71315377 @default.
• W4387360881 hasConceptScore W4387360881C71924100 @default.
• W4387360881 hasConceptScore W4387360881C77018033 @default.
• W4387360881 hasIssue "Supplement_1" @default.
• W4387360881 hasLocation W43873608811 @default.
• W4387360881 hasOpenAccess W4387360881 @default.
• W4387360881 hasPrimaryLocation W43873608811 @default.
• W4387360881 hasRelatedWork W1914217892 @default.
• W4387360881 hasRelatedWork W2536535474 @default.
• W4387360881 hasRelatedWork W2563136572 @default.
• W4387360881 hasRelatedWork W2780174113 @default.
• W4387360881 hasRelatedWork W2902465641 @default.
• W4387360881 hasRelatedWork W3083071277 @default.
• W4387360881 hasRelatedWork W3209102422 @default.
• W4387360881 hasRelatedWork W33294841 @default.
• W4387360881 hasRelatedWork W4310366035 @default.
• W4387360881 hasRelatedWork W1534701322 @default.
• W4387360881 hasVolume "7" @default.
• W4387360881 isParatext "false" @default.
• W4387360881 isRetracted "false" @default.
• W4387360881 workType "article" @default.